The NOD1 agonist iE induces NF-κB activation and apoptosis in cardiomyocytes and H9c2 cells. Effect of NOD1 ablation with siRNAs. by María Fernández-Velasco (105894)

“…(B) iE induces a decrease in cardiomyocyte viability in a dose-response form. …”

Infiltration of blood clots by cancer cells. by Stephanie Rossnagl (553093)

“…(F) Evaluation of cancer cell numbers when injected 5 minutes after clot induction showed a significant decrease in the number of cancer cells detected in the bone marrow at 1 hour after clot induction (p<0.05) but not at later time points (4, 24 and 48 hours after clot induction) (p = ns). n = 4–8 per time point.…”

Non-searching strategies in the Morris water maze test. by Glòria Arqué (51650)

“…<p>Floating behavior (A and B) was operationally defined as any period equal to or longer than 5 s, during which the average mouse swimming speed stayed below 3 cm.s⁻¹. …”

The effects of pretreatment with fingolimod-phosphate on BMECs in the presence of MS sera. by Hideaki Nishihara (545149)

“…Pretreatment with fingolimod-phosphate resulted in an increase in the claudin-5 protein levels (B) and TEER values (G) and a decrease in the VCAM-1 protein levels (F) in the BMECs, which were upregulated after exposure to the sera from all MS patients, including the RRMS-R, RRMS-S and SPMS patients, compared to that observed in the cells not pretreated with fingolimod-phosphate.…”

Effect of α-synuclein siRNA on α-synuclein protein in the monkey substantia nigra. by Alison L. McCormack (362670)

“…Data are expressed as percent of the control value in the right (untreated) substantia nigra and represent mean ± SEM. A significant decrease is caused by α-synuclein but not luciferase siRNA in the left (siRNA-infused) hemisphere. …”

FGF-9 Inhibits Infarct and Fibrosis in the Post-MI Diabetic Myocardium. by Dinender K. Singla (462521)

“…<b>G</b>: Histogram of quantitative infarct size analysis suggests a significant decrease in infarct size in the MI+FGF-9 group compared to the MI group. …”

Low fertility and postponement of first birth in Brazil by Adriana Miranda-Ribeiro (7453322)

“…Results show the persistence of regional differentials and point to (i) a scenario of postponement of first child in Brazil; and (ii) an increase in the proportion of childless women. …”

Effect of proprioceptive training on the untrained wrist tracking task. by Anna Vera Cuppone (3211041)

“…<p>Pre to posttest change in the use of haptic force feedback (HF) as a function of tracking error (TE). Each data point represents the coordinates of the respective group means. …”

LTPi is expressed presynaptically. by Joana Lourenço (594392)

“…(I) 2PSLM image (maximal intensity projection) of a layer 5 pyramidal neuron loaded with Alexa 594 (20 µM). …”

Mithramycin Exerts an Anti-Myeloma Effect and Displays Anti-Angiogenic Effects through Up-Regulation of Anti-Angiogenic Factors by Eléonore Otjacques (410361)

“…The administration of MTM to mice injected with 5TGM1 decreased 5TGM1 cell invasion into bone marrow and myeloma neovascularisation. …”

Compound 1294 interferes in host cell invasion. by Kayode K. Ojo (353587)

“…Cultures were maintained in the absence of 1294 (B), in the presence of 2.5 μM 1294 added 2 h post-invasion (C), and in the presence of 2.5 μM 1294 added already at the time point of invasion (D). …”

Frequency distributions of the <i>γ</i> values for the parameter sets that yield circadian oscillation. by Kazuhiro Maeda (182174)

“…<p>The frequency distributions of the quantitative balance between <i>X</i> and <i>Y</i> loops (<i>γ</i>) were simulated, while changing the kinetic symmetry (<i>ρ</i>): <i>ρ</i>≥99 (cross), <i>ρ</i> = 1 (circle), <i>ρ</i> = 0.1 (square), <i>ρ</i> = 0.01 (diamond). A decrease in <i>ρ</i> increases the kinetic symmetry. …”

Basal LDLR gene expression and activity is higher in PC-3 than LNCaP cells. by James Robert Krycer (104817)

“…Expression is represented as a fold change (relative to PC-3 cells), whereby a one-unit increase in ΔC_t results in a two-fold decrease in mRNA expression. …”

Proton Transfer and Structure-Specific Fluorescence in Hydrogen Bond-Rich Protein Structures by Dorothea Pinotsi (1305144)

“…The importance of proton transfer on the intrinsic fluorescence observed in protein fibrils is signified by large reductions in the fluorescence intensity upon either fully protonating, or deprotonating, the fibrils at pH = 0 or 14, respectively. Thus, our results point to the existence of a structure-specific fluorophore that does not require the presence of aromatic residues or multiple bond conjugation that characterize conventional fluorescent systems. …”

Increased S129-P-α-synuclein in acutely treated curcumin mice. by Kateri J. Spinelli (293686)

“…(n = 2 mice for DMSO treatment, n = 3 mice for curcumin treatment; each data point represents the average value for a 3μm z-stack, with 4–12 z-stacks analyzed per mouse; pink arrows indicate colocalized synapses, white arrows indicate lack of colocalization; *p<0.05,**p<0.01,***p<0.001, Scale bar = 5 μm).…”

Proton Transfer and Structure-Specific Fluorescence in Hydrogen Bond-Rich Protein Structures by Dorothea Pinotsi (1305144)

“…The importance of proton transfer on the intrinsic fluorescence observed in protein fibrils is signified by large reductions in the fluorescence intensity upon either fully protonating, or deprotonating, the fibrils at pH = 0 or 14, respectively. Thus, our results point to the existence of a structure-specific fluorophore that does not require the presence of aromatic residues or multiple bond conjugation that characterize conventional fluorescent systems. …”

Proton Transfer and Structure-Specific Fluorescence in Hydrogen Bond-Rich Protein Structures by Dorothea Pinotsi (1305144)

“…The importance of proton transfer on the intrinsic fluorescence observed in protein fibrils is signified by large reductions in the fluorescence intensity upon either fully protonating, or deprotonating, the fibrils at pH = 0 or 14, respectively. Thus, our results point to the existence of a structure-specific fluorophore that does not require the presence of aromatic residues or multiple bond conjugation that characterize conventional fluorescent systems. …”

Flux changes and osmotic stress kinetic order distribution in osmotic conditions (0.3 M). by Guido Santos (171018)

“…<p><b>A.</b> Mean flux changes in logarithmic scale of (the mean of) the selected solutions. …”

Stability of beta-titanium T-loop springs preactivated by gradual curvature by Sergei Godeiro Fernandes Rabelo Caldas (4791744)

“…Results: The horizontal forces decreased gradually among the groups (p< 0.001) and the moments showed a significant and slow decrease over time among the groups (p< 0.001). …”

Cardiovascular and respiratory effects of lumbosacral epidural bupivacaine in isoflurane-anesthetized dogs: The effects of two volumes of 0.25% solution by Raquel Sartori Gonçalves Dias (5117654)

“…Mean arterial pressure decreased significantly from 15 to 90 minutes after the administration of BUP02 and from 5 to 60 minutes in BUP04, with lower values in BUP04 than in BUP02 lasting up to 30 minutes after bupivacaine administration. …”