microRNA-34a-Mediated Down-Regulation of the Microglial-Enriched Triggering Receptor and Phagocytosis-Sensor TREM2 in Age-Related Macular Degeneration - Fig 6 by Surjyadipta Bhattacharjee (3181674)

“…After vacuum evaporation of HFIP, aliquoted peptide was re-suspended with DMSO to 5 mM and diluted to 5 μM into the cell culture media; <b>(B)</b> cells were treated with a scrambled miRNA-34a sequence (miRNA-34a-<b>sc</b>; 30 nM;, control, <b>a-d</b>, middle row); or <b>(C)</b> with an LNA-stabilized miRNA-34a (30 nM; miRNA-34a stressed; <b>a-d</b>; bottom row); treatments were for 24 hr before incubation with 5 uM of Aβ42 (made up as in [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0150211#pone.0150211.ref033" target="_blank">33</a>]) for another 24 hr before assay; MG cells were subsequently stained using a murine amyloid beta MABN10 (red fluorescence λ_max~650 nm; anti-Aβ antibody, clone W0-2; Millipore, Bellerica MA), a TREM-2 antibody (M-227): sc-48765 (green fluorescence; λ_max~510 nm; Santa Cruz, Santa Cruz CA) or DAPI nuclear stain (blue fluorescence; λ_max~470 nm) as in <b><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0150211#pone.0150211.g003" target="_blank">Fig 3</a>;</b> arrows indicate Aβ42 uptake into MG cells; note decreased presence of TREM2 in miRNA-34a treated MG cells (bottom row, panel B) and decrease in ingested Aβ42 peptide within C8B4 cells (<b>C</b>; bottom row, panel <b>d</b>). …”

DBcAMP and glucagon produces a decrease of peripheral insulin sensitivity. by Rita S. Patarrão (737406)

Depletion of Atg5 inhibits IDN5706-induced autophagy, but not EDEM1 degradation. by Viviana A. Cavieres (500139)

Accumulated immature APP in response to IDN5706 is degraded by Atg5-dependent autophagy. by Viviana A. Cavieres (500139)

Decreased IL-17A production by DGKζ deficient <i>i</i>NKT cells following α-GalCer stimulation in vitro. by Jinhong Wu (424170)

Event probability by age and altitude of residence in patients with COVID-19 pneumonia. by Juan Alonso Leon-Abarca (8308005)

“…<p>Panel A-B show that the probability of intubation was higher for patients with DM up to 50 [at <1500 m] [p<0.05] and 65 years [at >1500 m] [p<0.05]. …”

Vaccine-Induced IgG Antibodies to V1V2 Regions of Multiple HIV-1 Subtypes Correlate with Decreased Risk of HIV-1 Infection by Susan Zolla-Pazner (156004)

The complex III turnover is decreased in Myc-ON mice (n = 5) compared with the Myc-OFF (n = 5) or single transgenic mice (Single Tg) (n = 4). by Hyoung-gon Lee (73934)

Loss of <i>FGR41</i> modestly delays hyphal development <i>in vitro</i>. by Andrew S. Wagner (11331477)

Video5_Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex.MOV by Wesam S. Ahmed (10170053)

Loss of <i>Ubr5</i> function resulted in decreased expression of <i>Ptch1</i> and <i>Gli1</i> at E13.5. by Elaine Kinsella (2833466)

Rictor deletion leads to a decrease in B cells in the PB and spleen. by Yingchi Zhang (607489)

Embryonic caffeine exposure leads to a decrease in global DNA methylation. by Daniela L. Buscariollo (140729)

“…<p>DNA was isolated from adult left ventricles of mice treated <i>in utero</i> with caffeine. (A) The percentage of 5-methylcytosine decreased in caff+/+ hearts compared to veh+/+ controls, but no change in global DNA methylation levels was observed in caff+/− hearts compared to veh+/− hearts. …”

Effect of SNX5 S226 phosphorylation on macropinocytosis. by Nao Itai (5954666)

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Changes in the localization of SNX5 S226 mutants. by Nao Itai (5954666)

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Fig 5 - by Irene D. Alabia (9191801)

IL-15 decreased early apoptosis of α-GalCer-treated iNKT cells in SLE patients. by Chien-Ya Hsu (11868746)

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Semi-log plot of the number of cities in IT provinces, <i>N</i>_{<i>c</i>,<i>p</i>}; the provinces are ranked according to their decreasing “order of importance”, for vario... by Marcel Ausloos (748325)

Decreased expression of TCA cycle and ETC enzymes in kidneys from rats administered Tl. by Sho Sugahara (11895828)

DHT increases whereas orchidectomy decreases the seminal vesicle weight in wild-type and SOD1-G93A mice. by Young-Eun Yoo (323357)

“…Conversely, orchidectomy decreased the seminal vesicle weight in both WT mice (28.4±13 mg, <i>p</i><0.0001) and SOD1 mice (20.8±3.5 mg, <i>p</i><0.0001) compared with control WT and SOD1 mice, respectively. …”