Image5_Sodium–Glucose CoTransporter-2 Inhibitor Empagliflozin Ameliorates Sunitinib-Induced Cardiac Dysfunction via Regulation of AMPK–mTOR Signaling Pathway–Mediated Autophagy.JPE... by Changzhen Ren (10649432)

“…We aimed to determine whether empagliflozin (EMPA), an SGLT2 inhibitor, has a protective role against sunitinib (SNT)-induced cardiac dysfunction in a mouse model.…”

DataSheet1_Sodium–Glucose CoTransporter-2 Inhibitor Empagliflozin Ameliorates Sunitinib-Induced Cardiac Dysfunction via Regulation of AMPK–mTOR Signaling Pathway–Mediated Autophagy... by Changzhen Ren (10649432)

“…We aimed to determine whether empagliflozin (EMPA), an SGLT2 inhibitor, has a protective role against sunitinib (SNT)-induced cardiac dysfunction in a mouse model.…”

DataSheet_1_The neutrophil elastase inhibitor, sivelestat, attenuates acute lung injury in patients with cardiopulmonary bypass.docx by Tuo Pan (9264234)

“…Secondly, a propensity-score matched cohort (sivelestat vs control: 50 vs 50) was performed in these 665 patients. …”

Flowchart of study population. by Yan Zeng (120271)

<i>vang-1(tm1422)</i> life span modulation depends on Insulin/IGF-1-like signaling and leads to higher DAF-16 activity. by Sebastian J. Honnen (183696)

“…In contrast, depletion of DAF-16 by RNAi in <i>tm1422</i> (rose spotted line) and WT (purple solid line) causes a decrease of mean life span to <b>12±0.3 d</b> (n = 247*) and <b>11.9±0.2 d</b> (n = 142*), respectively (p<0.96**). …”

The <i>Citrobacter rodentium</i> type III secretion system effector EspO affects mucosal damage repair and antimicrobial responses by Cedric N. Berger (4544008)

Image3_Sodium–Glucose CoTransporter-2 Inhibitor Empagliflozin Ameliorates Sunitinib-Induced Cardiac Dysfunction via Regulation of AMPK–mTOR Signaling Pathway–Mediated Autophagy.JPE... by Changzhen Ren (10649432)

“…We aimed to determine whether empagliflozin (EMPA), an SGLT2 inhibitor, has a protective role against sunitinib (SNT)-induced cardiac dysfunction in a mouse model.…”

Pharmacokinetics of human IgG1 and IgG2 antibodies in NHPs. by Kenneth W. Walker (6518480)

“…Clearance was not statistically different between the IgG1 antibodies at the 1 mg/kg dose, but antibody A1’s clearance was significantly lowered (<i>F</i>(7, 9) = 7.69, <i>p</i> = 0.003) at the 5 mg/kg dose with decreased mean differences of 0.18 and 0.10 mL/h/kg compared to C1 and D1, respectively.…”

pSTATs in SLE patients after cytokine stimulation. by Xinfang Huang (347652)

“…<p>The MFI for the phosphorylation of STAT1 (5A), STAT3 (5B), and STAT5 (5C) in the T cells of SLE patients decreased significantly after IFNα stimulation for 15 min. …”

PrP^Sc accumulation in <i>TNFR1^−/−</i> lymph nodes requires LTβR signaling independent of <i>Prnp</i> expression. by Tracy O'Connor (143972)

“…Whereas TNFR1^−/−-Ig mLNs all harbored ≥6.1 log TCI units/g tissue, prion infectivity in TNFR1^−/−-LTβR-Ig mLNs was reduced by at least 2.5 log TCI units/g tissue. Total mRNA was isolated from spleens (J) or mesenteric lymph nodes (mLN; K) of mice from the indicated treatment groups and analyzed for Prnp expression by Real Time PCR (Mean ± S.E.M.: Spleen – WT-Ig = 100.69±6.74, WT-LTβR-Ig = 46.02±4.30, TNFR1^−/−-Ig = 48.94±0.55, and TNFR1^−/−-LTβR-Ig = 50.11±0.55; mLN – WT-Ig = 106.05±22.54, WT-LTβR-Ig = 101.69±12.88, TNFR1^−/−-Ig = 56.43±3.13, and TNFR1^−/−-LTβR-Ig = 72.35±6.65). …”

Time-course imaging result of DCE-MRI and DW-MRI. by Xiaomeng Zhang (182897)

“…<p>A) Time-courses of normalized mean K^trans values. The mean values of normalized K^trans decreased 69% for TH-302 treated mice in Hs766t tumors, decreased 46% for Mia PaCa-2 tumors and increased 5% in SU.86.86 tumors. …”

Bortezomib reduced viral load and signs of dengue pathology in C57BL/6 mice. by Milly M. Choy (790882)

“…Mean ± SEM. N = 4–5. Student’s t test, *p<0.05.</p>…”

IPC activity levels are correlated with the incidence of reproductive dormancy. by Noriyuki Ojima (5367824)

“…The means ± SEM are shown. ns, no significance, **P < 0.01, ***P < 0.001, by the one-way ANOVA post hoc Tukey’s multiple comparisons test (see <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1007434#pgen.1007434.s001" target="_blank">S1 Table</a> for numerical data). …”

ILI time-series, weighting schemes and projection targets. by Alessio Andronico (2202853)

“…For the weighting scheme v2, we used a normal distribution parameterized with the mean and the standard deviation of the observed incidence for the corresponding calendar week across the training seasons. …”

ECG analyses of urethane anaesthetized Ts65Dn adult mice revealed cardiac conduction anomalies. by Matthieu Raveau (160575)

“…Measurement of wave amplitudes in precordial leads (G) showed a large decrease of S and J waves on V1 and limited changes in V4 whereas R waves were found normal in both V1 and V4 (n = 31 and 29 for wt and Ts65Dn respectively) (Student t-test p-values: **: <i>P</i><0.01; ***: <i><u>P</u></i><0.001).…”

Loss of HP1B reduces food intake, alters body fat levels, and leads to oxidative stress resistance due to altered feeding behavior. by Benjamin B. Mills (5879504)

“…Food intake measured using a CAFÉ assay (Y-axis, decrease in food levels over an 8hr time period as measured by drop in capillary meniscus in mm) reveals lower food intake in <i>HP1b</i> mutants (<i>HP1b</i>^<i>16</i>: p = 0.0003155; <i>HP1b</i>^<i>86</i>: p = 0.0095041; Tukey’s multiple comparisons of means; n = 8 per sex and genotype). …”

Effect of ABCG2 overexpression on the expression of SLC transporter genes and MPP, glucose and glutamine transport. by Maricla Galetti (475203)

“…Fold decrease expression was determined by the ΔΔC_T method normalized to five housekeeping genes. …”

Effect of plate washing on the dissociation of ACE inhibitor from ACE. by Sergei M. Danilov (118956)

“…Data are expressed as a % of control (i.e. ACE without inhibitor) and presented as a mean of at least 3 independent experiments. …”

Kinematic Profiles of Mudskipper Pectoral Fin versus Salamander Hindlimb by Zachary Quigley (11422969)

“…Elbow/Knee (C) and wrist/ankle (D) angles were set such that a fully extended joint corresponds to 180°, with the angle decreasing as the joint flexed. …”

Cell stress, the UPR and <i>headcase</i>. by Panagiotis Giannios (10113763)

“…Error bars represent SD of means. Scale bars, 10 μm.</p>…”