Image_1_Small Peptide Derivatives Within the Carbohydrate Recognition Domain of SP-A2 Modulate Asthma Outcomes in Mouse Models and Human Cells.tiff by Dave Francisco (1328862)

“…Given this activity, we developed 10 and 20 amino acid peptides of SP-A2 spanning position 223Q. We show that the SP-A 223Q peptides reduce eosinophilic inflammation, mucin production and airways hyperresponsiveness in a house dust mite model of asthma, protect from lung function decline during an IL-13 challenge model in mice, and decrease IL-13-induced MUC5AC gene expression in primary airway epithelial cells from asthmatic participants. …”

Image_2_Small Peptide Derivatives Within the Carbohydrate Recognition Domain of SP-A2 Modulate Asthma Outcomes in Mouse Models and Human Cells.tiff by Dave Francisco (1328862)

“…Given this activity, we developed 10 and 20 amino acid peptides of SP-A2 spanning position 223Q. We show that the SP-A 223Q peptides reduce eosinophilic inflammation, mucin production and airways hyperresponsiveness in a house dust mite model of asthma, protect from lung function decline during an IL-13 challenge model in mice, and decrease IL-13-induced MUC5AC gene expression in primary airway epithelial cells from asthmatic participants. …”

Table_5_Does Prefrontal Glutamate Index Cognitive Changes in Parkinson’s Disease?.docx by Isabelle Buard (6375827)

Localization of CCL2 and CCR2 after spinal cord injury (SCI). by Kazumichi Yagura (4537504)

“…<p><b>(A)</b> CCL2⁺ cells (<i>green</i>) were observed around the site of SCI on day 1 and were merged with the neuronal marker NeuN (<i>red</i>) (arrows). …”

Trip characteristics comparing < 5-month-old pups (this study) to all other age classes [26, 37] including trip duration (d), surface speed (km h^-1), distance to shore (... by Benia V. R. Nowak (17054285)

Table 1_Imeglimin may affect hemoglobin A1c accuracy via prolongation of erythrocyte lifespan in patients with type 2 diabetes mellitus: insights from the INFINITY clinical trial.d... by Takeshi Osonoi (1951555)

“…</p>Results<p>The change in hemoglobin concentration at 6 months was not statistically significant (mean ± SD: −0.2 ± 0.9 g/dL; p = 0.23). While HbA1c and GA decreased and 1,5-AG increased one month after imeglimin initiation, GA and 1,5-AG showed rapid changes compared to the gradual decrease in HbA1c. …”

Image_5_Heterogeneity in the isolation of patches may be essential for the action of metacommunity mechanisms.JPEG by Ana I. Borthagaray (14952037)

Transcriptomic, cellular and life-history responses of <i>Daphnia magna</i> chronically exposed to benzotriazoles: Endocrine-disrupting potential and molting effects by Maeva Giraudo (342875)

“…BTR induced the transcription of genes involved in 20-hydroxyecdysone synthesis, which suggests pro-ecdysteroid properties. 5ClBTR exposure induced protein activity and transcriptional levels of chitinase enzymes, associated with an impact on ecdysteroid signaling pathways, which could explain the decrease in molt frequency. …”

Image_2_Reduced Expression of METTL3 Promotes Metastasis of Triple-Negative Breast Cancer by m6A Methylation-Mediated COL3A1 Up-Regulation.JPEG by Yu Shi (117923)

“…Further investigation showed that knockdown of METTL3 could enhance the ability of migration, invasion, and adhesion by decreasing m6A level in TNBC cell lines. Collagen type III alpha 1 chain (COL3A1) was identified and verified as a target gene of METTL3. …”

Image_1_Reduced Expression of METTL3 Promotes Metastasis of Triple-Negative Breast Cancer by m6A Methylation-Mediated COL3A1 Up-Regulation.JPEG by Yu Shi (117923)

“…Further investigation showed that knockdown of METTL3 could enhance the ability of migration, invasion, and adhesion by decreasing m6A level in TNBC cell lines. Collagen type III alpha 1 chain (COL3A1) was identified and verified as a target gene of METTL3. …”

Table_1_Reduced Expression of METTL3 Promotes Metastasis of Triple-Negative Breast Cancer by m6A Methylation-Mediated COL3A1 Up-Regulation.XLS by Yu Shi (117923)

“…Further investigation showed that knockdown of METTL3 could enhance the ability of migration, invasion, and adhesion by decreasing m6A level in TNBC cell lines. Collagen type III alpha 1 chain (COL3A1) was identified and verified as a target gene of METTL3. …”

A Pilot Trial Assessing Urinary Gene Expression Profiling with an mRNA Array for Diabetic Nephropathy by Min Zheng (131026)

“…Among these genes, α-actinin4, CDH2, ACE, FAT1, synaptopodin, COL4α, twist, NOTCH3 mRNA expression were 15-fold higher than those in normal controls. In contrast, urinary TIMP-1 mRNA was significantly decreased in DN patients (p<0.05). …”

Table_5_Lactitol Supplementation Modulates Intestinal Microbiome in Liver Cirrhotic Patients.docx by Haifeng Lu (465603)

ATF4 target genes activated in ΔLMP1 EBV-infected NOKs. by Deo R. Singh (4784112)

Relationship between social context-dependent changes (from undirected (UD) to female-directed (FD) song) to transitions probabilities and gap durations. by Andrew M. M. Matheson (835763)

“…Data on transition probabilities at branch points from [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0143203#pone.0143203.ref035" target="_blank">35</a>].…”

Table_5_Seasonal Differences in Structural and Genetic Control of Digestibility in Perennial Ryegrass.xlsx by Vincent Colas (5590772)

HIV Clinical Pathway: A New Approach to Combine Guidelines and Sustainability of Anti-Retroviral Treatment in Italy by Davide Croce (383177)

“…CD4⁺ cell counts increased by 28 ± 4 cells/mm³ in Pre-CP Phase and 39 ± 5 cells/mm³ in Post-CP Phase. From an economic point of view, the CP implementation led to a substantial advantage: the mean total costs related to the management of the HIV disease (ART, hospital admission and laboratory tests) decreased (-8.60%) in the Post-CP phase (p-value < 0.0001). …”

Data_Sheet_1_A Novel Dnmt3a1 Transcript Inhibits Adipogenesis.docx by Bahareldin A. Abdalla (5809958)

“…<p>DNA (cytosine-5)-methyltransferase 3a (Dnmt3a) is an enzyme that catalyzes the transfer of methyl groups to specific CpG forms in DNA. …”

Image_5_Differential Regulation of Microglial Activation in Response to Different Degree of Ischemia.tif by Hao Gao (154820)

Table_5_The T Cell Receptor Immune Repertoire Protects the Liver From Reconsitution.xlsx by Qing Liang (654718)

“…Furthermore, we uncovered a novel fibrosis-associated CD8 T (Ccl5⁺, Ccl4⁺) and CD4 T (mt-Co1⁺) cell subpopulation, which infiltrates fibrotic liver and is characterized by abnormal activation or inactivation as well as a TCR decline. …”