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point decrease » point increase (Expand Search)
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70761
Interactions of Prototype Foamy Virus Capsids with Host Cell Polo-Like Kinases Are Important for Efficient Viral DNA Integration
Published 2016“…Although STP motif mutated viruses displayed wild type (wt) particle release, RNA packaging and intra-particle reverse transcription, their replication capacity was decreased 3-fold in single-cycle infections, and up to 20-fold in spreading infections over an extended time period. …”
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70762
GJ inhibition is the key driver of single-cell Ca<sup>2+</sup> spike activity.
Published 2021“…<b>(B-E)</b> <i>K</i><sub><i>PLC</i></sub> is increased left-to-right (red bar), and gap junction communication is decreased left-to-right (blue bar). An increase in <i>K</i><sub><i>PLC</i></sub> results in a decrease in frequency, while decrease in gap junction communication results in single-cell Ca<sup>2+</sup> spikes (red arrows).…”
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70763
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70764
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70765
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70766
Modeling of pairing kinetics at reduced DSB abundance.
Published 2024“…Translational movement velocity is reduced to 77% of wild type levels (230 nm/s), consistent with slower chromosome movements observed in <i>spo11</i> [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1011416#pcbi.1011416.ref015" target="_blank">15</a>], and attractive force is reduced 3-fold representing decreased attractive forces exerted by fewer DSBs (see <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1011416#pcbi.1011416.t001" target="_blank">Table 1</a>). …”
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70767
Monte Carlo simulation study results examining model robustness.
Published 2013“…<p>Median relative bias and estimated coverage of asymptotic 95% confidence intervals for estimated total annual abundance for simulated small game data from simulations designed to address robustness. “Increasing S” (“Decreasing S”) scenario corresponds to a population with natural survival probability gradually increasing (decreasing) over the study period. …”
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70768
Influence of <i>k</i><sub>1</sub> on the homeostatic behavior of the m7 ping-pong controller when <i>E</i><sub>1</sub> binds first to free enzyme <i>Ez</i>.
Published 2022“…(c) A decrease of <i>k</i><sub>6</sub> from 5.0 to 1.0 while <i>k</i><sub>1</sub> is kept at 100.0 gives a general improvement of the homeostatic performance of the ping-pong controller, except for the higher end <i>k</i><sub>5</sub> range between 900–1000, where <i>A</i><sub><i>ss</i></sub> becomes constant (indicated by the red circle). …”
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70769
<i>Drosophila</i> peroxisomal gene networks.
Published 2017“…These <i>Drosophila</i> peroxisomal genes are clustered in 5 co-regulated gene clusters that were subsequently used to identify the top 1000 genes for each cluster that has a similar expression pattern from <i>Drosophila</i> gene expression data-sets. …”
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70770
Colocalization of the lipid and MinD spirals
Published 2011“…Images B and E show the FM 4-64 (acceptor) fluorescence signal before and after photobleaching. A decrease in intensity can clearly be seen within the marked region. …”
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70771
Aerofoil Design for Unmanned High-Altitude Aft-Swept Flying Wings
Published 2017“…The second part contains the optimisation code using a genetic algorithm. The primary target here was to design a number of aerofoils with low pitching moment, suitable for an aft-swept flying wing configuration operating at low Reynolds number in the range of about 0.5 × 106. …”
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70772
SCS Designs 6, 7, and 8.
Published 2014“…We tested various lengths for the substrate binding arms of the upstream DNAzyme (denoted as 5′/3′ in the Figure). These results showed that longer substrate binding arms decrease the effect on activation rate by reducing the rate of product dissociation. …”
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70773
Measured Physical Activity Age
Published 2022“…We performed a genome wide association on the accelerated aging phenotypes to estimate its heritability (h_g2=12.3±0.9%) and identified ten single nucleotide polymorphisms in close proximity to genes in a histone and olfactory cluster on chromosome six (e.g <em>HIST1H1C, OR5V1</em>). …”
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70774
VEGF knockdown podocyte model.
Published 2012“…Bar graphs show densitometric analysis of ≥3 immnublots/protein expressed as fold change mean ±SEM. (E) VEGF-A knockdown changed VEGF<sup>KD</sup> podocyte shape and decreased their size, assessed by rhodamine phalloidin staining, which were reversible upon exposure to recombinant VEGF<sub>165</sub>. …”
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70775
The NH<sub>2</sub>-terminus of PDX-1 binds to <i>Krt19</i> promoter DNA.
Published 2010“…C) MIN6 cells were transfected with V5-tagged full length PDX-1 or PDX-1 Δ1-37. DNA precipitation was carried out as described above, and membranes were probed with anti-V5. …”
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70776
Data_Sheet_1_SUMOylation of Alpha-Synuclein Influences on Alpha-Synuclein Aggregation Induced by Methamphetamine.doc
Published 2018“…Levels of the ubiquitin-proteasome system (UPS)-related makers ubiquitin (Ub) and UbE1, as well as the autophagy-lysosome pathway (ALP)-related markers LC3, P62 and lysosomal associated membrane protein 2A (LAMP2A), were also measured in SH-SY5Y cells transfected with lentivirus and mice injected with adenovirus. …”
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70777
Molecular Characterization of Acquired Tolerance of Tumor Cells to Picropodophyllin (PPP)
Published 2011“…Using Nexus software analysis we combined the array-CGH data with data from gene expression profilings and identified genes that were altered in both inputs. A subset of genes identified as downregulated (<em>ALDH1A3</em>, <em>ANXA1</em>, <em>TLR4</em> and <em>RAB5A</em>) or upregulated (<em>COX6A1</em>, <em>NFIX</em>, <em>ME1</em>, <em>MAPK</em> and <em>TAP2</em>) were validated by siRNA in the tolerant or parental cells to alter sensitivity to PPP and confirmed to alter sensitivity to PPP in further cell lines.…”
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70778
Metabolomics raw data and table of extracted peak areas for BT478, BT530 and NHA cells cultured in the presence of MPA, Compound 3 (IC80) or vehicle control, for 6 hours.
Published 2024“…The linear gradient employed was as follows: 0–2.5 min 99% A, 2.5–7.5 min decrease to 80% A, 7.5–13 min to 55% B 652 and finally 13–15 min to 99% B and held for 1 min. …”
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70779
Table_1_Regulation of miRNA expression in the prefrontal cortex by fecal microbiota transplantation in anxiety-like mice.docx
Published 2024“…MiRNA analysis identified five key miRNAs affecting GAD pathogenesis, including mmu-miR-10a-5p, mmu-miR-1224-5p, mmu-miR-218-5p, mmu-miR-10b-5p, and mmu-miR-488-3p. …”
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70780
Presentation_1_Selective Heart Irradiation Induces Cardiac Overexpression of the Pro-hypertrophic miR-212.PPTX
Published 2019“…</p><p>Results: In RIHD, diastolic dysfunction was present at every time point. Septal hypertrophy developed at week 3 and a marked LVH with interstitial fibrosis developed at week 19 in the irradiated hearts. …”