sRNA52320 targets kinases in the LPS-stimulated MAPK signaling pathway and is predicted to attenuate the innate immune response. by Katja Koeppen (226723)

“…<p>(A) Volcano plot of -log₁₀ p-values and mean log₂ ratios for proteins from LPS-stimulated HBE cells transfected with sRNA52320 compared to LPS-stimulated HBE cells transfected with negative control RNA (siNC). …”

Modeling HIV-1 Induced Neuroinflammation in Mice: Role of Platelets in Mediating Blood-Brain Barrier Dysfunction by Letitia D. Jones (2819566)

“…As early as two-weeks post-infection, EcoHIV led to increased permeability of the BBB associated with decreased expression of tight junction protein claudin-5, in CD40L and platelet activation-dependent manner. …”

Tracking POPs in Global Air from the First 10 Years of the GAPS Network (2005 to 2014) by Jasmin K Schuster (11067537)

“…Currently, measurements spanning 5–10 sampling years are available for 40 sites from the GAPS Network. …”

Experimental study on CO₂ absorption in aqueous solutions and water–oil emulsions of TEA and blended MEA/DEA–TEA by Ali Asghar Nozaeim (19432459)

“…The CO₂ absorption capacity in a TEA solution with a low/medium concentration (0.25–0.5 M) is more than the theoretical value while these values are approached to each other in the high concentration (1 M). …”

BMP signaling influences iGluR subtypes distribution. by Mikolaj J. Sulkowski (177479)

“…The relative intensity of postsynaptic GluRIIA and GluRIIB signals decreases unequally in mutants lacking synaptic pMad, and induces a reduction in IIA/IIB ratio, except for <i>gbb</i> mutants (A-B). …”

Mutations in <i>gdf6</i> sensitize SOD1∧G93R zebrafish to develop ALS-like symptoms. by Michèle G. DuVal (278183)

“…Swimming performance was measured in all six genotypes (determined by outcrosses and examining progeny) at 4.5 months of age. <b>A.</b> bigenic fish, i.e. <i>gdf6^−/−</i> mutants expressing SOD1∧G93R, had decreased survival compared to all other genotypes, i.e. their siblings ( = <i>gdf6^+/+</i> or <i>gdf6^+/−</i>) with or without SOD1∧G93R. …”

PI 3-kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNS by Bart Nieuwenhuis (9507389)

“…These findings establish a deficit of axonal PIP3 as a key reason for intrinsic regeneration failure and demonstrate that native p110δ facilitates axon regeneration by functioning in a hyperactive fashion.…”

Effect of hypothermia and/or hypoxia on ALP activity, <i>COL1</i>, and osteocalcin gene expression. by Nick C. Leegwater (3720007)

“…Hypoxia and the combination hypothermia and hypoxia did not affect osteocalcin gene expression. Values are mean ± SEM, from n = 10 of 3 independent experiments using ASCs obtained from 5 stem cell donors *Significant effect of the combination hypothermia and hypoxia compared to hypoxia alone; ^‡Significant effect compared to controls, <i>p</i><0.05. …”

Substructure-based back screening of compound FMP-401319. by Wolfgang Klein (711875)

“…Columns represent mean values of biosynthesis (% of matched DMSO control, red line) calculated out of 5 independent experiments ±SD. …”

Real-world cost-effectiveness of pan-genotypic Sofosbuvir-Velpatasvir combination versus genotype dependent directly acting anti-viral drugs for treatment of hepatitis C patients i... by Yashika Chugh (7325960)

“…The use of SOF+VEL only for cirrhotic patients (scenario II) increases QALYs by 0.28 (0.03 to 0.71) per person, and decreases the cost by ₹ 5,946 (₹ 1,198 to ₹ 14,174) per patient, when compared to scenario I. …”

Deletion of peroxisome proliferator response element (PPRE) sites in mouse <i>Mogat1</i> promoter reduces its transcriptional activity. by Shireesha Sankella (3111030)

“…The PPRE sites I and II were deleted in the -2832/+136 Mogat1 promoter construct. Deletion of site I decreased the luciferase activity to ~7.5-fold and site II to ~15-fold. …”

Cancer cells can produce ATP in response to extracellular acid alone. by Gautam Dhar (723875)

“…<p>(A) Time kinetics of ATP production at pH 7.0. MDA-MB-231 (steady state), at pH 7.5 in glucose-free buffer, were acidified to pH 7.0 at 37°C for the indicated time, quenched with chloroform and the amounts of ATP were determined from the aqueous fraction. …”

Linking neural data with behavioral data in the EVA framework. by Quynh-Anh Nguyen (847240)

“…Averaged spike counts over <i>N</i>_<i>in</i> A1-neurons, , are normal-like distributed with means <i>m</i>_<i>DF</i> and standard deviation decreasing inversely with ; shown in gray (<i>DF</i> = 3), black (<i>DF</i> = 5) and light-gray (<i>DF</i> = 7) for <i>N</i>_<i>in</i> = 10 (upper panel) and <i>N</i>_<i>in</i> = 100 (lower panel). …”

Table_1_Cytokines, Adipokines, and Bone Markers at Rest and in Response to Plyometric Exercise in Obese vs Normal Weight Adolescent Females.docx by Nigel Kurgan (6533759)

“…CTX was similar between groups at rest and decreased (-24%; p < 0.001) 1 h post-exercise. Sclerostin was similar between groups at rest, but there was a significant interaction reflecting a significant increase (+29%; p = 0.04) 5 min post-exercise in the obese group and a non-significant decrease (-13%; p = 0.08) in normal weight controls. …”

Chemical, physical and biological changes of white oat ensiled with different additives by Américo Fróes Garcez Neto (6141833)

“…The non-fiber carbohydrates (NFC) decreased (16.67 to 14.05% DM) and the crude protein (CP) did not change (mean of 8.98% DM) during the aerobic exposure in all silages. …”

Regulation of <i>CXCR4</i> expression affects the proliferation of MSCs in vitro. by Zhiqiang Cao (503623)

“…<p>(<b>A</b>) Viability was decreased in MSCs^{sh<i>CXCR4</i>/GFP} and increased in MSCs<i>^CXCR4</i>^/GFP compared to MSCs^GFP or MSCs^native (control), as measured by the MTT assay (Mean ± SD; n = 6; P<0.05 from NO. 4 to 5 time point). …”

Thermal requirements and estimated number of generations of Neopamera bilobata (Say) in strawberry-producing regions of Brazil by Taciana Melissa de Azevedo Kuhn (4717677)

“…The egg-to-adult duration decreased as temperatures increased, up to 28°C (93.4, 83.2, 43.9, and 31.4 days at 19, 22, 25, and 28°C, respectively). …”

Image_3_Hypoxia Alters Epigenetic and N-Glycosylation Profiles of Ovarian and Breast Cancer Cell Lines in-vitro.TIF by Gordon Greville (9182312)

“…SiRNA transient knock down of GATA2/3 transcription factors resulted in a decrease in the expression of glycosyltransferases ST3GAL4 and MGAT5, which are responsible for sialylation and branching, respectively.…”

Image_2_Hypoxia Alters Epigenetic and N-Glycosylation Profiles of Ovarian and Breast Cancer Cell Lines in-vitro.TIF by Gordon Greville (9182312)

“…SiRNA transient knock down of GATA2/3 transcription factors resulted in a decrease in the expression of glycosyltransferases ST3GAL4 and MGAT5, which are responsible for sialylation and branching, respectively.…”

Table_2_Hypoxia Alters Epigenetic and N-Glycosylation Profiles of Ovarian and Breast Cancer Cell Lines in-vitro.XLSX by Gordon Greville (9182312)

“…SiRNA transient knock down of GATA2/3 transcription factors resulted in a decrease in the expression of glycosyltransferases ST3GAL4 and MGAT5, which are responsible for sialylation and branching, respectively.…”