Image_2_The S2–S3 Loop of Kv7.4 Channels Is Essential for Calmodulin Regulation of Channel Activation.tif by Wenhui Zhuang (10007378)

“…Kv7.4 channels co-expressed with wild-type (WT) CaM show inhibited activation when intracellular calcium levels increase, while Kv7.4 channels co-expressed with CaM₁₂₃₄ or CaM₃ are insensitive to calcium. Mutations C156A, C157A, C158V, R159, and R161A, which are located within the Kv7.4 S2–S3 loop, dramatically facilitate activation of Kv7.4 channels co-expressed with WT CaM but have no effect on activation of Kv7.4 channels co-expressed with CaM₃, indicating that these five mutations decrease the inhibitory effect of Ca²⁺/CaM. …”

Image_7_The S2–S3 Loop of Kv7.4 Channels Is Essential for Calmodulin Regulation of Channel Activation.tif by Wenhui Zhuang (10007378)

“…Kv7.4 channels co-expressed with wild-type (WT) CaM show inhibited activation when intracellular calcium levels increase, while Kv7.4 channels co-expressed with CaM₁₂₃₄ or CaM₃ are insensitive to calcium. Mutations C156A, C157A, C158V, R159, and R161A, which are located within the Kv7.4 S2–S3 loop, dramatically facilitate activation of Kv7.4 channels co-expressed with WT CaM but have no effect on activation of Kv7.4 channels co-expressed with CaM₃, indicating that these five mutations decrease the inhibitory effect of Ca²⁺/CaM. …”

Image_4_The S2–S3 Loop of Kv7.4 Channels Is Essential for Calmodulin Regulation of Channel Activation.tif by Wenhui Zhuang (10007378)

“…Kv7.4 channels co-expressed with wild-type (WT) CaM show inhibited activation when intracellular calcium levels increase, while Kv7.4 channels co-expressed with CaM₁₂₃₄ or CaM₃ are insensitive to calcium. Mutations C156A, C157A, C158V, R159, and R161A, which are located within the Kv7.4 S2–S3 loop, dramatically facilitate activation of Kv7.4 channels co-expressed with WT CaM but have no effect on activation of Kv7.4 channels co-expressed with CaM₃, indicating that these five mutations decrease the inhibitory effect of Ca²⁺/CaM. …”

Image_6_The S2–S3 Loop of Kv7.4 Channels Is Essential for Calmodulin Regulation of Channel Activation.tif by Wenhui Zhuang (10007378)

“…Kv7.4 channels co-expressed with wild-type (WT) CaM show inhibited activation when intracellular calcium levels increase, while Kv7.4 channels co-expressed with CaM₁₂₃₄ or CaM₃ are insensitive to calcium. Mutations C156A, C157A, C158V, R159, and R161A, which are located within the Kv7.4 S2–S3 loop, dramatically facilitate activation of Kv7.4 channels co-expressed with WT CaM but have no effect on activation of Kv7.4 channels co-expressed with CaM₃, indicating that these five mutations decrease the inhibitory effect of Ca²⁺/CaM. …”

Image_8_The S2–S3 Loop of Kv7.4 Channels Is Essential for Calmodulin Regulation of Channel Activation.tif by Wenhui Zhuang (10007378)

“…Kv7.4 channels co-expressed with wild-type (WT) CaM show inhibited activation when intracellular calcium levels increase, while Kv7.4 channels co-expressed with CaM₁₂₃₄ or CaM₃ are insensitive to calcium. Mutations C156A, C157A, C158V, R159, and R161A, which are located within the Kv7.4 S2–S3 loop, dramatically facilitate activation of Kv7.4 channels co-expressed with WT CaM but have no effect on activation of Kv7.4 channels co-expressed with CaM₃, indicating that these five mutations decrease the inhibitory effect of Ca²⁺/CaM. …”

Image_9_The S2–S3 Loop of Kv7.4 Channels Is Essential for Calmodulin Regulation of Channel Activation.tif by Wenhui Zhuang (10007378)

“…Kv7.4 channels co-expressed with wild-type (WT) CaM show inhibited activation when intracellular calcium levels increase, while Kv7.4 channels co-expressed with CaM₁₂₃₄ or CaM₃ are insensitive to calcium. Mutations C156A, C157A, C158V, R159, and R161A, which are located within the Kv7.4 S2–S3 loop, dramatically facilitate activation of Kv7.4 channels co-expressed with WT CaM but have no effect on activation of Kv7.4 channels co-expressed with CaM₃, indicating that these five mutations decrease the inhibitory effect of Ca²⁺/CaM. …”

Data_Sheet_1_4DEMON: Integrating 40 Years of Data on PCB and Metal Contamination in Marine Sediments of the Belgian Part of the North Sea.docx by Hong Minh Le (10887786)

“…Trend analysis revealed a strong decrease in PCB concentrations in the nineteen eighties and nineties, followed by a slight increase over the last decade. …”

Image_1_The S2–S3 Loop of Kv7.4 Channels Is Essential for Calmodulin Regulation of Channel Activation.tif by Wenhui Zhuang (10007378)

“…Kv7.4 channels co-expressed with wild-type (WT) CaM show inhibited activation when intracellular calcium levels increase, while Kv7.4 channels co-expressed with CaM₁₂₃₄ or CaM₃ are insensitive to calcium. Mutations C156A, C157A, C158V, R159, and R161A, which are located within the Kv7.4 S2–S3 loop, dramatically facilitate activation of Kv7.4 channels co-expressed with WT CaM but have no effect on activation of Kv7.4 channels co-expressed with CaM₃, indicating that these five mutations decrease the inhibitory effect of Ca²⁺/CaM. …”

Image_3_The S2–S3 Loop of Kv7.4 Channels Is Essential for Calmodulin Regulation of Channel Activation.tif by Wenhui Zhuang (10007378)

“…Kv7.4 channels co-expressed with wild-type (WT) CaM show inhibited activation when intracellular calcium levels increase, while Kv7.4 channels co-expressed with CaM₁₂₃₄ or CaM₃ are insensitive to calcium. Mutations C156A, C157A, C158V, R159, and R161A, which are located within the Kv7.4 S2–S3 loop, dramatically facilitate activation of Kv7.4 channels co-expressed with WT CaM but have no effect on activation of Kv7.4 channels co-expressed with CaM₃, indicating that these five mutations decrease the inhibitory effect of Ca²⁺/CaM. …”

Table_1_Validation of online mindfulness-enhanced course for stress reduction in teachers.DOCX by Qun Ye (1702021)

“…Background<p>Mindfulness-based interventions have gained popularity as a means of reducing stress and increasing resilience among the preclinical population. …”

Group differences in the time course of Blood Oxygen Level-Dependent (BOLD) responses over the entire course of the pain experience. by Imanuel Lerman (6331049)

“…Treatment with nVNS significantly decreased the response of the postcentral gyrus during and after the application of noxious thermal stimuli (5 seconds each), up to 12 seconds after cessation of the painful stimulus. …”

Increasing dead cell burden in wounds resulted in increased pro-inflammatory cytokine levels. by Savita Khanna (252283)

“…Data (mean ±SD, n = 5) are presented as <i>pg</i> cytokine per <i>mg</i> wound tissue. *, <i>p</i><0.05 compared to IgG treated control side.…”

Jackknife analysis of the top environmental predictors used in the model. by Kylie M. Sage (4543402)

“…BIO5 = maximum temperature of the warmest month, BIO6 = minimum temperature of the coldest month, BIO8 = mean temperature of the wettest quarter, BIO7 = annual temperature range, BIO15 = precipitation seasonality, BIO18 = precipitation of the warmest quarter, elv = elevation.…”

Chloroquine (CQ) treatment blocks autophagosome–lysosome fusion and induces myopathy in the larva. by Jonathan Zirin (483506)

“…(M) Quantification of autophagy changes due to <i>Atg</i> gene knockdown in <i>Dmef2</i>–<i>Gal4</i>, <i>UAS</i>–<i>GFP</i>–<i>Atg8</i> larvae starved on low-nutrient food +2.5 mg/ml CQ for 6 h. Each of the 10 <i>UAS</i>–<i>Atg</i> RNAi transgenes tested caused a highly significant decrease (<i>p</i><.01) in the total area of GFP–Atg8 vesicles. …”

Glycolytic inhibitor 2-DG alters downstream AMPK and mTOR signaling, and neuronal gene expression, but does not affect Wnt signaling. by Roaya S. Alqurashi (11243136)

“…Representative western blots with quantified data showed 2-DG treatment at day 5 post-SE with pilocarpine inhibit mTOR signaling downstream activation by decreased pP70S6K^T389 and activating pAMPKα^T172. …”

Comparison between insulin and BIO effects on intracellular signaling. by Mounira Abiola (368118)

“…(<b>A</b>) Insulin increased GSK-3β^S9 phosphorylation in myotubes cultured in G5 or G25, whereas BIO had no effect. …”

Daily and seasonal changes of vocal activity of the Common Crane <i>Grus grus</i>: implications for conservation and monitoring efforts by Michał Budka (608553)

Data_Sheet_1_Supplementation with inulin reverses cognitive flexibility alterations and modulates the gut microbiota in high-fat-fed mice.docx by Gabriela González-Velázquez (20131497)

“…Statistically significant differences in alpha diversity for gut microbiota were observed using the Shannon, Simpson, and Chao1 indices. The I group showed a decrease in bacterial diversity compared to the HF group. …”

Table_1_Nocebo Effects of Clinical Communication and Placebo Effects of Positive Suggestions on Respiratory Muscle Strength.DOCX by Nina Zech (3601097)

“…After risk information, a decrease was observed in three of the parameters, with the highest extend in expiratory pressure by 4.4%. …”

Departures from the balance of excitation and inhibition do not effect assembly formation. by Lisandro Montangie (8816753)

“…<p>Mean clustering coefficient, mean global efficiency and modularity versus the inhibitory multiplicative factor <i>δ</i>_inh = {0.5, 0.8, 1.2, 1.5}, which scales the overall inhibitory matrix (see <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1007835#sec012" target="_blank">Methods</a>). …”