Image_1_Disulfiram Transcends ALDH Inhibitory Activity When Targeting Ovarian Cancer Tumor-Initiating Cells.jpeg by Michael W. Caminear (12252425)

“…<p>Epithelial ovarian cancer (EOC) is a global health burden and remains the fifth leading cause of cancer related death in women worldwide with the poorest five-year survival rate of the gynecological malignancies. …”

PAC-1 activation counteracts impaired NSCs under hypoglycaemic <i>milieu via</i> the PKA-dependent pathway. by Shiva Mansouri (2838086)

Pattern of COVID-19 Epidemics in Japan Influenced by Control Measures by Tomokazu Konishi (8887187)

“…</b> The increase or decrease in classes of SARS-CoV2 variants were estimated by analysing the published sequence with an objective multivariate analysis. …”

Infection of CD4 T cells with HIV 89.6 and JR-CSF by Rachel S. Resop (9238645)

Melatonin affects hypoxia-inducible factor 1α and ameliorates delayed brain injury following subarachnoid hemorrhage via H19/miR-675/HIF1A/TLR4 by Zhijian Xu (486851)

FOXO1 Suppresses SMAD-Induced <i>Fshb</i> Gene Expression. by Chung Hyun Park (665717)

Expected change in the mass-specific fecundity (in percentage) for a female of a given mass at a given latitude under predicted climate change scenarios. by Mariana Álvarez-Noriega (14275263)

“…<p>The colours show the reduction in the percentage change in mass-specific fecundity, with the largest increase in yellow and the largest decrease in black. RCP2.6 and RCP8.5 scenarios are a low- and very high-emission scenario, respectively. …”

NADPH oxidation and H₂O₂ production by Bs3 and Bs3_S211A. by Christina Krönauer (11301989)

“…NADPH oxidation was monitored via decrease of absorbance at 340 nm. Yucasin and methimazole (MMI) were dissolved in DMSO and added at a final concentration of 50 μM. …”

Side scatter distribution of U-CH1 cells maintained in normoxic (20% O₂) or hypoxic (2% O₂) conditions, with or without rCCN2. by Priya Patel (679595)

Neutralizing responses induced by Env proteins were overall low and sporadic. by Mitch Brinkkemper (10340361)

CX3CR1^-/- impaired left ventricular function in Coxsackievirus B3-infected mice. by Irene Müller (4351060)

Mitochondrial dysfunction in sIBM patients. by Yoshitsugu Oikawa (9721356)

The CDC’s %ILI (Influenza like illnesses) and the performance of multiple machine learning ensemble approaches that combine the 5 weak predictors to produce a single estimate are d... by Mauricio Santillana (528516)

Hedgehog signalling is required continuously from 16hpf for correct habenular development. by Caroline Halluin (3158562)

“…Treatment from 18 hpf results in either a similar abrogation of <i>cxcr4b</i> and <i>brn3a</i> expression (respectively n = 6/11 and n = 6/8) or in a strong decrease (n = 5/11 and n = 2/8, representative pictures in B’ and F’). …”

Pathways identified by IPA connects Bacopa to memory, neuroprotection and AD. by How-Wing Leung (4385896)

“…Explanation of the numbered connections: (1) ATF4 and NRF2 functionally interact with each other [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref040" target="_blank">40</a>–<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref043" target="_blank">43</a>]. (2) ATF4 is implicated in memory [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref059" target="_blank">59</a>–<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref062" target="_blank">62</a>]. (3) NRF is implicated in memory [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref063" target="_blank">63</a>–<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref067" target="_blank">67</a>]. (4) Translation initiation factor eIF2-alpha stimulates translation of ATF4 [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref068" target="_blank">68</a>–<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref071" target="_blank">71</a>]. (5) eIF2-alpha is implicated in memory formation [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref072" target="_blank">72</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref073" target="_blank">73</a>]. (6) ATF4 has been implicated in Alzheimer’s disease (AD) [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref074" target="_blank">74</a>–<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref078" target="_blank">78</a>]. (7) NRF2 has also been linked to AD [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref063" target="_blank">63</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref065" target="_blank">65</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref067" target="_blank">67</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref079" target="_blank">79</a>]. (8) NRF2 plays a critical role in neuroprotection [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref080" target="_blank">80</a>–<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref083" target="_blank">83</a>]. (9) FOXO3 mediates oxidative stress-induced neuronal cell death [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref084" target="_blank">84</a>–<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref087" target="_blank">87</a>]. …”

Slow Proton Exchange in Aqueous Solution. Consequences of Protonation and Hydration within the Central Cavity of Preyssler Anion Derivatives, [|M(H₂O)|⊃P₅W<su... by Kee-Chan Kim (2537014)

“…The rates increased as the pH was lowered, while the rate decreased to a limit of no observable exchange at pH 7. …”

Slow Proton Exchange in Aqueous Solution. Consequences of Protonation and Hydration within the Central Cavity of Preyssler Anion Derivatives, [|M(H₂O)|⊃P₅W<su... by Kee-Chan Kim (2537014)

“…The rates increased as the pH was lowered, while the rate decreased to a limit of no observable exchange at pH 7. …”

Slow Proton Exchange in Aqueous Solution. Consequences of Protonation and Hydration within the Central Cavity of Preyssler Anion Derivatives, [|M(H₂O)|⊃P₅W<su... by Kee-Chan Kim (2537014)

“…The rates increased as the pH was lowered, while the rate decreased to a limit of no observable exchange at pH 7. …”

Slow Proton Exchange in Aqueous Solution. Consequences of Protonation and Hydration within the Central Cavity of Preyssler Anion Derivatives, [|M(H₂O)|⊃P₅W<su... by Kee-Chan Kim (2537014)

“…The rates increased as the pH was lowered, while the rate decreased to a limit of no observable exchange at pH 7. …”

Slow Proton Exchange in Aqueous Solution. Consequences of Protonation and Hydration within the Central Cavity of Preyssler Anion Derivatives, [|M(H₂O)|⊃P₅W<su... by Kee-Chan Kim (2537014)

“…The rates increased as the pH was lowered, while the rate decreased to a limit of no observable exchange at pH 7. …”