Anti-TNF Thioester Glucocorticoid Antibody–Drug Conjugate Fully Inhibits Inflammation with Minimal Effect on Systemic Corticosterone Levels in a Mouse Arthritis Model by Christopher C. Marvin (1338228)

“…Mouse PK indicated that <b>6</b> is cleared 10-fold more rapidly than a first-generation GRM payload, resulting in 10-fold lower exposure and 3-fold decrease in Cmax. …”

Anti-TNF Thioester Glucocorticoid Antibody–Drug Conjugate Fully Inhibits Inflammation with Minimal Effect on Systemic Corticosterone Levels in a Mouse Arthritis Model by Christopher C. Marvin (1338228)

“…Mouse PK indicated that <b>6</b> is cleared 10-fold more rapidly than a first-generation GRM payload, resulting in 10-fold lower exposure and 3-fold decrease in Cmax. …”

MVEC microvessel formation is restricted in hydrogels exhibiting increased stiffness or decreased concentration of adhesive peptides. by Rebecca A. Scott (488956)

“…An unpaired student’s t-test detect statistical significance, *p<0.05 for 7.5 wt% hydrogels containing 3 mM RGD relative to either (<b>A, C-F</b>) 15wt% hydrogels containing 3 mM RGD or (<b>G, I-L</b>) 7.5wt% hydrogels containing 1 mM RGD.…”

Nsp8 decreases antiviral immune and inflammatory responses and promotes SARS-CoV-2 infection. by Xiaolin Zhang (246784)

The deletion of the <i>pflB</i> gene led to decreased invasion efficiency in the Caco-2 cell line, which corresponded to a reduced organ burden in C57BL/6 mice five days after infection through oral gavaging. by Debapriya Mukherjee (9961289)

Impact of decreased PG synthesis on <i>A</i>. <i>tumefaciens</i>. by Michelle A. Williams (8446437)

IFN-β signalling pathway stimulation by Poly(I:C) decreased 5’terminally deleted CVB3 RNA forms viral loads, cardiac lesions and mortality in DBA/2J mice. by Domitille Callon (17723936)

Increased sorting endosome size and decreased EHD1 recruitment upon Rabenosyn-5 knock-down. by Tyler Jones (4507858)

Graphs of marginal mean values of the studied parameters for dolphin kick, flutter kick and breaststroke kick with and without diving gear (Parameters that were not statistically d... by Marek Rejman (9199616)

TG6-44 treatment leads to a decrease in NP-positive cells and altered expression patterns of NP in A/X31 infected THP-1 cells. by Juan A. De La Cruz (11154187)

Incidence and fitting values of Hepatitis predicted by three neural network models. by Zhaohui Xia (9406284)

RNN models. by Zhaohui Xia (9406284)

Prediction performance of the three neural network models. by Zhaohui Xia (9406284)

Graphs showing the mean maximum temperature increase at the position with the highest mean temperature increase (A) and the mean temperature increase across all probes (B) for each... by Marsel Ganeyev (21453399)

Preoperative and postoperative scores for the different dimensions of BAROS scores in groups A, B, C D, E, F, and G. by Régis Cohen (11419436)

Time concordance metrics for all TFs, pathways as well as genes using both a minimal |logFC| of 0.5 and 1. by Anika Liu (8411805)

Decreased hyper-resection in a NuA4 acetylation defective mutant in G1 and defect in DNA break repair by SSA. by Salar Ahmad (11457776)

“…(F) The <i>esa1-ts</i> mutation leads to a decrease of DSB repair by resection-based single-strand annealing. …”

CRP decreases histone H4-enhanced IAV aggregation, as well as IAV neutralizing activity and increased neutrophil uptake of IAV caused by H4. by I-Ni Hsieh (4971679)

A prepubertal CD decreases plasma leptin and cholesterol concentrations in adulthood despite a chronic HFD in Sprague-Dawley male rats. by Ana Aguilar-Lozano (20614619)

Methamphetamine exposure decreases midbrain neuronal activity via a D₂ receptor mechanism. by Douglas R. Miller (7406591)