Selective TASK‑1 Inhibitor with a Defined Structure–Activity Relationship Reduces Cancer Cell Proliferation and Viability by Bárbara Arévalo (4053358)

“…Mutation of seven residues to A (I118A, L122A, F125A, Q126A, L232A, I235A, and L239A) markedly decreased the F3-induced inhibition of TASK-1 channels, consistent with the molecular modeling predictions. …”

Selective TASK‑1 Inhibitor with a Defined Structure–Activity Relationship Reduces Cancer Cell Proliferation and Viability by Bárbara Arévalo (4053358)

“…Mutation of seven residues to A (I118A, L122A, F125A, Q126A, L232A, I235A, and L239A) markedly decreased the F3-induced inhibition of TASK-1 channels, consistent with the molecular modeling predictions. …”

Growth curves (A, strain AWRI R2 (A); B, strain BH8 (B); C, strain Freddo (F)) and accumulated fermentation system mass loss(D, strain A; E, strain B; F, strain F) of <i>S</i>. <i>... by Xiang-yu Sun (748032)

Increased expression of Fz5 receptor matched with a decrease in NeuN immunoreactivity at 16w. by Carlos González-Fernández (2794207)

Descriptives of the study sample, N = 451. by Orrin D. Ware (14829115)

MeV <i>M</i> mRNA quantification in cells treated with an inhibitor of RNA polymerase III. by Pierre Khalfi (7868252)

Mean plasma concentration-time profiles of paeoniflorin and paeonol after single oral administration in NC and DNBS-induced colitis rats. by Jin-Hwa Kim (101817)

Overexpression of TNFAIP9 remitted the renal inflammation caused by 5/6 Nx in C57 mice. by Ying Chen (9697)

Schematic representation of the effects of stepwise bromination of the benzene ring of benzotriazole (Bt), including interdependence of the molecular volume (A) and pK_a (B) of the products with their IC₅₀ for inhibition of protein kinase CK2α: (a) Green arrows follow sequential bromination of the central vicinal C(5)/C(6) atoms, leading to a moderate decrease of pK_a and a large decrease in IC₅₀; (b) Red arrows illustrate the lesser effects of bromination of the peripheral C(4)/C(7) atoms, resulting in a significant decrease of pK_a, with virtually no gain in inhibitory activity; (c) Black lines link products with the same number of bromine atoms, but substantially differing in pK_a and IC₅₀, culminating in the di- and tri-brominated derivatives with inhibitory activities comparable to that of TBBt. by Romualda Wąsik (119538)

Mean observer DCCR (%) and DDR (%) at C5-6 in neutral, flexed and extended neck positions in horses that were not operated (n = 16) versus operated (n = 6) at this site. by Devon England (21262225)

Mean observer DCCR (%) and DDR (%) at C4-5 in neutral, flexed and extended neck positions in horses that were not operated (n = 10) versus operated (n = 12) at this site. by Devon England (21262225)

Overexpression of TNFAIP9 counteracted the renal damage caused by 5/6 Nx in C57 mice. by Ying Chen (9697)

Effects of specific anti-miRs for the five miRNAss on the IC50 of cisplatin (A) and paclitaxel (B) in Hec1A cells. by Taek Sang Lee (494682)

Ulk2 morphants have a decreased extension/retraction ratio. by Stacey Lee (647217)

Changes in neural activity were decreased in animals pre-exposed to 5-HT and <i>mod-1</i> mutants when the worms switched their locomotive direction. by Haruka Mori (8082215)

“…(F) Decreasing levels of RID neural activity during the transition periods from forward to backward locomotion in mock, 5-HT pre-exposed (p = 1.3 × 10⁻³), and <i>mod-1</i> mutant (p = 5.4 × 10⁻⁴) animals. …”

Temporal distributions of inscriptions and occupations using uniform 50-years-long timeblocks. by Vojtěch Kaše (6156971)

Retigabine and ML213 decrease the constriction tone of human detrusor strips. by Julie Svalø (693320)

“…<p>(A) The original DSM tension recordings illustrate the relaxatory effect of retigabine and ML213, which are K_v7.2–7.5 and K_v7.2/7.4/7.5 channel activators, respectively. …”

Fig 5 - by Mary J. Obayemi (11813022)

Development of a cAMP sensor with decreased pH sensitivity. by Katy L. Everett (461878)

Mean absolute SHAP values of the most important predictors for APM_MN in each of the five folds of the first repeat. by Shubhayu Bhattacharyay (11242977)