Presentation_1_Utility of a Novel Three-Dimensional and Dynamic (3DD) Cell Culture System for PK/PD Studies: Evaluation of a Triple Combination Therapy at Overcoming Anti-HER2 Trea... by Anusha Ande (724831)

“…In the 3DD cell culture setting, sequential dosing of PAC then EVE+DAS showed a 5-fold increase in caspase-3 activity and 8.5-fold decrease in the total cell number compared to the control. …”

The Intensity of IUGR-Induced Transcriptome Deregulations Is Inversely Correlated with the Onset of Organ Function in a Rat Model by Daniel Vaiman (83223)

“…We show that (1) expressional alterations are apparently stronger in organs functioning late in foetal or postnatal life than in organs that are functioning early (2) hierarchical classification of the deregulations put together kidney and placenta in one cluster, liver, lungs and heart in another; (3) the epigenetic machinery is set up especially in the placenta, while its alterations are rather mild in other organs; (4) the genes appear deregulated in chromosome clusters; (5) the altered expression cascades varies from organ to organ, with noticeably a very significant modification of the complement and coagulation cascades in the kidney; (6) we found a significant increase in TF binding site for HNF4 proteins specifically for liver genes that are down-regulated in IUGR, suggesting that this decrease is achieved through the action of HNF transcription factors, that are themselves transcriptionnally induced in the liver by IUGR (x 1.84 fold). …”

IL‑6 Linkage to Exercise-Induced Shifts in Lipid-Related Metabolites: A Metabolomics-Based Analysis by David C. Nieman (322662)

“…Vastus lateralis muscle biopsy and blood samples were collected before and immediately after running and showed a 33.7 ± 4.2% decrease in muscle glycogen, 39.0 ± 8.8-, 2.4 ± 0.3-, and 1.4 ± 0.1-fold increases in plasma IL-6, IL-8, and MCP-1, respectively, and 95.0 ± 18.9 and 158 ± 20.6% increases in cortisol and epinephrine, respectively (all, <i>P</i> < 0.001). …”

In the absence of filament turnover, active networks cannot sustain continuous stress against a fixed boundary. by William M. McFadden (4692130)

“…<b>C)</b> Plots of total network stress and the average extensional (blue) and compressional (red) stress vs. time on individual filaments for the simulation shown in (A). Rapid buildup of extensional stress allows the network transiently to exert force on its boundary, but this force decays and this decay is closely associated with a decrease in extensional stress, reflecting the breakdown in network connectivity. …”

Time course of best-corrected visual acuity (BCVA) in all eyes. by Yasuyuki Sotani (20114144)

rTsSPc induced Caco-2 cell apoptosis. by Qi Qi Lu (17721401)

Abnormalities of AMPK Activation and Glucose Uptake in Cultured Skeletal Muscle Cells from Individuals with Chronic Fatigue Syndrome by Audrey E. Brown (677895)

“…The retention of these differences in cultured muscle cells from CFS subjects points to a genetic/epigenetic mechanism, and provides a system to identify novel therapeutic targets.…”

A thalamocortical cascade underlies perceptual switches. A) Thalamocortical ring architecture driven by input representing orthogonal gratings. B) Raster plots of L5_PT soma (blue) and matrix thalamus population (purple) during rivalry. C) Example single neuron spiking activity around a perceptual switch – dotted lines denote the crossing in the population averaged time series. D) Population averaged neuronal variables centred on a perceptual switch. E) Histogram of dominance durations, black line shows the fit of a Gamma distribution with parameters estimated via MLE (<i>α</i> = 4.85, <i>θ</i> = 0.56). F) Simulation confirming Levelt’s second proposition. Dashed line shows the dominance duration of the population receiving the decreasing external drive, solid line shows dominance duration of population receiving a fixed drive.... by Christopher J. Whyte (10221344)

“…Dashed line shows the dominance duration of the population receiving the decreasing external drive, solid line shows dominance duration of population receiving a fixed drive. …”

Virion-packaged A3G and infectivity of endogenous viruses produced from activated CD4+ T lymphocytes <i>ex vivo</i>. by MariaPia De Pasquale (471291)

“…<p>(<b>A</b>) Increased virion-packaged A3G protein was associated with decreased infectivity of endogenous viruses produced from activated CD4+ T lymphocytes. …”

Impact of DMSO on cumulus expansion of COCs during IVM. by Xuan Li (137217)

Overdispersion evaluation for GLMM with Poisson distribution. by Hugo Mendoza (11264458)

Richness and abundance of rodents. by Hugo Mendoza (11264458)

Kaplan-Meier survival curve. by Benzun Wei (21485639)

Identification of DEGs. by Benzun Wei (21485639)

KEGG pathway enrichment analyses of DEGs. by Benzun Wei (21485639)

Variables contribution plot. by Hugo Mendoza (11264458)

Anthropization variables. by Hugo Mendoza (11264458)

List of rodent species captured in the survey. by Hugo Mendoza (11264458)

GLMM’s prediction plot of rodent richness. by Hugo Mendoza (11264458)

Effects of Physical Activity Training in Patients with Alzheimer’s Dementia: Results of a Pilot RCT Study by Vjera A. Holthoff (351112)

“…</p><p>Methods</p><p>In an RCT thirty patients (aged 72.4±4.3 years) with AD (MMSE: 20.6±6.5 points) and their family caregivers were allocated to a home-based 12-week PA intervention program or the usual care group. …”