Effect of PEG-8000 on EGFR, cyclin D1 and p21 expression in SCC-25 cells-For these studies, western blot analysis was performed on lysates obtained from SCC-25 cell treated for 24... by Ramesh K. Wali (305603)

“…<p>As shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0038047#pone-0038047-g005" target="_blank">Figure 5A</a>, consonant with the <i>in vivo</i> experiments PEG caused a significant decrease EGFR (∼45% compared to vehicle control; p<002) and cyclin D1 (∼57% compared to control vehicle; p<0.005) expression. …”

Transducer mechanisms activated by D1-like receptors. by Catalina Valdés-Baizabal (701863)

“…The use of H89 in the intracellular solution decreased the inhibitory effect of A-68930 from 29 ± 4% to 16 ± 5% at −10 mV (<i>P</i> = 0.08). …”

Evolutionary Consequences of Altered Atmospheric Oxygen in <em>Drosophila melanogaster</em> by Marc Charette (198776)

“…<div><p>Twelve replicate populations of <em>Drosophila melanogaster</em>, all derived from a common ancestor, were independently evolved for 34+ generations in one of three treatment environments of varying PO₂: hypoxia (5.0–10.1 kPa), normoxia (21.3 kPa), and hyperoxia (40.5 kPa). …”

Treatment of landfill leachate using Fenton Processes and Photo-Fenton Solar by Fábio Moraes da Costa (5376350)

“…These conditions led to a decrease in the toxicity of leachates' coefficient values to a degree equal to 50 % - for Aliivibrio fischeri greater than 50% - indicating a more suitable leachate for further biological treatment.…”

<i>Def6</i> RNA rescues the <i>def6</i> MO-induced phenotype. by Katerina Goudevenou (199855)

“…ANOVA single factor and two-tailed Student's <i>t</i>-tests showed a significant (p<0.001; three asterisks) increase in the angle after injection of 2.5 ng <i>def6</i> MO and a significant (p<0.001; three asterisks) decrease in the angle after addition of <i>def6</i> RNA. …”

X-ray solution scattering analysis indicating that fragmentation is radiation dose dependent. by Timothy R. Stachowski (9652625)

“…EndoH_CYS was irradiated at pH 7.5 and the results shown are averages of two replicates at a concentration of 5.0 mg/ml. …”

Gradual increase in the extent of γ-secretase saturation with its substrate leads to gradual changes from the biphasic to the standard dose-response curves. by Željko M. Svedružić (105215)

“…Further increase in the substrate (i.e. cDNAwtC99 >250 ng/mL) leads to decrease in Aβ 1–40 secretion (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0050759#pone-0050759-t002" target="_blank">Table 2B</a>), which indicates that the substrate can also bind to the inhibition site (i.e. antagonism between complex <b><u>5</u></b> and complex <b><u>6</u></b>).…”

DataSheet_1_In Vivo Characterization of Cortical and White Matter Microstructural Pathology in Growth Hormone-Secreting Pituitary Adenoma.pdf by Taoyang Yuan (8470440)

“…</p>Results<p>Compared to controls, we found 1) acromegaly had significantly increased cortical thickness throughout the bilateral cortex (pFDR < 0.05). 2) T1/T2-weighted ratio in the cortex were decreased in the bilateral occipital cortex and pre/postcentral central gyri but increased in the bilateral fusiform, insular, and superior temporal gyri in acromegaly (pFDR < 0.05). 3) T1/T2-weighted ratio were decreased in most bundles, and only a few areas showed increases in acromegaly (pFDR < 0.05). 4) Neurite density index (NDI) was significantly lower throughout the cortex and bundles in acromegaly (pTFCE < 0.05). 5) lower fractional anisotropy (FA) and higher mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD) in extensive bundles in acromegaly (pTFCE < 0.05). 6) microstructural pathology in the cortex and white matter were associated with neuropsychological dysfunction in acromegaly.…”

Effect of ASM-024 on lung tissue resistance in response to methacholine. by Evelyne Israël Assayag (512451)

“…A single 5 minutes exposure to 1.5 mg/kg nebulized ASM-024 prior to the methacholine challenge significantly decreased airway resistance in OVA-sensitized mice; p<0.05 for 0.06, 0.125, 0.25 and 1 mg/kg methacholine (A). …”

Downregulation of <i>let-7</i> miRNAs is associated with <i>C. parvum</i>-induced exosome release from epithelial cells. by Guoku Hu (186912)

“…H69 monolayers were treated with a non-specific anti-miR control or anti-<i>let-7i</i> or <i>let-7i</i> precursor, followed by exposure to <i>C. parvum</i> infection for 24 h. …”

Expression of Human NSAID Activated Gene 1 in Mice Leads to Altered Mammary Gland Differentiation and Impaired Lactation by April K. Binder (844405)

“…The WT dams had no detectable hNAG-1 in the milk. A decrease in non-esterified free fatty acids in the milk of hNAG-1 dams was observed. …”

Effects of 2-amino-4-phosphonobutyrat (40–80 µM APB) on neuronal activity of single units. by Katharina Spoida (308667)

“…<p>Responses of 3 units (mean and standard deviation of 10 measurements) to flashed and moving ON (A) and OFF (B) visual stimuli before (control) and after intravitreous drug injection (APB; intravitreous concentration 40–80 µM). …”

Our motoneuron model demonstrates that synaptic input noise does not account for signal dependent noise in synaptic input. by Akira Nagamori (4743981)

“…Note that this relationship is expressed as <i>SD</i> ∝ <i>mean</i>^0.5. B) Motoneuron discharge rates as a function of synaptic currents with (blue line) and without hysteresis (orange line) in motoneuron discharges. …”

The F2-isoprostane approach allows for analysis of FOXO transcription factor control of endogenous oxidative stress. by Christiaan F. Labuschagne (485155)

“…DLD-1 and DL-23 cells were incubated with 4-OHT to activate FOXO3a for 24 hours, before treatment with PQ for another 8 hours. 5-iPF2α-VI levels were analyzed and data are represented as mean fold increase ± S.E.M (*p < 0.05, *** p < 0.001).…”

Effect of antenatal class attendance on fear of childbirth and antenatal stress by Selda Yörük (15298001)

“…Fear of childbirth score were not significantly different between the intervention group and the control group. The mean APSI score of pregnant women in the intervention group was 22.32 ± 6.12 before the training and 21.79 ± 5.97 after the training. …”

Activation of the UPR can override the inhibition of NF-κB by IKK inhibitors in cancer cells with elevated IKK activity. by Arvin B. Tam (124164)

“…A reduction in P-IκBα and increase in total IκBα were seen corresponding to a decrease in IKK activity. …”

Effects of autophagic regulation on cardiac function. by Rong Xiao (130656)

“…Continuous K-H buffer perfusion without medication was used as a negative control. <b>A and B.</b> The left ventricular systolic pressure (LVSP) and the maximal rate of the rise/drop of left ventricular pressure (± dp/dt max) decreased in the hearts perfused with the autophagy activator rapamycin. …”

Table3_An implementation strategy package (video education, HIV self-testing, and co-location) improves PrEP implementation for pregnant women in antenatal care clinics in western... by Joseph Sila (16499841)

“…We observed no changes in service time (0.09-min decrease; p = 0.435) and a small increase in waiting time (0.33-min increase; p = 0.005). …”

Reconsolidation and extinction after different strengths of training. by Remus Osan (3639754)

“…Bars indicate freezing in vehicle (dark blue) and anisomycin (light blue) groups before (left set) and after (right set) reexposure with <i>t</i> = 4 (mean ± S.E.M. of 100 simulations). As occurs in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0023113#pone-0023113-g003" target="_blank">Figure 3C</a>, freezing is decreased by anisomycin administration, indicating reconsolidation blockade. …”

Expression of miR-202-3p and its target Sufu mRNA in CLL cells. by Mosavar Farahani (819379)

“…<p><b>(A)</b> HS-5 cells incubated with MEC-1 exosomes for 24 hrs show increased expression of miR-202-3p by RT-qPCR analysis. …”