Antiparallel Coupling between a 4f System and a Photoexcited Cyclic π System in a Dysprosium(III) Monoporphyrinato Complex by Anas Santria (4353268)

“…The MCD A-term patterns of the compound show a negative increment in the intensity by decreasing temperature and nonproportionality to the magnetic field. …”

A single mutation in the envelope protein modulates flavivirus antigenicity, stability, and pathogenesis by Leslie Goo (3752755)

“…Introduction of a mutation at the analogous residue of dengue virus (DENV), but not Zika virus (ZIKV), E protein also increased accessibility of the cryptic fusion loop epitope and decreased virus stability in solution, suggesting that this residue modulates the structural ensembles sampled by distinct flaviviruses at equilibrium in a context dependent manner. …”

A Mechanism for the Inhibition of DNA-PK-Mediated DNA Sensing by a Virus by Nicholas E. Peters (466366)

“…Recently, DNA-dependent protein kinase (DNA-PK), a heterotrimeric complex consisting of the Ku70/Ku80 heterodimer and the catalytic subunit DNA-PKcs was identified as a cytoplasmic PRR for DNA that is important for the innate immune response to intracellular DNA and DNA virus infection. …”

Synthesis and Apoptotic Effects of DNMT Inhibition Targeted Novel Hybrid Molecules Bearing Thiadiazole and Clopidogrel for Cancer Treatment by Sevgi Karakuş (9731958)

“…DNMT enzyme activity was decreased in these compounds’ treated cells. Cyclohexyl ring-bearing compound <b>4d</b>, which showed the highest activity against U87 cells, was the most potent inhibitor of DNMT with an IC₅₀ value of 5.78 ± 1.07 µM compared to paclitaxel (82.05 ± 4.67 µM). …”

G2019S LRRK2 modulates Tf recycling in iPSC-derived human microglia. by Adamantios Mamais (302600)

“…The percentage of Tf vesicles proximal to the nucleus was significantly decreased with LPS treatment in WT but not in G2019S LRRK2 cells (E, F) (E: bin at 0.5 μm, two-tailed Student <i>t</i> test; Mann–Whitney <i>U</i> post hoc; **<i>P</i> = 0.0022; F: bin at 0.5 μm, two-tailed Student <i>t</i> test; Mann–Whitney <i>U</i> post hoc; NS). …”

Image 1_Virus-specific Dicer-substrate siRNA swarms inhibit SARS-CoV-2 infection in TMPRSS2-expressing Vero E6 cells.tif by Miao Jiang (442328)

“…Therefore, novel therapeutic approaches against SARS-CoV-2 infection are still urgently needed. As a positive-sense single-stranded RNA virus, SARS-CoV-2 is highly susceptible to RNA interference (RNAi). …”

Image 2_Virus-specific Dicer-substrate siRNA swarms inhibit SARS-CoV-2 infection in TMPRSS2-expressing Vero E6 cells.tif by Miao Jiang (442328)

“…Therefore, novel therapeutic approaches against SARS-CoV-2 infection are still urgently needed. As a positive-sense single-stranded RNA virus, SARS-CoV-2 is highly susceptible to RNA interference (RNAi). …”

Image 3_Virus-specific Dicer-substrate siRNA swarms inhibit SARS-CoV-2 infection in TMPRSS2-expressing Vero E6 cells.tif by Miao Jiang (442328)

“…Therefore, novel therapeutic approaches against SARS-CoV-2 infection are still urgently needed. As a positive-sense single-stranded RNA virus, SARS-CoV-2 is highly susceptible to RNA interference (RNAi). …”

Image_5_Early Growth Response Gene-2 Is Essential for M1 and M2 Macrophage Activation and Plasticity by Modulation of the Transcription Factor CEBPβ.jpg by Tatyana Veremeyko (394702)

Image_5_Early Growth Response Gene-2 Is Essential for M1 and M2 Macrophage Activation and Plasticity by Modulation of the Transcription Factor CEBPβ.jpg by Tatyana Veremeyko (394702)

Image 5_Silicon enhanced phosphorus uptake in rice under dry cultivation through root organic acid secretion and energy distribution in low phosphorus conditions.tif by Hao Jiang (95017)

“…On the other hand, the addition of silicon alleviated phosphorus limitations by reducing ATP consumption in roots through a decrease in ATPase and P-ATPase content. This also minimized excessive NSC transport to roots, thereby promoting shoot growth by downregulating SUT1, SWEET11, SUS2, and CIN2. …”

Image 5_Trends and cross-country inequality in the global burden of nutritional deficiencies in children, with projections to 2035: results from the Global Burden of Disease study... by Shihao Zhuang (9931763)

Table5_Thermodynamic Properties of Fe-Bearing Wadsleyite and Determination of the Olivine-Wadsleyite Phase Transition Boundary in (Mg,Fe)2SiO4 System.XLSX by Chang Su (170990)

AprA, CfaD, and QkgA are required for inhibition of proliferation by BzpN. by Jonathan E. Phillips (214646)

“…Expression of BzpN-GFP in wild-type cells resulted in a significant decrease in cell density on days 5 through 8 with p<0.05, whereas expression of BzpN-GFP in <i>aprA⁻, cfaD⁻, or qkgA⁻</i> cells did not cause a significant reduction in cell density at any measured timepoint (t-test). …”

Relative effect of selective enteric pathogens on disease severity during the epidemic. by S. M. Tafsir Hasan (5146871)

Microglia-plaque dynamics measured in the hippocampus of p38^+/+ and p38^KO AD mice. by David J. Braun (7107692)

“…<p>(A) Left panels: Representative images of tissue sections probed for microglia (Iba1: TxRed [red]), fibrillar amyloid deposits (Thioflavin S: FITC [green]), and Aβ peptides (6E10: Cy5 [purple]) obtained on a Nikon confocal microscope. …”

Construction strategy and verification of strains Ace1/Fbx23-TAP, Δ<i>fbx23</i>, and Re<i>fbx23</i>. by Zhongjiao Liu (11877464)

Conformational changes measured by fluorescence correlation spectrometry (FCS). by Sabina Eigenbrod (187226)

“…Wild-type (wt-rPrP, black columns) and mutant rPrP (TetraH>G-rPrP, purple columns, and H95G-rPrP, blue columns) showed no aggregation at 0.2% SDS. Decreasing the SDS concentration to 0.02% resulted in aggregation of all recombinant proteins to a different extent, being highest with wt-rPrP and lowest with H95G-rPrP. …”

Repression of its own gene by AphA. a) LacZ fusion. by Fengjun Sun (113206)

“…</b> The radioactively labeled DNA fragment from the 380th to 161st bp upstream of aphA was incubated with increasing amounts (lanes 1 to 4∶0, 15, 20, and 25 pmol, respectively) of purified His-AphA protein, and then subjected to 4% (w/v) polyacrylamide gel electrophoresis; the band of free DNA become weak with increasing amounts of His-AphA protein, and a retarded DNA band with decreased mobility turned up, which presumably represented the DNA-AphA complex. …”

Catalytic Polymerization of Butadiene in Aqueous Systems with Cationic Nickel(II) Complexes by Brigitte Korthals (2190643)

“…The cationic nickel(II) complexes [(η³-C₃H₅)Ni(SbPh₃)₂][B(3,5-(CF₃)₂C₆H₃)₄] (<b>2</b>) and [(η³-C₃H₅)Ni(SbPh₃)₂][Al(OC(CF₃)₃)₄] (<b>3</b>) were prepared and their polymerization activities in aqueous systems were compared with [(η³-C₃H₅)Ni(η⁶-BHT)][B(3,5-(CF₃)₂C₆H₃)₄] (<b>1</b>) (BHT = 3,5-di-<i>tert</i>-butyl-4-hydroxytoluene). …”