Upon Photoactivation in <i>m</i>Nrp1-Cherry-Positive Vesicles, α5-PA-GFP Recycles Back to Membrane Adhesions by Donatella Valdembri (268183)

“…The time-lapse plot (lower panel) shows that the α5-PA-GFP fluorescence intensity decreases in the vesicles, while it increases at the plasma membrane. …”

Leveraging Peripheral CB1 Antagonism in 1,4,5,6-Tetrahydropyridazine-Based Amidine Substituted Sulfonyl Analogs for Treating Metabolic Disorders by Pinaki Bhattacharjee (11971366)

“…Initial synthesis included compounds <b>10a</b>–<b>u</b>, followed by expansion into distinct amidine groups <b>(11a–18e</b>) for detailed structure–activity relationships. …”

Inactivation of <i>Six5</i>, <i>Dmpk</i> or <i>Mbnl1</i> does not affect Pavlovian contextual fear conditioning. by Anna Matynia (46702)

“…Baseline activity levels (arbitrary units) prior to the foot shock (panels iii) and activity bursts (velocity, cm/s, panels iv) are shown. A) <i>Six5^−/−</i> (white, n = 7) mutant mice display no differences in context fear conditioning freezing, activity suppression, activity level or activity burst phenotypes compared to the <i>Six5^+/+</i> wild type littermate controls (black, n = 6). …”

Leveraging Peripheral CB1 Antagonism in 1,4,5,6-Tetrahydropyridazine-Based Amidine Substituted Sulfonyl Analogs for Treating Metabolic Disorders by Pinaki Bhattacharjee (11971366)

“…Initial synthesis included compounds <b>10a</b>–<b>u</b>, followed by expansion into distinct amidine groups <b>(11a–18e</b>) for detailed structure–activity relationships. …”

Leveraging Peripheral CB1 Antagonism in 1,4,5,6-Tetrahydropyridazine-Based Amidine Substituted Sulfonyl Analogs for Treating Metabolic Disorders by Pinaki Bhattacharjee (11971366)

“…Initial synthesis included compounds <b>10a</b>–<b>u</b>, followed by expansion into distinct amidine groups <b>(11a–18e</b>) for detailed structure–activity relationships. …”

DataSheet_1_Critical Roles of Spätzle5 in Antimicrobial Peptide Production Against Escherichia coli in Tenebrio molitor Malpighian Tubules.docx by Maryam Ali Mohammadie Kojour (11843237)

“…Here, we indicated that TmSpz5 has a functional role in response to bacterial infections. …”

Image_5_Combination of single-nucleus and bulk RNA-seq reveals the molecular mechanism of thalamus haemorrhage-induced central poststroke pain.tif by Tianfeng Huang (13896228)

Leveraging Peripheral CB1 Antagonism in 1,4,5,6-Tetrahydropyridazine-Based Amidine Substituted Sulfonyl Analogs for Treating Metabolic Disorders by Pinaki Bhattacharjee (11971366)

“…Initial synthesis included compounds <b>10a</b>–<b>u</b>, followed by expansion into distinct amidine groups <b>(11a–18e</b>) for detailed structure–activity relationships. …”

Leveraging Peripheral CB1 Antagonism in 1,4,5,6-Tetrahydropyridazine-Based Amidine Substituted Sulfonyl Analogs for Treating Metabolic Disorders by Pinaki Bhattacharjee (11971366)

“…Initial synthesis included compounds <b>10a</b>–<b>u</b>, followed by expansion into distinct amidine groups <b>(11a–18e</b>) for detailed structure–activity relationships. …”

Data_Sheet_1_Asthmatic Bronchial Smooth Muscle Increases CCL5-Dependent Monocyte Migration in Response to Rhinovirus-Infected Epithelium.docx by Benoit Allard (522753)

“…However, we demonstrated that CCL5 was further increased in the asthmatic BSM co-culture and that anti-CCL5 blocking antibody significantly decreased monocyte migration induced by HRV-infected BE. …”

The 5′ Flanking Region and Intron1 of the Bovine Prion Protein Gene (<em>PRNP</em>) Are Responsible for Negative Feedback Regulation of the Prion Protein by Guangai Xue (179316)

“…The PrP-expressing plasmid pEF-boPrP and luciferase-expressing plasmids containing the partial promoter fragment of <em>PRNP</em> incorporating naturally occurring single-nucleotide or insertion/deletion polymorphisms were transfected into N2a cells. Transfection of pEF-boPrP induced PrP overexpression and decreased the promoter activity of <em>PRNP</em> in the wild-type haplotype (23-bp Del, 12-bp Del, and −47C). …”

Table_5_Maternal High-Protein and Low-Protein Diets Perturb Hypothalamus and Liver Transcriptome and Metabolic Homeostasis in Adult Mouse Offspring.XLSX by Lisa J. Martin (228675)

“…Perinatal HP/LC and LP/HC exposures resulted in a decreased ability to clear glucose in the offspring, with reduced baseline insulin and glucose concentrations in the LP/HC group and a reduced insulin response post-glucose challenge in the HP/LC group. …”

Image_5_Dragon fruit-kiwi fermented beverage: In vitro digestion, untargeted metabolome analysis and anti-aging activity in Caenorhabditis elegans.JPEG by Zizhong Tang (4104571)

Image_5_Function and Mechanism of Trimetazidine in Myocardial Infarction-Induced Myocardial Energy Metabolism Disorder Through the SIRT1–AMPK Pathway.JPEG by Xiu-ying Luo (10984614)

“…The current study set out to evaluate the effect and mechanism of TMZ on MEM disorder induced by myocardial infarction (MI). Firstly, a MI mouse model was established by coronary artery ligation, which was then treated with different concentrations of TMZ (5, 10, and 20 mg kg^–1 day^–1). …”

Image_5_Underwater Acoustic Ecology Metrics in an Alaska Marine Protected Area Reveal Marine Mammal Communication Masking and Management Alternatives.PNG by Christine M. Gabriele (3297708)

“…RA was approximated from the quietest 5th percentile noise statistics based on a year (2011) of continuous audio data from a hydrophone in GBNP, in the frequency bands of whale and seal sounds of interest: humpback “whup” calls (50–700 Hz, 143 dB re 1 μPa source level, SL); humpback song (224–708 Hz, 175 dB SL), and harbor seal roars (4–500 Hz, 144 dB SL). …”

Supplementary Revised Figure S2 from MUC16 Regulates TSPYL5 for Lung Cancer Cell Growth and Chemoresistance by Suppressing p53 by Imayavaramban Lakshmanan (281140)

Video_5_Intravital Multiphoton Microscopy of the Ocular Surface: Alterations in Conventional Dendritic Cell Morphology and Kinetics in Dry Eye Disease.MP4 by Arsia Jamali (8484990)

Image_5_ATF3 Sustains IL-22-Induced STAT3 Phosphorylation to Maintain Mucosal Immunity Through Inhibiting Phosphatases.JPEG by Doaa Glal (5927738)

Image_5_Breathing Abnormalities During Sleep and Wakefulness in Rett Syndrome: Clinical Relevance and Paradoxical Relationship With Circulating Pro-oxidant Markers.pdf by Silvia Leoncini (383432)

“…</p>Methods<p>Female patients with a clinical diagnosis of typical RTT (n = 66), MECP2 gene mutation, and apneas were enrolled (mean age: 12.5 years). …”

Supplementary Revised Figure S3 from MUC16 Regulates TSPYL5 for Lung Cancer Cell Growth and Chemoresistance by Suppressing p53 by Imayavaramban Lakshmanan (281140)

“…<p>Chemoresistance properties of MUC16 and effect of cisplatin on apoptosis of MUC16 knockdown cells. A & B, MUC16 knockdown (H1975-shMUC16 seq1 and 2) cells were highly sensitive to cisplatin (A) and gemcitabine (B). …”