Image5_Analysis of Brain Lipids in the Early-Onset Tay–Sachs Disease Mouse Model With the Combined Deficiency of β-Hexosaminidase A and Neuraminidase 3.jpg by Melike Can (13210755)

“…</p><p>Histochemical studies showed a decrease in the myelin level and axonal degeneration indicating neuronal pathology in the brain of Hexa−/−Neu3−/− mice. …”

Identifying cyst initiation candidate genes through mRNA sequencing <i>Pkd2</i> mouse kidneys at pre-cystic and early cystic time points. by Abigail O. Smith (11883787)

“…Colored dots indicate FDR <0.05, red indicates increased and blue decreased in Experimental vs Control. Plot was cropped for better visualization. (*) Data point moved for better visualization: Pkd2 [Log2(FC) = -1.13, -Log10(FDR) = 93.97], Cdkl1 [Log2(FC) = 0.42, -Log10(FDR) = 26.30]. …”

The HMR C-terminus is required for HMR localization in proximity to centromeres and HP1a-bound chromatin (related to Fig 4). by Andrea Lukacs (3752956)

Proliferation and ‘memory generation potential’ of CD62Lhi memory cells increases with time after infection. by Matthew D. Martin (803107)

In individuals affected by PCA, there is a significant downregulation of genes associated with the cholesterol biosynthetic pathway. by Leemon Nikhila (22250736)

Table_5_Identification and Confirmation of the miR-30 Family as a Potential Central Player in Tobacco-Related Head and Neck Squamous Cell Carcinoma.xlsx by Tingting Zhang (264633)

“…Moreover, we uncovered that KRAS might be the potential target gene of miR-30e-5p or miR-30b-5p. Thus, our data clearly showed that decreased expression of miR-30e-5p or miR-30b-5p may play a crucial role in cancer development, especially that of tobacco-induced HNSCC, and may be a novel candidate biomarker and target for this HNSCC subtype.…”

Stability of LIKE values over time for the original and the alternative dynamics for intermediate decrease speed (LHW = 2880), high partner selectivity (LPS = 0.99) and three diffe... by Tonko W. Zijlstra (10521607)

Ribosome profiling uncovers selective mRNA translation associated with eIF2 phosphorylation in erythroid progenitors by Nahuel A. Paolini (5081699)

“…Treatment of erythroblasts with Tunicamycin (Tm) increased phosphorylation of eIF2 2-fold. At a false discovery rate of 1%, ribosome density was increased for 147 transcripts, among which transcriptional regulators such as <i>Atf4</i>, <i>Tis7/Ifrd1</i>, <i>Pnrc2</i>, <i>Gtf2h</i>, <i>Mbd3</i>, <i>JunB</i> and <i>Kmt2e</i>. …”

Data_Sheet_1_Manipulation of an α-glucosidase in the industrial glucoamylase-producing Aspergillus niger strain O1 to decrease non-fermentable sugars production and increase glucoa... by Wenzhu Guo (501328)

“…The results showed the transglycosylation product panose was decreased by more than 88.0% in agdA/agdB double knock-out strains than strain O1. …”

Cross-network FC among RSNs for CN group (A), FBSS group (B), and difference (C), respectively. by Peter A. Pahapill (8468607)

Andexanet alfa effectively reverses edoxaban anticoagulation effects and associated bleeding in a rabbit acute hemorrhage model by Genmin Lu (5029949)

“…</p><p>Materials and methods</p><p><i>In vitro</i> studies characterized the interaction of andexanet with edoxaban and its ability to reverse edoxaban-mediated anti-FXa activity. In a rabbit model of surgically induced, acute hemorrhage, animals received edoxaban vehicle+andexanet vehicle (control), edoxaban (1 mg/kg)+andexanet vehicle, edoxaban+andexanet (75 mg, 5-minute infusion, 20 minutes after edoxaban), or edoxaban vehicle+andexanet prior to injury.…”

The time course of the fraction of intact DOPG/DOPC (40/60)-GUVs and the rate constant of rupture and electrofusion at different frequencies of DC pulses under <i>σ</i>_e... by Md. Tariqul Islam Bhuiyan (18794375)

Exposing cells twice with 2-hr M64HCl treatment during a 24-hour period stimulated prolonged epithelial monolayer wound closure in Caco-2 cells. by Sema Oncel (10152053)

The Catalytic Subunit of the System L1 Amino Acid Transporter (<i>Slc7a5</i>) Facilitates Nutrient Signalling in Mouse Skeletal Muscle by Nadège Poncet (527942)

“…These changes were associated with >50% decrease in S6K Thr389 phosphorylation in muscles from MS-<i>Slc7a5</i>-KO mice, indicating reduced mTOR-S6K pathway activation, despite no significant differences in lean tissue mass between groups on the same diet. …”

Effects of Combined CCR5/Integrase Inhibitors-Based Regimen on Mucosal Immunity in HIV-Infected Patients Naïve to Antiretroviral Therapy: A Pilot Randomized Trial by Sergio Serrano-Villar (517286)

“…In the duodenum, the quadruple regimen resulted in greater CD8⁺ T-cell density decline, greater normalization of mucosal CCR5⁺CD4⁺ T-cells and increase of the naïve/memory CD8⁺ T-cell ratio, and a greater decline of sCD14 levels and duodenal HIV DNA levels (P = 0.004 and P = 0.067, respectively), with no changes in HIV RNA in plasma or tissue. …”

LncRNA GAS5 knocked-down THP-1 cells treated with 75 μg/mL oxLDL reduced cell apoptosis. by Lei Chen (54296)

“…<p><b>A</b>. RT-PCR analysis of lncRNA GAS5 expression in NC and lncRNA GAS knocked-down cells. …”

Video 2; Footage of several trials in the experiment from the participant's point of view (.avi) from The confusion effect when attacking simulated three-dimensional starling flock... by Benedict G. Hogan (3604364)

A case of diffuse astrocytoma (Grade II, LGG). by Osamu Togao (470739)

Predicted mutation selection windows for <i>E</i>. <i>coli</i> exposed to ampicillin. by Fabrizio Clarelli (3622889)

“…The blue line represents the wild-type strain based on the fits shown in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1008106#pcbi.1008106.g005" target="_blank">Fig 5</a>, and the red line represents a strain with a theoretical resistance mutation that decreases the binding rate (<i>k</i>_f) 100-fold and imparts a 15% fitness cost. …”

Chain Conformation, Molecular Dynamics, and Thermal Properties of Poly(<i>n</i>‑methylene 2,5-furanoates) as a Function of Methylene Unit Sequence Length by George Papamokos (1595743)

“…Poly­(<i>n</i>-methylene 2,5-furanoates) is a family of biobased polymers with outstanding gas barrier and mechanical properties and with the potential to frame the future in certain applications (e.g., food packaging, fibers, and engineering thermoplastics). …”