Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Syn... by Carlos Roca (4069366)

“…Recently, the phenothiazine FD44 has been identified as an inhibitor of this PPI, decreasing the abnormally high synapse number and enhancing associative learning in a FXS animal model. …”

Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Syn... by Carlos Roca (4069366)

“…Recently, the phenothiazine FD44 has been identified as an inhibitor of this PPI, decreasing the abnormally high synapse number and enhancing associative learning in a FXS animal model. …”

Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Syn... by Carlos Roca (4069366)

“…Recently, the phenothiazine FD44 has been identified as an inhibitor of this PPI, decreasing the abnormally high synapse number and enhancing associative learning in a FXS animal model. …”

Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Syn... by Carlos Roca (4069366)

“…Recently, the phenothiazine FD44 has been identified as an inhibitor of this PPI, decreasing the abnormally high synapse number and enhancing associative learning in a FXS animal model. …”

Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Syn... by Carlos Roca (4069366)

“…Recently, the phenothiazine FD44 has been identified as an inhibitor of this PPI, decreasing the abnormally high synapse number and enhancing associative learning in a FXS animal model. …”

Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Syn... by Carlos Roca (4069366)

“…Recently, the phenothiazine FD44 has been identified as an inhibitor of this PPI, decreasing the abnormally high synapse number and enhancing associative learning in a FXS animal model. …”

Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Syn... by Carlos Roca (4069366)

“…Recently, the phenothiazine FD44 has been identified as an inhibitor of this PPI, decreasing the abnormally high synapse number and enhancing associative learning in a FXS animal model. …”

Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Syn... by Carlos Roca (4069366)

“…Recently, the phenothiazine FD44 has been identified as an inhibitor of this PPI, decreasing the abnormally high synapse number and enhancing associative learning in a FXS animal model. …”

Increased hydrophilic plasma bile acids are correlated with protection from adiposity in skin-specific stearoyl-CoA desaturase-1 deficient mice by Sabrina N. Dumas (5474456)

“…<div><p>Stearoyl-CoA desaturase 1 (SCD1) catalyzes the rate limiting step in monounsaturated fatty acid synthesis by inserting a double bond at the delta-9 position of long-chain fatty acids. …”

Molecular Wires using (Oligo)pyrroles as Connecting Units: An Electron Transfer Study by Ulrike Pfaff (1580383)

“…The cyclic voltammetry data reveal that the splitting of the ferrocene-based redox couples, Δ<i>E</i>°′, decreases with increasing oligopyrrole chain length and, hence, a greater metal–metal distance. …”

Reprogramming pancreatic stellate cells via p53 activation: A putative target for pancreatic cancer therapy by Maya Saison-Ridinger (4666732)

“…<i>In vivo</i>, treatment of tumor-bearing mice with the clinical form of Nutlin-3a induces stromal p53 activation, reverses caPSCs activation, and decreases fibrosis. …”

BrdU staining of acinar cells, islet cells in duodenal area and ductule-like cells in foci area of sham rat and 90% PX rat. by Shigenori Ota (3389546)

“…<p>5 rats in each sham and 90% PX group were sacrificed in this experiment. (A) Representative immuno-staining images of acinar cells for BrdU in duodenal area of sham rat (upper panel), 90% PX rat at day3 (middle panel) and 90% PX rat at day 5 (lower panel). …”

Cyclosporine A eyedrops with self-nanoemulsifying drug delivery systems have improved physicochemical properties and efficacy against dry eye disease in a murine dry eye model by Seung Pil Bang (7878623)

“…Aqueous tear volume and fluorescein staining scores were improved in C-CsA- and SNEDDS-treated mice. Numbers of PAS-positive goblet cells and levels of inflammatory mediators were decreased by both C-CsA and SNEDDS, although SNEDDS resolved inflammation more effectively than C-CsA.…”

Effect of treatment with VA-lip siRNA HSP47 on BrdU uptake and HSP47 expression in islet of duodenal area. by Shigenori Ota (3389546)

“…<p>Quantification of BrdU uptake rate was carried out as described in the legend of <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0165747#pone.0165747.g003" target="_blank">Fig 3</a>. …”

miR-19 targets PTEN and mediates high mobility group protein B1(HMGB1)-induced proliferation and migration of human airway smooth muscle cells by Changchun Hou (2634661)

“…Functional studies indicated that overexpression of miR-19a enhanced the proliferation and migration of ASM cells, whereas inhibition of miR-19a decreased the proliferation and migration of ASM cells. …”

Growth of certain cancer cell lines requires IRE1 but not its enzymatic activity. by Iratxe Zuazo-Gaztelu (21071939)

The association between consistent habitual running or walking and a slow trajectory of estimated GFR decline (quartile 1)^b'*'. by Ronit Calderon-Margalit (584756)

AKT regulates UGCG expression via epigenomic alterations. by Mohammad Nafees Ansari (22232505)

“…(<b>D</b>) Results from qRT-PCR (mean ± SEM, <i>n</i> = 4) show a decrease in <i>UGCG</i> expression in MCF-7_ZFX^OE cells on AKT inhibition by MK2206. …”

Influence of point mutations on [³H]-RTX binding. by Katsuya Ohbuchi (559460)

“…Non-specific binding was evaluated in the presence of 1 μM RTX. For Y511A, F587A, F591A and L670A, specific binding of [³H]-RTX was lost or decreased. …”

Related to Fig 4. by Mohammad Nafees Ansari (22232505)

“…(<b>C</b>) Results from qRT-PCR (mean ± SEM, <i>n</i> = 4) show a decrease in <i>UGCG</i> expression in BT-474_ZFX^OE cells on AKT inhibition by MK2206 (4 μM). …”