Isomeric Mono-, Di-, and Tri-Bromobenzo-1H-Triazoles as Inhibitors of Human Protein Kinase CK2α by Romualda Wąsik (119538)

“…The decrease in pK_a on halogenation of the peripheral C(4)/C(7) atoms virtually nullifies the gain due to hydrophobic interactions, and does not lead to a decrease in IC₅₀. …”

Histone 3 acetylation correlates with target gene expression of Srf and Gata4. by Jenny Schlesinger (229807)

“…Genes marked by Mef2a or Nkx2.5 show significant increased expression levels compared to non-marked genes (Ref) independent of co-occurring H3ac. …”

Data_Sheet_1_Biological Characterization of Hepatitis B virus Genotypes: Their Role in Viral Replication and Antigen Expression.docx by María Mercedes Elizalde (5184335)

“…Genotype A2 expressed the lowest pgRNA levels, with a 70-fold decrease in relation to the other genotypes (p<0.0001), while genotype B2 showed the lowest Precore RNA levels, with a 100-fold reduction compared to genotype A2 (p<0.0001). …”

Challenge with P. gingivalis W83 Strain Elicits Potent Neutrophil Recruitment and Activation in the Peripheral Blood Compared to the Rbr⁻ Strain by Piotr Mydel (19843)

“…The histograms in the bottom row exhibit a two-fold decrease in CD62L expression for peripheral blood neutrophils collected from (F) W83-challenged mice in comparison to (D) control and (E) the <i>rbr⁻</i> mutant strain–infected animals. …”

Genes differentially expressed in response to heat-shock-induced overexpression of , grouped according to functional classes by Ronny Leemans (54731)

“…Positive values indicate that the relative expression level of a gene is increased (upregulated) following overexpression and negative values indicate a decrease (downregulated). …”

DataSheet1_Dosage Modification of Traditional Chinese Medicine Prescriptions: An Analysis of Two Randomized Controlled Trials.docx by Rongrong Zhou (3341903)

“…In Study 1, the correlation analysis between the change range of indicators at three time points (weeks 4, 8, and 12) from baseline and the decrease in HbA1c at week 12 from baseline (HbA1c 012) was carried out to screen the related indications. …”

DataSheet1_Dosage Modification of Traditional Chinese Medicine Prescriptions: An Analysis of Two Randomized Controlled Trials.docx by Rongrong Zhou (3341903)

“…In Study 1, the correlation analysis between the change range of indicators at three time points (weeks 4, 8, and 12) from baseline and the decrease in HbA1c at week 12 from baseline (HbA1c 012) was carried out to screen the related indications. …”

Volcano plot of cell type specific genes. by Nelson T. Gross (9028031)

“…The two vertical lines indicate a threshold of log₂ fold of difference of -1 (left) or +1 (right). …”

Loss of auditory function and the generation of sensory cell apoptosis following exposure to noise. by Minal Patel (385459)

“…Similar changes were noted at 2 h post-noise exposure (data not shown). Single arrows point to condensed OHC nuclei showing an increase in staining intensity with or without a decrease in nuclear size. …”

Choosing the best heuristic for seeded alignment of DNA sequences-1 by Yanni Sun (27928)

“…For each curve, the subsequent points decrease by 1 while holding constant. Each point represents a locally optimal set of seeds.…”

The influence of the abdominal body segments on NMJ features. by Bonnie Nijhof (478491)

“…The third category (green) includes the muscle area (G), that shows a significant increase in values from A2 to A3 and a significant decrease from A3 to A5. …”

Early isolates of HIV-1 from the blood are deficient in binding and/or fusion with CD4 from some primate species. by Cody J. Warren (563898)

“…<p>(A) 293T cells transiently expressing various Envelope proteins (Envs), and dog thymocytes (Cf2Th cells) stably expressing various primate CD4 receptors and human CCR5, were each transfected with plasmids encoding half of a split Renilla luciferase [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3000304#pbio.3000304.ref079" target="_blank">79</a>]. …”

Independent experiment confirming that viral IE2 depletion in late infection does not affect viral long promoter transcription. by Qiaolin Hu (8677473)

“…(<b>A</b>) Western blot analysis shows that the dTag degrader decreased IE2^F-86 amount by 88%, compared to CTRL and normalized to the host actin control. …”

Tumor microenvironment facilitates the emergence of high levels of drug resistance. by Feng Fu (218124)

“…In the absence of drugs, both proliferation and turnover rates of cancer cells decrease with <i>x</i> [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004142#pcbi.1004142.ref022" target="_blank">22</a>]: birth rate <i>β</i>(<i>x</i>) = <i>b</i>₀exp(−<i>x</i>/<i>τ</i>_<i>g</i>) and death rate <i>α</i>(<i>x</i>) = <i>d</i>₀exp(−<i>x</i>/<i>τ</i>_<i>g</i>), where the parameter <i>τ</i>_<i>g</i> is the characteristic length scale of spatial decay in proliferation and turnover rates. …”

Effect of Protonation upon Electronic Coupling in the Mixed Valence and Mixed Protonated Complex, [Ni(2,3-pyrazinedithiol)₂] by Steven R. Kennedy (1405423)

“…We characterize the structural, electronic, vibrational, and magnetic properties of this complex in five different states, including the mixed valence and MVMP states, and then analyze the intervalence charge transfer (IVCT) band to demonstrate a five-fold reduction in electronic coupling upon protonation. …”

Effect of Protonation upon Electronic Coupling in the Mixed Valence and Mixed Protonated Complex, [Ni(2,3-pyrazinedithiol)₂] by Steven R. Kennedy (1405423)

“…We characterize the structural, electronic, vibrational, and magnetic properties of this complex in five different states, including the mixed valence and MVMP states, and then analyze the intervalence charge transfer (IVCT) band to demonstrate a five-fold reduction in electronic coupling upon protonation. …”

Assembly-induced changes in the rotation curve. by Rifka Vlijm (133750)

“…NAP1 incubated with all 4 core histones induces positive supercoils and decreases the DNA end-to-end length. At point a, the maximum of the rotation curve before assembly, ΔL_k = 0 since magnets are not rotated, ΔL_k,nuc = 0 since no nucleosomes are formed yet and ΔL_k,DNA = 0 by definition at the peak of the rotation curve. …”

Stereoselective Alkali-Metal Catalysts for Highly Isotactic Poly(<i>rac</i>-lactide) Synthesis by Yangyang Sun (1446925)

“…The isoselective mechanism is chain-end control through the analysis of the stereoerrors in the microstructure of a final polymer; thus, isotactic multiblock structure polymers are obtained, and the highest melt point can reach 192.5 °C. …”

Stereoselective Alkali-Metal Catalysts for Highly Isotactic Poly(<i>rac</i>-lactide) Synthesis by Yangyang Sun (1446925)

“…The isoselective mechanism is chain-end control through the analysis of the stereoerrors in the microstructure of a final polymer; thus, isotactic multiblock structure polymers are obtained, and the highest melt point can reach 192.5 °C. …”

Stereoselective Alkali-Metal Catalysts for Highly Isotactic Poly(<i>rac</i>-lactide) Synthesis by Yangyang Sun (1446925)

“…The isoselective mechanism is chain-end control through the analysis of the stereoerrors in the microstructure of a final polymer; thus, isotactic multiblock structure polymers are obtained, and the highest melt point can reach 192.5 °C. …”