Protein disulfide isomerases (PDIs) negatively regulate ebolavirus structural glycoprotein expression in the endoplasmic reticulum (ER) via the autophagy-lysosomal pathway by Bin Wang (30851)

“…</p> <p><b>Abbreviations:</b> 3-MA: 3-methyladenine; 4-PBA: 4-phenylbutyrate; ACTB: β-actin; ATF: activating transcription factor; ATG: autophagy-related; BafA1: bafilomycin A₁; BDBV: <i>Bundibugyo</i> ebolavirus; CALR: calreticulin; CANX: calnexin; CHX: cycloheximide; CMA: chaperone-mediated autophagy; ConA: concanamycin A; CRISPR: clusters of regularly interspaced short palindromic repeats; Cas9: CRISPR-associated protein 9; dsRNA: double-stranded RNA; EBOV: <i>Zaire</i> ebolavirus; EDEM: ER degradation enhancing alpha-mannosidase like protein; EIF2AK3/PERK: eukaryotic translation initiation factor 2 alpha kinase 3; Env: envelope glycoprotein; ER: endoplasmic reticulum; ERAD: ER-associated protein degradation; ERN1/IRE1: endoplasmic reticulum to nucleus signaling 1; GP: glycoprotein; HA: hemagglutinin; HDAC6: histone deacetylase 6; HMM: high-molecular-mass; HIV-1: human immunodeficiency virus type 1; HSPA5/BiP: heat shock protein family A (Hsp70) member 5; IAV: influenza A virus; IP: immunoprecipitation; KIF: kifenesine; Lac: lactacystin; LAMP: lysosomal associated membrane protein; MAN1B1/ERManI: mannosidase alpha class 1B member 1; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MARV: Marburg virus; MLD: mucin-like domain; NHK/SERPINA1: alpha1-antitrypsin variant null (Hong Kong); NTZ: nitazoxanide; PDI: protein disulfide isomerase; RAVV: Ravn virus; RESTV: Reston ebolavirus; SARS-CoV: severe acute respiratory syndrome coronavirus; SBOV: <i>Sudan</i> ebolavirus; sGP: soluble GP; SQSTM1/p62: sequestosome 1; ssGP: small soluble GP; TAFV: Taï Forest ebolavirus; TIZ: tizoxanide; TGN: thapsigargin; TLD: TXN (thioredoxin)-like domain; Ub: ubiquitin; UPR: unfolded protein response; VLP: virus-like particle; VSV: vesicular stomatitis virus; WB: Western blotting; WT: wild-type; XBP1: X-box binding protein 1.…”

Passive-transfer of monoclonal antibodies (mab) and protection from H1N1 challenge. by Dustin M. McCraw (16892354)

“…<p>(A) Survival curves for mice that were intranasally challenged with H1N1 virus 24 hours after intraperitoneally (IP) transfer of mAb-11, mAb-49, mAb-63, mAb-67 and mAb-85 at doses of 17.5 mg/kg. …”

Data_Sheet_2_The Consequences of Glacier Retreat Are Uneven Between Plant Species.PDF by Gianalberto Losapio (3739021)

“…This pattern suggests a role of facilitation for enhancing plant diversity in recently ice-free terrains and of competition for decreasing species persistence in late stages. …”

The energy efficiency of action potential generation increases as temperature increases. by Yuguo Yu (172221)

“…For both the HH simulation of the squid giant axon (DC injection 20×10⁻² pA/µm²), and for a model of cortical pyramidal cell axons (DC injection 0.5×10⁻² pA/µm²), increasing temperature strongly decreases the excess Na⁺ entry during action potential generation. …”

DataSheet_1_Complex Above- and Below-Ground Growth Responses of Two Urban Tree Species Following Root, Stem, and Foliage Damage—An Experimental Approach.docx by Valentina Vitali (7399679)

“…For Celtis, root injury was the treatment having the most impact, decreasing both root and stem growth consistently throughout the 5 years following treatments, whereas defoliation decreased growth only in the first 2 years. …”

Supplementary materials for PhD thesis “The Origin of Basaltic Lava Flow Textures” by Marie-Noëlle Guilbaud (2843387)

“…It is estimated that fluid lava was transported from the vent to the most distal active front, 60 km from the vent, with cooling rates of < 0.5°C/km. Young lava flow-fields in the Reykjanes Peninsula (Iceland), and some flows from the flood basalts of the Columbia River Province (USA), have surface and internal structures intermediate between rubbly pāhoehoe and 'a'ā. …”

Data_Sheet_1_The Consequences of Glacier Retreat Are Uneven Between Plant Species.PDF by Gianalberto Losapio (3739021)

“…This pattern suggests a role of facilitation for enhancing plant diversity in recently ice-free terrains and of competition for decreasing species persistence in late stages. …”

image_2_Type I and III Interferon Productions Are Impaired in X-Linked Agammaglobulinemia Patients Toward Poliovirus but Not Influenza Virus.jpeg by Anderson Dik Wai Luk (5618996)

“…Background<p>X-linked agammaglobulinemia (XLA) is a primary immunodeficiency caused by Bruton’s tyrosine kinase (BTK) mutation. …”

image_1_Type I and III Interferon Productions Are Impaired in X-Linked Agammaglobulinemia Patients Toward Poliovirus but Not Influenza Virus.jpeg by Anderson Dik Wai Luk (5618996)

“…Background<p>X-linked agammaglobulinemia (XLA) is a primary immunodeficiency caused by Bruton’s tyrosine kinase (BTK) mutation. …”

image_3_Type I and III Interferon Productions Are Impaired in X-Linked Agammaglobulinemia Patients Toward Poliovirus but Not Influenza Virus.jpeg by Anderson Dik Wai Luk (5618996)

“…Background<p>X-linked agammaglobulinemia (XLA) is a primary immunodeficiency caused by Bruton’s tyrosine kinase (BTK) mutation. …”

Table_1_Anti-Migratory Effect of Dipotassium Glycyrrhizinate on Glioblastoma Cell Lines: Microarray Data for the Identification of Key MicroRNA Signatures.docx by Gabriel Alves Bonafé (6740750)

“…In addition, DPG treatment led to a 100% reduction in sphere formation. The qPCR results in U251 and U138MG cells showed that DPG increased miR-4443 (2.44 vs. 1.11, p-value = 0.11; 8.27 vs. 1.25, p-value = 0.04) and miR-3620 expression (1.66 vs. 1.00, p-value = 0.03; 8.47 vs. 1.01, p-value = 0.03) and decreased CD209 (0.44 vs. 1.10, p-value = 0.03; 0.49 vs. 1.07, p-value = 0.04) and TNC (0.20 vs. 1.03, p-value = 0.001; 0.39 vs. 1.06, p-value = 0.01) mRNA levels compared to controls. …”

PINK1-deficiency facilitates mitochondrial iron accumulation and colon tumorigenesis by Mariella Arcos (17617599)

“…</p> <p><b>Abbreviation</b>: ANOVA: analysis of variance; APC: adenomatous polyposis coli; cAMP: cyclic adenosine monophosphate; CDX2: caudal type homeobox 2; CGAS: cyclic GMP-AMP synthase; CRC: colorectal cancer; DNA: deoxyribonucleic acid; DFP: deferiprone; DMEM: Dulbecco’s modified Eagle medium; DSS: dextran sodium sulfate; ERT2-Cre: Cre recombinase fused to a triple mutant form of the human estrogen receptor; EV: empty vector; GLB: glybenclamide/glyburide; H&E: hematoxylin and eosin; ICP-MS: inductively coupled plasma mass spectrometer; IL1B: interleukin 1 beta; kDa: kilodalton; MCU: mitochondrial calcium uniporter; MKI67: marker of proliferation Ki-67; mRNA: messenger ribonucleic acid; MTT: 3-(4,5-dimethylthiazol-2-Yl)-2,5-diphenyltetrazolium bromide; NLRP3: NLR family pyrin domain containing 3; OE: overexpression; PBS: phosphate-buffered saline; p-CREB: phosphorylated cAMP responsive element binding protein; PINK1: PTEN induced kinase 1; p-PRKAA/AMPK: phosphorylated protein kinase AMP-activated catalytic subunit alpha; qPCR: qualitative polymerase chain reaction; RNA-seq: ribonucleic acid sequencing; ROS: reactive oxygen species; sg: single guide; sh: short hairpin; SLC25A28: solute carrier family 25 member 28; SLC25A37/MFRN: solute carrier family 25 member 37; STING1: stimulator of interferon response cGAMP interactor 1; TP53/p53: tumor protein p53; TUBA: tubulin alpha; µL: microliter; µm: micrometer; µM: micromolar; mm: millimeter.…”

Image1_Neuroprotective effects of total phenolics from Hemerocallis citrina Baroni leaves through the PI3K/AKT pathway.pdf by Yanjun Jia (10142216)

“…<p>Neurological injury, as a major pathogenic mechanism in depression, holds significant importance in the research and development of antidepressant drugs. …”

P4HA3 deficiency increased sensitization to immune checkpoint inhibitors and P4HA3 could predict the clinical therapeutic effect of PD-1 inhibitor (Camrelizumab). by Hong Yan Huang (20135965)

“…<p>(A) P4HA3 deficiency inhibited migration and invasion abilities of MDA-MB-231, HCT116 and A549 cell lines by transwell assay. …”

Image_2_Anti-Migratory Effect of Dipotassium Glycyrrhizinate on Glioblastoma Cell Lines: Microarray Data for the Identification of Key MicroRNA Signatures.jpeg by Gabriel Alves Bonafé (6740750)

“…In addition, DPG treatment led to a 100% reduction in sphere formation. The qPCR results in U251 and U138MG cells showed that DPG increased miR-4443 (2.44 vs. 1.11, p-value = 0.11; 8.27 vs. 1.25, p-value = 0.04) and miR-3620 expression (1.66 vs. 1.00, p-value = 0.03; 8.47 vs. 1.01, p-value = 0.03) and decreased CD209 (0.44 vs. 1.10, p-value = 0.03; 0.49 vs. 1.07, p-value = 0.04) and TNC (0.20 vs. 1.03, p-value = 0.001; 0.39 vs. 1.06, p-value = 0.01) mRNA levels compared to controls. …”

Table1_Neuroprotective effects of total phenolics from Hemerocallis citrina Baroni leaves through the PI3K/AKT pathway.docx by Yanjun Jia (10142216)

“…<p>Neurological injury, as a major pathogenic mechanism in depression, holds significant importance in the research and development of antidepressant drugs. …”

Cadherin-16 promotes startle thresholds by limiting Stanniocalcin 1l expression and promoting Papp-aa function. by Susannah S. Schloss (21238775)

“…<p><b>(A)</b><i>stc1l</i> crispants (<i>n</i> = 18) have a decreased response to acoustic stimuli compared to control guide-injected larvae (<i>n</i> = 18) *<i>p</i> = 0.0475, two-way ANOVA with Šídák’s multiple comparisons test. …”

Table2_Neuroprotective effects of total phenolics from Hemerocallis citrina Baroni leaves through the PI3K/AKT pathway.docx by Yanjun Jia (10142216)

“…<p>Neurological injury, as a major pathogenic mechanism in depression, holds significant importance in the research and development of antidepressant drugs. …”

Image_1_Anti-Migratory Effect of Dipotassium Glycyrrhizinate on Glioblastoma Cell Lines: Microarray Data for the Identification of Key MicroRNA Signatures.jpeg by Gabriel Alves Bonafé (6740750)

“…In addition, DPG treatment led to a 100% reduction in sphere formation. The qPCR results in U251 and U138MG cells showed that DPG increased miR-4443 (2.44 vs. 1.11, p-value = 0.11; 8.27 vs. 1.25, p-value = 0.04) and miR-3620 expression (1.66 vs. 1.00, p-value = 0.03; 8.47 vs. 1.01, p-value = 0.03) and decreased CD209 (0.44 vs. 1.10, p-value = 0.03; 0.49 vs. 1.07, p-value = 0.04) and TNC (0.20 vs. 1.03, p-value = 0.001; 0.39 vs. 1.06, p-value = 0.01) mRNA levels compared to controls. …”

MSCs inhibit lung edema and inflammatory cells in HS rats. by Shibani Pati (208746)

“…Five sections were analyzed per animal (n = 5) and 8–10 high power fields were counted for fluorescent positive (CD68+) cells. …”