Identification of a Hydroxypyrimidinone Compound (<b>21</b>) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure by Wei Meng (505670)

“…Due to the increased polarity at C2, the permeability for these compounds decreased. Further adjustment of the polarity by replacing the N1 2,6-dimethoxyphenyl group with a 2,6-diethylphenyl group and reoptimization for the potency of the C5 pyrroloamides resulted in potent compounds with improved permeability. …”

Bradykinin contributes to NE-mediated lung damage and decreased host tolerance. by Manoranjan Sahoo (189969)

(A) Profile of mean-squared error of elastic-net regression for various values of lambda. by Chan C. Whiting (773096)

“…Thus, for example, the estimated age increases by approximately 1.6 years for every unit increase in absolute monocyte count (the analyte with the largest positive coefficient), holding all other values constant; and decreases by approximately 4.5 years for every unit increase in naïve CD8+ T cells (the analyte with the largest negative coefficient). …”

Silencing <i>ifi202</i> expression decreased T cell proliferation. by Mary Zimmerman (357472)

“…<p><b>A</b>. Silencing of <i>ifi202</i> expression by <i>ifi202</i>-specific shRNA. 5KC cells were transduced with scramble shRNA-expressing lentiviral particles (5KC.scramble) and <i>ifi202</i>-specific shRNA (5KC.ifi202.shRNA), respectively. …”

Sox6 overexpression decreased the multi-lineage differentiation potential in NSPCs. by Shigeki Ohta (233204)

Infectivity of HIV-1 particles decreases upon treatment with MEK inhibitor. by Sheila Mansouri (324272)

PAP decreases expression of HIV-1 proteins without toxicity to cells. by Sheila Mansouri (324272)

<i>Dicer</i> mutant animals show decreased eye size. by Rita Pinter (251068)

Melatonin decreases the viability of BeWo cells under hypoxia/reoxygenation. by Lucas Sagrillo-Fagundes (6194843)

Anti-angiogenic effect of CNT decreased in autophagy- or apoptosis-inhibited cells. by Seung Ya Yang (541930)

PGE₂ decreases <i>Sost</i> expression. by Damian C. Genetos (325684)

Table5_Comprehensive Analysis of the Transcriptome-Wide m6A Methylation Modification Difference in Liver Fibrosis Mice by High-Throughput m6A Sequencing.DOCX by Chang Fan (5305073)

“…Hence, the critical elements of m6A modification, including methyltransferase WTAP, demethylases ALKBH5 and binding proteins YTHDF1 were confirmed by RT-qPCR and Western blot. …”

Expression of <i>Foxf1a</i> and <i>Foxf2</i> in <i>shh^−/−</i> and <i>Tbx5^+/−</i> mutants embryos at E9.5. by Andrew D. Hoffmann (651875)

“…<i>Tbx5</i> heterozygotes expressed <i>Foxf1a</i> at decreased levels specifically in the posterior SHF tissues (C, D), whereas <i>Foxf2</i> expression patterns were unchanged (G, H). …”

Inhibition of MRP1 significantly decreases basal and apoptotic GSH efflux. by Parameswaran G. Sreekumar (176748)

“…GSH release from MRP1-silenced ARPE-19 cells incubated with 150 µM H₂O₂ for 5 h in serum free medium. A significant decrease (P<0.001 vs scrambled control) in GSH release was observed in 5 h. …”

Survivin deletion in beta cells leads to decreased beta-cell mass. by Xiaohong Wu (147036)

“…<p>(a) Male and female mutant mice exhibit decreased beta-cell mass at 2-month of age as compared to controls (n = 5 per genotype). …”

GSK343 decreased viability and proliferation in human neuroblastoma PDX cells. by Laura V. Bownes (10276762)

“…Treatment with GSK343 resulted in significantly decreased migration. (D) After 24 hours of treatment with increasing concentrations of GSK343 (0, 5, 10 μM), COA3 and COA6 cells (4.0 × 10⁴) were plated in Transwell^® inserts and allowed to invade for 1 week through a Matrigel^™ layer. …”

Gal 3/LPS interaction decreases mice resistance to the lethality of LPS. by Marise Lopes Fermino (341245)

Decreased synthesis of HIV-1 particles by PAP reduces productive infection. by Sheila Mansouri (324272)

Transcriptional profiling of SHF from <i>shh^−/−</i> embryos. by Andrew D. Hoffmann (651875)

“…<p>(A) Microdissection for isolation of SHF tissues. …”

HO-1 decreases MMP-1 expression and chondrocytes DNA fragmentation. by Francis Rousset (424375)