PPA of Aptima^® SARS-CoV-2 assay as function of neat Fusion^® C_T. by Rudolph Park (14070418)

Fig 5 - by Henlay J. O. Magara (9972716)

Food is necessary for normal levels of male-male aggression but not male-male courtship and its effects are independent from locomotion or encounter duration. by Rod S. Lim (622045)

Structure-Guided Discovery of Potent and Selective CLK2 Inhibitors for the Treatment of Knee Osteoarthritis by Yongqiang Sun (8226111)

“…Among them, compound <b>LQ23</b> showed more elevated inhibitory activity against CLK2 than the lead compound (IC₅₀, 1.4 nM) with high CLK2/CLK3 selectivity (>70-fold). Furthermore, <b>LQ23</b> showed outstanding antiosteoarthritis effects <i>in vitro</i> and <i>in vivo</i>, with the roles specific in decreased inflammatory cytokines, downregulated cartilage degradative enzymes, and increased joint cartilage via suppressing CLK2/Wnt signaling pathway. …”

Structure-Guided Discovery of Potent and Selective CLK2 Inhibitors for the Treatment of Knee Osteoarthritis by Yongqiang Sun (8226111)

“…Among them, compound <b>LQ23</b> showed more elevated inhibitory activity against CLK2 than the lead compound (IC₅₀, 1.4 nM) with high CLK2/CLK3 selectivity (>70-fold). Furthermore, <b>LQ23</b> showed outstanding antiosteoarthritis effects <i>in vitro</i> and <i>in vivo</i>, with the roles specific in decreased inflammatory cytokines, downregulated cartilage degradative enzymes, and increased joint cartilage via suppressing CLK2/Wnt signaling pathway. …”

Structure-Guided Discovery of Potent and Selective CLK2 Inhibitors for the Treatment of Knee Osteoarthritis by Yongqiang Sun (8226111)

“…Among them, compound <b>LQ23</b> showed more elevated inhibitory activity against CLK2 than the lead compound (IC₅₀, 1.4 nM) with high CLK2/CLK3 selectivity (>70-fold). Furthermore, <b>LQ23</b> showed outstanding antiosteoarthritis effects <i>in vitro</i> and <i>in vivo</i>, with the roles specific in decreased inflammatory cytokines, downregulated cartilage degradative enzymes, and increased joint cartilage via suppressing CLK2/Wnt signaling pathway. …”

Structure-Guided Discovery of Potent and Selective CLK2 Inhibitors for the Treatment of Knee Osteoarthritis by Yongqiang Sun (8226111)

“…Among them, compound <b>LQ23</b> showed more elevated inhibitory activity against CLK2 than the lead compound (IC₅₀, 1.4 nM) with high CLK2/CLK3 selectivity (>70-fold). Furthermore, <b>LQ23</b> showed outstanding antiosteoarthritis effects <i>in vitro</i> and <i>in vivo</i>, with the roles specific in decreased inflammatory cytokines, downregulated cartilage degradative enzymes, and increased joint cartilage via suppressing CLK2/Wnt signaling pathway. …”

Figure 5 by Jian Jiao (364961)

“…<p>(<b>A</b>, <b>B</b>) hPGRN-3T3 cells were transfected with miR-29b or negative control mimics, and the relative hPGRN levels in total cell lysates (<b>A</b>) and medium (<b>B</b>) were determined by ELISA. …”

T1-Weighted Magnetic Resonance Imaging (MRI). by Lu Xu (386491)

Combination of DNA Damage, Autophagy, and ERK Inhibition: Novel Evodiamine-Inspired Multi-Action Pt(IV) Prodrugs with High-Efficiency and Low-Toxicity Antitumor Activity by Xiao-Meng Liu (778197)

“…Among them, compound <b>10</b> exhibited a 118-fold enhancement in the IC₅₀ value compared to cisplatin and low toxicity to normal cells. …”

Combination of DNA Damage, Autophagy, and ERK Inhibition: Novel Evodiamine-Inspired Multi-Action Pt(IV) Prodrugs with High-Efficiency and Low-Toxicity Antitumor Activity by Xiao-Meng Liu (778197)

“…Among them, compound <b>10</b> exhibited a 118-fold enhancement in the IC₅₀ value compared to cisplatin and low toxicity to normal cells. …”

Combination of DNA Damage, Autophagy, and ERK Inhibition: Novel Evodiamine-Inspired Multi-Action Pt(IV) Prodrugs with High-Efficiency and Low-Toxicity Antitumor Activity by Xiao-Meng Liu (778197)

“…Among them, compound <b>10</b> exhibited a 118-fold enhancement in the IC₅₀ value compared to cisplatin and low toxicity to normal cells. …”

Combination of DNA Damage, Autophagy, and ERK Inhibition: Novel Evodiamine-Inspired Multi-Action Pt(IV) Prodrugs with High-Efficiency and Low-Toxicity Antitumor Activity by Xiao-Meng Liu (778197)

“…Among them, compound <b>10</b> exhibited a 118-fold enhancement in the IC₅₀ value compared to cisplatin and low toxicity to normal cells. …”

Combination of DNA Damage, Autophagy, and ERK Inhibition: Novel Evodiamine-Inspired Multi-Action Pt(IV) Prodrugs with High-Efficiency and Low-Toxicity Antitumor Activity by Xiao-Meng Liu (778197)

“…Among them, compound <b>10</b> exhibited a 118-fold enhancement in the IC₅₀ value compared to cisplatin and low toxicity to normal cells. …”

Efficiency of plaque formation. by Yuan Tian (225002)

Characterization of Inflammatory Mediators and Metabolome in Interstitial Fluid Collected with Dermal Open Flow Microperfusion before and at the End of Dupilumab Treatment in Atopi... by Fernanda Monedeiro (17282350)

“…At v10 versus v2, the percentages of CD4+ interleukin-producing cells showed a decreasing trend in ISF L and NL, unbound IL-4 levels in plasma were increased, IL-5 levels in ISF L reduced, and levels of factors involved in anti-inflammatory pathways and re-epithelization increased. …”

Characterization of Inflammatory Mediators and Metabolome in Interstitial Fluid Collected with Dermal Open Flow Microperfusion before and at the End of Dupilumab Treatment in Atopi... by Fernanda Monedeiro (17282350)

“…At v10 versus v2, the percentages of CD4+ interleukin-producing cells showed a decreasing trend in ISF L and NL, unbound IL-4 levels in plasma were increased, IL-5 levels in ISF L reduced, and levels of factors involved in anti-inflammatory pathways and re-epithelization increased. …”

Characterization of Inflammatory Mediators and Metabolome in Interstitial Fluid Collected with Dermal Open Flow Microperfusion before and at the End of Dupilumab Treatment in Atopi... by Fernanda Monedeiro (17282350)

“…At v10 versus v2, the percentages of CD4+ interleukin-producing cells showed a decreasing trend in ISF L and NL, unbound IL-4 levels in plasma were increased, IL-5 levels in ISF L reduced, and levels of factors involved in anti-inflammatory pathways and re-epithelization increased. …”

Fig 5 - by Qian Du (280345)

High numbers of differentiated CD28null CD8+ T cells are associated with a lowered risk for late rejection and graft loss after kidney transplantation by Michiel G. H. Betjes (8407413)

“…</p><p>Methods</p><p>Recipients of a kidney transplant in the period 2007–2013 were (N = 365) were included. …”