Video 1_Effect of Fangxia-Dihuang Decoction on doxorubicin-induced cognitive impairment in breast cancer animal model.mp4 by Xuan Wang (55634)

“…</p>Methods<p>Build 4T1 breast cancer xenograft tumor model in Balb/c mice, intraperitoneal injection of DOX (5mg/kg) once a week, build the model of DOX induced chemotherapy related cognitive impairment (CRCI), and the administration lasted for three weeks. …”

Image6_Arbuscular mycorrhizal fungi alleviate Mn phytotoxicity by altering Mn subcellular distribution and chemical forms in Lespedeza davidii.tif by Gao Pan (12510447)

“…</p>Methods<p>In this study, Lespedeza davidii inoculated with or without AMF (Glomus mosseae) under different Mn concentrations (0 mmol/L, 1 mmol/L, 5 mmol/L, 10 mmol/L, and 20 mmol/L) was cultivated via a pot experiment, and plant biomass, physiological and biochemical characteristics, manganese absorption, subcellular distribution, and chemical forms of Mn were examined.…”

Image 1_Efficacy and safety of leuprorelin (Boennuokang®) plus endocrine therapy in premenopausal women with HR+/HER2− breast cancer.tif by Xiuping Wu (527012)

“…During 24 months, the follicle-stimulating hormone level was decreased from 7.7 to 4.8 mIU/mL, and the luteinizing hormone level was decreased from 7.9 to 0.2 mIU/mL (both P < 0.001). …”

Image 2_Efficacy and safety of leuprorelin (Boennuokang®) plus endocrine therapy in premenopausal women with HR+/HER2− breast cancer.tif by Xiuping Wu (527012)

“…During 24 months, the follicle-stimulating hormone level was decreased from 7.7 to 4.8 mIU/mL, and the luteinizing hormone level was decreased from 7.9 to 0.2 mIU/mL (both P < 0.001). …”

Chrysophanol inhibits the osteoglycin/mTOR and activats NF2 signaling pathways to reduce viability and proliferation of malignant meningioma cells by Jiapeng Wang (1405873)

“…Chrysophanol significantly reduced HBL-52 cell viability, based on reduced colony formation, and proliferation, based on low levels of bromodeoxyuridine incorporation. Annexin V/propidium iodide staining revealed a 30% increase in apoptotic cells at 90 μM chrysophanol (33.7% vs 3.3% in control cultures). …”

Relationship of body mass index and waist circumference with clinical outcomes following percutaneous coronary intervention by Yonggu Lee (436856)

“…Patients were evenly divided into 4 groups according to BMI (Q1_BMI, Q2_BMI, Q3_BMI and Q4_BMI) and WC (Q1_WC, Q2_WC, Q3_WC and Q4_WC).</p><p>Results</p><p>A total of 1,421 patients were observed for 5 years. …”

CEP164 regulates cell cycle progression and proliferation. by Gisela G. Slaats (648603)

“…<p>(A) RPE-FUCCI cells and their daughter cells were tracked by live cell imaging for 72 hours (hr) after transfection. …”

Key barriers and enablers associated with uptake and continuation of oral pre-exposure prophylaxis (PrEP) in the public sector in Zimbabwe: Qualitative perspectives of general popu... by Makaita M. Gombe (8294007)

“…Clients who opted for PrEP preferred it to other forms of HIV prevention. SDCs reported decreased condom use after PrEP initiation and in some cases were using PrEP while trying to conceive a child. …”

Data Sheet 1_Modeling lymphocyte subset dynamics after ublituximab therapy in patients with multiple sclerosis: an Italian prospective study.pdf by Aurora Zanghì (9202094)

“…To identify determinants of early residual depletion, linear regression models were built.</p>Results<p>A total cohort of 16 patients was enrolled, with a median age of 47 (Q1–Q3 41–58), 69% men, median EDSS of 4.5, and median body mass index (BMI) of 26.9 kg/m². …”

Antimicrobial activity of RP-1 peptide conjugate with ferrocene group by Natalia C. S. Costa (8626206)

“…In comparison with amphotericin B, a second-line drug approved for leishmaniasis treatment, (IC₅₀ = 0.63 μmol L^-1), Fc-RP1 was more active and showed a 2.5-fold higher selectivity index. …”

Table_1_Granulocyte Colony-Stimulating Factor Accelerates the Recovery of Hepatitis B Virus-Related Acute-on-Chronic Liver Failure by Promoting M2-Like Transition of Monocytes.docx by Jingjing Tong (2572018)

“…A total of 111 patients with HBV-ACLF were prospectively randomized into the G-CSF group (5 μg/kg G-CSF every day for 6 days, then every other day until day 18) or the control group (standard therapy). …”

Relationship between the normalized difference vegetation index and leaf area in vineyards by Amanda Heemann Junges (4627513)

“…The NDVI evolution pattern is described by a quadratic regression equation: the index increases rapidly at first (September to November), followed by a relative stabilization (December to February), and decreases in the final stage (March to May). …”

Relationship between the normalized difference vegetation index and leaf area in vineyards by Amanda Heemann Junges (4627513)

“…The NDVI evolution pattern is described by a quadratic regression equation: the index increases rapidly at first (September to November), followed by a relative stabilization (December to February), and decreases in the final stage (March to May). …”

Physical-hydraulic soil attributes in an integrated production system with different “paricá” forest component arrangements by Wellington de Azambuja Magalhães (5254961)

“…Soil was collected from five sampling points considering the distances from the tree lines. …”

Simulated currents of the voltage-gated potassium channels SHL-1, KVS-1, SHK-1, IRK-1/3, KQT-3, EGL-36 and EGL-2. by Martina Nicoletti (6900464)

“…The current inactivates exponentially with a time constant that is a decreasing function of voltage ( at 0 mV, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0218738#pone.0218738.s003" target="_blank">S1 Fig</a>). …”

Functional Characterization of FLT3 Receptor Signaling Deregulation in Acute Myeloid Leukemia by Single Cell Network Profiling (SCNP) by David B. Rosen (104278)

“…Specifically, increased basal p-Stat5 levels, decreased FLT3L induced activation of the PI3K and Ras/Raf/Erk pathways, decreased IL-27 induced activation of the Jak/Stat pathway, and heightened apoptotic responses to agents inducing DNA damage were observed in FLT3-ITD AML samples. …”

Image_1_Exercise attenuates high-fat diet-induced PVAT dysfunction through improved inflammatory response and BMP4-regulated adipose tissue browning.pdf by Xiaojie Liu (290772)

“…Exercise training promoted transcriptional activation of BMP4 and associated signaling molecules (p38/MAPK, ATF2, PGC1α, and Smad5) that are involved in browning of adipose tissue. …”

Kmo inhibition or depletion impairs lysosome acidification in both exposed and infected macrophages. by Emily R. Goering (22486572)

“…<p>(<b>A</b>) Kmo inhibition with Ro61–8048 decreased maximum Lysotracker fluorescence in both infected and exposed bystander macrophages, which was restored upon treatment with exogenous 3-HK. …”

Table_1_Effects of Immobilized Antimicrobial Peptides on Growth Performance, Serum Biochemical Index, Inflammatory Factors, Intestinal Morphology, and Microbial Community in Weanin... by Nian Liu (29935)

“…The results showed the following: (1) compared with the CON group, the average daily gain in the whole experimental time (p < 0.05) was significantly increased, and the diarrhea rate of weaning piglets was decreased (p < 0.01) in the IAMPs group; (2) compared with the CON group, the concentrations of serum IgM and superoxide dismutase (SOD) in the IAMPs group were significantly higher than the CON and AB groups (p < 0.01); (3) compared with CON group, the concentrations of serum interleukin (IL)-10 and transforming growth factor (TGF-β) were significantly increased (p < 0.05), and the concentration of IL-12 was significantly decreased (p < 0.05) in the IAMPs group; (4) compared with CON group, the concentrations of serum endotoxin and D-lactate of piglets were significantly reduced (p < 0.05), and the relative expression of ZO-1 and occludin in the jejunum of piglets were significantly increased (p < 0.05) in the IAMPs group; (5) compared with the CON group, the villus height of the duodenum and jejunum of weaning piglets in IAMPs and AB groups was significantly increased (p < 0.05); and (6) compared with CON group, the relative abundance of Escherichia–Shigella in the colon and cecal digesta was decreased. …”

Table_1_Modulation of Gut Microbiota by Low Methoxyl Pectin Attenuates Type 1 Diabetes in Non-obese Diabetic Mice.pdf by Chengfei Wu (5106272)

“…The current study aimed to investigate the efficacy of supplementing a novel specific low-methoxyl pectin (LMP) dietary fiber in preventing T1D development. …”