CDK5 Regulates Paclitaxel Sensitivity in Ovarian Cancer Cells by Modulating AKT Activation, p21Cip1- and p27Kip1-Mediated G1 Cell Cycle Arrest and Apoptosis by Shu Zhang (22238)

“…<div><p>Cyclin-dependent kinase 5 (CDK5) is a cytoplasmic serine/ threonine kinase. …”

Identification of OPG147 as a conserved inhibitor of the cGAS-mediated pathway. by Xue-Mei Yi (18851202)

Synthesis and Pharmacological Evaluation of Different Piperine Analogs for Therapeutic Potential to Prevent ER Stress by Hammad, Ayat Samir

“…Our findings indicate that exposure to tunicamycin (0.5 µg/mL) for 2 hours induces the expression of GRP78 and CHOP, and causes a significant reduction in renal cell viability. …”
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Image_3_Case Report: Changes in Cytokine Kinetics During the Course of Disease in a Japanese Patient With Multisystem Inflammatory Syndrome in Children.jpg by Satoshi Takasago (11163471)

Image_2_Case Report: Changes in Cytokine Kinetics During the Course of Disease in a Japanese Patient With Multisystem Inflammatory Syndrome in Children.jpg by Satoshi Takasago (11163471)

Image_1_Case Report: Changes in Cytokine Kinetics During the Course of Disease in a Japanese Patient With Multisystem Inflammatory Syndrome in Children.jpg by Satoshi Takasago (11163471)

Three-dimensional reconstructions and quantitative measurements of wild-type and <i>Vcan</i> exon 7 AV associated cushions in E13.5 pc hearts. by Tara A. Burns (525354)

“…A significant (*p value 0.05 panel G) decrease in volume (0.58x) of the dorsal mesenchymal protrusion (DM) was measured. …”

Geometric interpretation and data visualisation equivalent describing the DI algorithmic pipeline. by Borjan Milinkovic (21349908)

Genes associated with androgen-induced decrease in H3K27me3 mark in the gene body and overlapping with promoters and distal enhancers involving long-range regulation of gene expres... by Sambit Roy (5463899)

“…D: Average number of H3K27me3 peaks per 50bp overlapping with the promoter regions of 160 genes in the control samples and 55 genes in the DHT-treated samples. E: Degree analysis of enhancer-gene interactions for genes associated with significant decrease in H3K27me3 peaks in their enhancer regions with respect to DHT treatment. …”

Mean blood glucose responses (mmol/L) to an oral blood glucose bolus 2g/kg during a 120-minute period and mean area under the curve (mmol/L.min) during the oral blood glucose toler... by Elsie D. Oduor (22521785)

Mean blood glucose responses (mmol/L) to an oral blood glucose bolus 2g/kg during a 120-minute period and mean area under the curve (mmol/L.min) during the oral blood glucose toler... by Elsie D. Oduor (22521785)

Pathological pathways associated with SARS-CoV-2 infection in hamsters and COVID-19 patients were upregulated in hamsters challenged with SARS-CoV-2. by Malika Aid (7303874)

“…<p><b>(A-B</b>) Dot plots of differentially expressed genes increased in infected hamsters at 4 dpi that are upregulated (red) or downregulated (blue) in COVID-19 infected patients or the lung of hamsters infected with SARS-CoV-2. …”

Co-silencing of Nb<i>ATG3</i> or Nb<i>ATG5</i> with Nb<i>eIF4A</i> in <i>N</i>. <i>benthamiana</i> plants and immunoblot analysis of RSV CP accumulation in the silenced plants. by Xiangxiang Zhang (498122)

“…<b>(B–D)</b> Decreased expression levels of Nb<i>ATG3</i> <b>(B)</b>, Nb<i>ATG5</i> <b>(C)</b> and Nb<i>eIF4A</i> <b>(D)</b> in the corresponding co-silenced plants, as revealed by RT-qPCR, indicating the efficient silencing of these genes. …”

Comparison between normal and failing basal-epicardial myocyte models showing the characteristic EP of a failing myocyte: (a) longer action potential (as seen in Fig. 1 of [2]) (to... by Aditya V. S. Ponnaluri (3164673)

Averaged absorption spectra as a function of cost compared to the far-red adapted cyanobacteria <i>Acarychloris marina</i> [62] for (A) 40% of available visible light below 700nm,... by Callum Gray (2691769)

New hydrazonoindolin-2-ones: Synthesis, exploration of the possible anti-proliferative mechanism of action and encapsulation into PLGA microspheres by Mohamed I. Attia (2392672)

“…In addition, compound <b>7e</b> increased phosphorylated tyrosine (p-Tyr) levels nearly two-fold with an apparent IC₅₀ value of 3.8 μM. …”

The overall heart morphology is not altered if valves are malformed. by Christian Meyer (6035)

A Ligand-Based Drug Design. Discovery of 4‑Trifluoromethyl-7,8-pyranocoumarin as a Selective Inhibitor of Human Cytochrome P450 1A2 by Jiawang Liu (1330971)

“…With a 5 min preincubation in the presence of NADPH, 0.01 μM 7,8-furanoflavone completely inactivates P450 1A2 but does not influence the activities of P450s 1A1 and 1B1. …”

Chondrocytes differentiation and osteoblasts proliferation were impaired in mutant long bones. by Xiaoquan Zhu (589276)

“…(G, H) Quantification of the number of osteoblasts surrounding trabecular bones (G) and the number of trabecular bones per unit area (H) at the radii and ulnae of <i>Tnni2^+/K175del</i> mice (n = 5) and wild-type controls (n = 4) at P12. The trabecular bone and the number of osteoblasts were decreased on average by 53% and 57% in heterozygous DA2B mice, respectively. …”

Presentation_1_1,4-dihydroxy quininib modulates the secretome of uveal melanoma tumour explants and a marker of oxidative phosphorylation in a metastatic xenograft model.pdf by Kayleigh Slater (6273734)

“…In an orthotopic, cell line-derived xenograft model of MUM, 1,4-dihydroxy quininib administered intraperitoneally at 25 mg/kg significantly decreases ATP5B expression (p = 0.03), a marker of oxidative phosphorylation. …”