Enabling <i>C</i>. <i>glabrata</i> to make or use HMP allows for synthesis of thiamine and growth in starvation conditions. by Christine L. Iosue (2576281)

“…<p>(A) Adding back <i>THI5</i> in the genome or on a plasmid restores growth to <i>C</i>. …”

OG33 and OG35 cells are recalcitrant to differentiation. by Patrick M. Long (487632)

“…<p>OG33 (A) and OG35 (B-D) cells were induced to differentiate over 6 days <i>in </i><i>vitro</i> via activation of adenylyl cyclase (1 mM dibutyryl cAMP or 10 μM forskolin) or inhibition of MEK1/2 (1 μM PD035901), ErbB2 (1 μM PD174285), PI3K (5 μM and 10 μM LY294002), or mTOR (10 nM and 20 nM rapamycin [RAP]) signaling. …”

Sulindac Compounds Facilitate the Cytotoxicity of β-Lapachone by Up-Regulation of NAD(P)H Quinone Oxidoreductase in Human Lung Cancer Cells by Hsiu-Ni Kung (138467)

“…In the second part, we found that the FDA-approved non-steroidal anti-inflammatory drug sulindac and its metabolites, sulindac sulfide and sulindac sulfone, increased NQO1 expression and activity in the lung adenocarcinoma cell lines CL1-1 and CL1-5, which have lower NQO1 levels and lower sensitivity to β-lapachone treatment than the A549 cell lines, and that inhibition of NQO1 by either dicoumarol treatment or NQO1 siRNA knockdown inhibited this sulindac-induced increase in β-lapachone cytotoxicity. …”

Figure S1 - Tau Reduction Does Not Prevent Motor Deficits in Two Mouse Models of Parkinson's Disease by Meaghan Morris (191386)

“…Mice (n = 7-12 per genotype and treatment) received a unilateral striatal injection of 6-OHDA or vehicle at 2.6–5.8 months of age and were tested behaviorally beginning 24 days later. …”

Rapid Myoglobin Aggregation through Glucosamine-Induced α-Dicarbonyl Formation by Yuliya Hrynets (800300)

“…Already at 0.5 days, tertiary structural changes of Mb-GlcN conjugate were observed by altered tryptophan fluorescence. …”

Polychlorinated Naphthalenes across the Great Lakes: Lake Trout and Walleye Concentrations, Trends, and TEQ Assessment2004–2018 by James J. Pagano (2043490)

“…Based on the average number of chlorines per naphthalene, we determined that the overall lake trout and walleye PCN congener distribution has significantly shifted to a lower-chlorinated composition in the Great Lakes (5.33 to 4.48 Cl/CN) and has resulted in a substantial 59.1% reduction of the overall total PCN TEQ burden. …”

An Atypical Unfolded Protein Response in Heat Shocked Cells by Lonneke Heldens (210311)

“…</p> <h3>Results</h3><p>In heat stressed HEK293 cells synthesis of the canonical UPR transcription factors XBP1s and ATF4 was detected as well as HSF1 independent activation of the promoters of the ER resident chaperones HSPA5 (BiP) and DNAJB9 (ERdj4). However, the heat stress activation of the DNAJB9 promoter, a XBP1s target, was not blocked in cells expressing a dominant negative IRE1α mutant, and thus did not require XBP1s. …”

Table1_Impact of weirs in altering benthic macroinvertebrate assemblages and composition structure in the Luvuvhu River Catchment, South Africa.docx by Humbulani E. Munzhelele (17990026)

“…The aim of this study was to examine the impact of six weirs on aquatic macroinvertebrate assemblages and composition across five streams. A total of six sampling surveys on macroinvertebrates and physico-chemical parameters were conducted upstream and downstream of six weirs in 12 months between June 2021 and June 2022. …”

DIGESTIBLE VALINE REQUIREMENTS IN LOW-PROTEIN DIETS FOR BROILERS CHICKS by GR Nascimento (12803021)

“…<div><p>ABSTRACT Three experiments were carried out to evaluate the levels of digestible valine in diets with reduced crude protein on the performance, carcass yield and muscle fiber diameter of male broilers during the pre-starter (1 to 8 d of age), starter (9 to 21 d of age) and grower phases (21 to 42 d of age). A total of 1,080 chickens in the pre-starter phase, 900 in the starter phase and 864 in the grower phase were distributed in a completely randomized design with six treatments, consisting of a control positive diet (C+) and diets with 2 percentage points (p.p.) reduction of crude protein level and five graded levels of digestible valine (Val), with six replicates of 30, 25 and 24 birds per experimental unit, respectively. …”

Supplementary file 1_Herring oil rich in long-chain monounsaturated fatty acid (C22: 1n-11) lowers plasma lipids and modulates fatty acid composition, oxidation, and inflammation i... by Camilla H. Nundal (22319320)

Table_1_Indomethacin Increases the Efficacy of Oxygen Utilization of Colonic Mitochondria and Uncouples Hepatic Mitochondria in Tissue Homogenates From Healthy Rats.DOCX by Anna Herminghaus (6187586)

“…ADP/O ratio increased in complex I at concentrations of 1,000 and 3,000 μM (Indo 1,000 μM: 113.9/158.9/166.9%^*; Indo 3,000 μM: 151.5/183.0/361.5%^*) and in complex II at concentrations of 179 and 3,000 μM vs. control (179 μM: 111.3/73.1/74.9%^*; 3,000 μM: 132.4/175.0/339.4%^*). …”

Table_1_Properties and Roles of γδT Cells in Plasmodium yoelii nigeriensis NSM Infected C57BL/6 Mice.xlsx by Hongyan Xie (264700)

“…Background<p>Many kinds of immune cells are involved in malaria infection. γδT cells represent a special type of immune cell between natural and adaptive immune cells that play critical roles in anti-parasite infection.…”

Image_2_Properties and Roles of γδT Cells in Plasmodium yoelii nigeriensis NSM Infected C57BL/6 Mice.jpeg by Hongyan Xie (264700)

“…Background<p>Many kinds of immune cells are involved in malaria infection. γδT cells represent a special type of immune cell between natural and adaptive immune cells that play critical roles in anti-parasite infection.…”

Patterns and Possible Roles of LINE-1 Methylation Changes in Smoke-Exposed Epithelia by Siriporn Wangsri (134838)

“…<div><p>Tobacco smoking and reduced methylation of long interspersed element-1 (LINE-1) are crucial in oral carcinogenesis. 5′UTR of human LINE-1 sequence contains several CpG dinucleotides which are methylated in various proportions (0–100%). …”

Image_1_Properties and Roles of γδT Cells in Plasmodium yoelii nigeriensis NSM Infected C57BL/6 Mice.jpeg by Hongyan Xie (264700)

“…Background<p>Many kinds of immune cells are involved in malaria infection. γδT cells represent a special type of immune cell between natural and adaptive immune cells that play critical roles in anti-parasite infection.…”

Functional neurologic outcomes are superior in the IA MSC_24 h group. by Dileep R. Yavagal (453696)

“…The ND score of the 1×10⁵ group progressively decreased over time and at 28 days was significantly lower than the other groups. …”

The variation of microcrustaceans diversity downstream of small reservoirs is influenced by litoranean taxa by Milena Sartori (10376949)

“…There were higher values of ecological attributes in lentic environments, but there were significant increases in richness and diversity in the last points of the stretches of the stream, while the abundance decreased gradually downstream. …”

Molecular Design of Anionic Phthalocyanines with π–π Stacking Columnar Arrangement. Crystal Structures, Optical, and Magnetic Properties of Salts with the Iron(I) Hexadecachloropht... by Dmitri V. Konarev (1405348)

“…Different shift of phthalocyanines at the same interplanar distances of 3.33–3.38 Å provides essentially shorter Fe···Fe distances in <b>3</b> (3.62–3.84 Å) than those in <b>1</b> and <b>2</b> (5.07–5.45 Å). …”

Molecular Design of Anionic Phthalocyanines with π–π Stacking Columnar Arrangement. Crystal Structures, Optical, and Magnetic Properties of Salts with the Iron(I) Hexadecachloropht... by Dmitri V. Konarev (1405348)

“…Different shift of phthalocyanines at the same interplanar distances of 3.33–3.38 Å provides essentially shorter Fe···Fe distances in <b>3</b> (3.62–3.84 Å) than those in <b>1</b> and <b>2</b> (5.07–5.45 Å). …”

Ubiquitin carboxyl-terminal esterase L1 (UCHL1) is associated with stem-like cancer cell functions in pediatric high-grade glioma by Patricia C. Sanchez-Diaz (403746)

“…UCHL1 depletion in SF188 and SJ-GBM2 glioma cells was associated with decreased cell proliferation and invasion, along with a reduced ability to grow in soft agar and to form spheres (i.e. self-renewal measure). …”