Design of Benzyl-triazolopyrimidine-Based NADPH Oxidase Inhibitors Leads to the Discovery of a Potent Dual Covalent NOX2/MAOB Inhibitor by Beatrice Noce (16540800)

“…NADPH oxidases (NOXs) are enzymes dedicated to reactive oxygen species (ROS) production and are implicated in cancer, neuroinflammation, and neurodegenerative diseases. VAS2870 is a covalent inhibitor of mainly NOX2 and NOX5. It alkylates a conserved active-site cysteine, blocking productive substrate binding. …”

Data_Sheet_1_Membrane-Located Expression of Thioesterase From Acinetobacter baylyi Enhances Free Fatty Acid Production With Decreased Toxicity in Synechocystis sp. PCC6803.docx by Shajia Afrin (6010424)

“…To realize this, we localized a leaderless thioesterase (AcTesA) from Acinetobacter baylyi on the cytosolic side of the inner membrane of Synechocystis sp. …”

Intrathecal KN93 injection attenuated fentanyl-induced hyperalgesia and decreased the level of <i>p</i>-CaMKIIα in spinal cord but not CeLC in OIH rats. by Zhen Li (1234644)

Effects of Zeolite Structural Confinement on Adsorption Thermodynamics and Reaction Kinetics for Monomolecular Cracking and Dehydrogenation of <i>n</i>‑Butane by Amber Janda (1674589)

Fructose diet alleviates acetaminophen-induced hepatotoxicity in mice by Sungjoon Cho (4385851)

“…Fructose-treated mice exhibited (~1.5 fold) higher basal glutathione levels and (~2 fold) lower basal (mRNA and activity) levels of Cyp1a2 and Cyp2e1, suggesting decreased bioactivation of APAP and increased detoxification of toxic metabolite in fructose-fed mice. …”

Datasheet1_Acquired von Willebrand syndrome (AVWS) type 2, characterized by decreased high molecular weight multimers, is common in children with severe pulmonary hypertension (PH)... by Ivonne Wieland (14112981)

“…Notably, 3 of 5 patients (60%) with normal VWF:Ac/VWF:Ag ratio >0.7 had abnormal VWF multimers, indicating AVWS type 2. …”

Electrical stimulation decreased M1/M2 ratio mainly through reducing M1 marker-positive macrophages during wound healing <i>in vivo</i>. by Cristian O. Hernandez (18831333)

(a) As the condensate is being squeezed in the <em>xy</em> plane, the peak value of the mathcal {F}_z increases with respect to ω_⊥/ω, where ω_⊥ is the trapping... by Shu-Wei Song (557396)

“…<p><strong>Figure 5.</strong> (a) As the condensate is being squeezed in the <em>xy</em> plane, the peak value of the \mathcal {F}_z increases with respect to ω_⊥/ω, where ω_⊥ is the trapping frequency in the squeezing direction. …”

Table_1_Effects of social housing on alcohol intake in mice depend on the non-social environment.XLSX by Michael C. Johnson (1924801)

“…</p>Methods<p>Adult C57BL/6 J mice were housed in either standard shoebox cages or in automated Herdsman 2 (HM2) cages and exposed to a two-bottle choice procedure with 3% or 6% ethanol versus water for 5 days. …”

Reduced Long-Term Relative Survival in Females and Younger Adults Undergoing Cardiac Surgery: A Prospective Cohort Study by Tone Bull Enger (668126)

“…The observed 30-day, 1-, 3- and 5-year mortality rates were 2.2%, 4.4%, 8.2% and 13.8%, respectively, and remained constant throughout the study period. …”

Metallization of a Hypervalent Radical Dimer: Molecular and Band Perspectives by John S. Tse (1321242)

“…Variable pressure and temperature conductivity measurements on the bisthiaselenazolyl radical dimer [<b>1a</b>]₂ have established the presence of a weakly metallic state over the pressure range 5−9 GPa. …”

Metallization of a Hypervalent Radical Dimer: Molecular and Band Perspectives by John S. Tse (1321242)

“…Variable pressure and temperature conductivity measurements on the bisthiaselenazolyl radical dimer [<b>1a</b>]₂ have established the presence of a weakly metallic state over the pressure range 5−9 GPa. …”

Metallization of a Hypervalent Radical Dimer: Molecular and Band Perspectives by John S. Tse (1321242)

“…Variable pressure and temperature conductivity measurements on the bisthiaselenazolyl radical dimer [<b>1a</b>]₂ have established the presence of a weakly metallic state over the pressure range 5−9 GPa. …”

Metallization of a Hypervalent Radical Dimer: Molecular and Band Perspectives by John S. Tse (1321242)

“…Variable pressure and temperature conductivity measurements on the bisthiaselenazolyl radical dimer [<b>1a</b>]₂ have established the presence of a weakly metallic state over the pressure range 5−9 GPa. …”

Metallization of a Hypervalent Radical Dimer: Molecular and Band Perspectives by John S. Tse (1321242)

“…Variable pressure and temperature conductivity measurements on the bisthiaselenazolyl radical dimer [<b>1a</b>]₂ have established the presence of a weakly metallic state over the pressure range 5−9 GPa. …”

Passive transfer of humanized anti-NS1 mAb 33D2 into DENV-inoculated mice decreases viral titer and NS1 level in mouse sera. by Sen-Mao Tien (12481273)

<i>Zip88E</i>^<i>Δ/Δ</i> larvae have decreased <i>MtnB</i>:<i>EYFP</i> expression. by Christopher D. Richards (4246669)

“…C) There is an approximate 5 fold decrease in <i>MtnB</i>:<i>EYFP</i> expression in <i>Zip88E</i>^<i>Δ/Δ</i> larvae compared to controls when raised on basal media. …”

Table_2_NOTCH1 mutation associates with impaired immune response and decreased relapse-free survival in patients with resected T1-2N0 laryngeal cancer.docx by Xiao-yang Gong (13103400)

“…</p>Results<p>To the best to our knowledge, we present for the first time an overview of the genomic mutation spectrum of early-stage laryngeal cancers. A total of 469 genomic alterations were detected in 211 distinct cancer-relevant genes, and the genes found to be mutated in more than five patients (>10%) included tumor protein p53 (TP53, 78.5%), FAT atypical cadherin 1 (FAT1, 26%), LDL receptor related protein 1B (LRP1B, 19%), cyclin dependent kinase inhibitor 2A (CDKN2A, 17%), tet methylcytosine dioxygenase 2 (TET2, 17%), notch receptor 1 (NOTCH1, 12%) and neuregulin 1 (NRG1, 12%). …”

Image_2_NOTCH1 mutation associates with impaired immune response and decreased relapse-free survival in patients with resected T1-2N0 laryngeal cancer.tif by Xiao-yang Gong (13103400)

“…</p>Results<p>To the best to our knowledge, we present for the first time an overview of the genomic mutation spectrum of early-stage laryngeal cancers. A total of 469 genomic alterations were detected in 211 distinct cancer-relevant genes, and the genes found to be mutated in more than five patients (>10%) included tumor protein p53 (TP53, 78.5%), FAT atypical cadherin 1 (FAT1, 26%), LDL receptor related protein 1B (LRP1B, 19%), cyclin dependent kinase inhibitor 2A (CDKN2A, 17%), tet methylcytosine dioxygenase 2 (TET2, 17%), notch receptor 1 (NOTCH1, 12%) and neuregulin 1 (NRG1, 12%). …”

Table_4_NOTCH1 mutation associates with impaired immune response and decreased relapse-free survival in patients with resected T1-2N0 laryngeal cancer.docx by Xiao-yang Gong (13103400)

“…</p>Results<p>To the best to our knowledge, we present for the first time an overview of the genomic mutation spectrum of early-stage laryngeal cancers. A total of 469 genomic alterations were detected in 211 distinct cancer-relevant genes, and the genes found to be mutated in more than five patients (>10%) included tumor protein p53 (TP53, 78.5%), FAT atypical cadherin 1 (FAT1, 26%), LDL receptor related protein 1B (LRP1B, 19%), cyclin dependent kinase inhibitor 2A (CDKN2A, 17%), tet methylcytosine dioxygenase 2 (TET2, 17%), notch receptor 1 (NOTCH1, 12%) and neuregulin 1 (NRG1, 12%). …”