يعرض 81 - 100 نتائج من 64,878 نتيجة بحث عن '(( 5 ((nn decrease) OR (a decrease)) ) OR ((( 50 mg decrease ) OR ( 5 nm decrease ))))', وقت الاستعلام: 0.92s تنقيح النتائج
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    Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... حسب Shuai Wang (109515)

    منشور في 2021
    "…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC<sub>50</sub> = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …"
  6. 86

    Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... حسب Shuai Wang (109515)

    منشور في 2021
    "…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC<sub>50</sub> = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …"
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    Oxytocin decreases postsynaptic CeA spontaneous GABAergic transmission and blocks presynaptic alcohol effects. حسب Brendan J. Tunstall (6593357)

    منشور في 2019
    "…<p>(A, Top) Representative GABA<sub>A</sub>-mediated sIPSCs of CeA neurons from nondependent and dependent rats prior to (baseline) and during application of oxytocin (500 nM). …"
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    The decrease or inhibition of Hsp90 induced REST degradation. حسب Raúl Orozco-Díaz (7067624)

    منشور في 2019
    "…<p>(A) Effect of Hsp90α ASO on cell viability. Differentiated SH-SY5Y cells were transfected with different concentrations of Hsp90α ASO. …"
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    Functional Plasmonic Microscope: Characterizing the Metabolic Activity of Single Cells via Sub-nm Membrane Fluctuations حسب Suraj D. Khochare (18288990)

    منشور في 2024
    "…A low-concentration dose showed a reduced fluctuation frequency with consistent fluctuation amplitudes, while the high-concentration dose showcased a decreasing trend in both cases. …"
  16. 96

    Functional Plasmonic Microscope: Characterizing the Metabolic Activity of Single Cells via Sub-nm Membrane Fluctuations حسب Suraj D. Khochare (18288990)

    منشور في 2024
    "…A low-concentration dose showed a reduced fluctuation frequency with consistent fluctuation amplitudes, while the high-concentration dose showcased a decreasing trend in both cases. …"
  17. 97

    Functional Plasmonic Microscope: Characterizing the Metabolic Activity of Single Cells via Sub-nm Membrane Fluctuations حسب Suraj D. Khochare (18288990)

    منشور في 2024
    "…A low-concentration dose showed a reduced fluctuation frequency with consistent fluctuation amplitudes, while the high-concentration dose showcased a decreasing trend in both cases. …"
  18. 98

    Discovery of Novel Acridane-Based Tubulin Polymerization Inhibitors with Anticancer and Potential Immunomodulatory Effects حسب Xiaopeng Peng (9136955)

    منشور في 2022
    "…The most potent compound <b>NT-6</b> exhibited high tubulin polymerization inhibitory activity (IC<sub>50</sub> = 1.5 μM) and remarkable antiproliferative potency against four cancer cell lines with an average IC<sub>50</sub> of 30 nM, better than colchicine and the hit compound <b>1f</b> (IC<sub>50</sub> of 65 and 126 nM, respectively). …"
  19. 99

    Discovery of Novel Acridane-Based Tubulin Polymerization Inhibitors with Anticancer and Potential Immunomodulatory Effects حسب Xiaopeng Peng (9136955)

    منشور في 2022
    "…The most potent compound <b>NT-6</b> exhibited high tubulin polymerization inhibitory activity (IC<sub>50</sub> = 1.5 μM) and remarkable antiproliferative potency against four cancer cell lines with an average IC<sub>50</sub> of 30 nM, better than colchicine and the hit compound <b>1f</b> (IC<sub>50</sub> of 65 and 126 nM, respectively). …"
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