Design and Discovery of Novel Cyclic Peptides as EDPs–EBP Interaction Inhibitors for the Treatment of Liver Fibrosis by Nazi Song (6112304)

“…The subsequent in vivo study demonstrated that <b>C</b>_<b>XJ</b><b>-2</b> possessed potent antifibrotic efficacy in ameliorating CCl₄-induced liver fibrosis. This work provides a successful pharmacological strategy for the development of novel inhibitors of EDPs–EBP interaction, which sheds new light on how cyclic peptides disrupt peptide–protein interaction and may also provide new structure-oriented therapeutic candidates in liver fibrosis.…”

Data_Sheet_1_Age- and Sex-Related Topological Organization of Human Brain Functional Networks and Their Relationship to Cognition.xlsx by Heidi Foo (11849567)

Data Sheet 4_Novel idebenone derivatives attenuated oxidative stress injury and myocardial damage.zip by Yuwei Peng (17203933)

“…Our results demonstrated that IDE derivatives could be a new research direction for the treatment of cardiovascular diseases associated with oxidative stress.…”

Reinforcement learning parameters and model-independent performance indices improve over runs. by Monja P. Neuser (4500289)

“…<p><b>a.</b> Learning rate for wins, α_win, does not change over runs <i>(b = -0</i>.…”

Data_Sheet_6_Sestrin2-Mediated Autophagy Contributes to Drug Resistance via Endoplasmic Reticulum Stress in Human Osteosarcoma.ZIP by Zhen Tang (2977569)

“…Therefore, our results explain one underlying mechanism of increasing the sensitivity of osteosarcoma to chemotherapy and suggest that Sestrin2 is a promising gene target.</p>…”

Effects of Parkia platycephala on feeding behavior, rumen health, blood markers, and physiological responses of lactating goats by Ianete Lima Batista (10446651)

“…At these replacement levels, the goats significantly spent more time feeding and ruminating. There was a significant decrease in the number of chews (number/day and number/min) with an increase in PP inclusion. …”

Table 2_Rhodiola crenulata polysaccharide alleviates dextran sulfate sodium-induced ulcerative colitis in mice by repairing the intestinal barrier and regulating the intestinal mic... by Jia Lv (431990)

“…The monosaccharide composition of RCP (Mw = 67.848 kDa) includes mannose, rhamnose, glucuronic acid, galacturonic acid, glucose, galactose, and arabinose, with a molar ratio of 0.22:1:0.07:7.03:2.88:0.64:4.12. …”

Table_1_Postpartum depression during the COVID-19 pandemic: an umbrella review and meta-analyses.docx by Ali Sahebi (11701730)

“…The searches were conducted without a time limit until the end of May 2023. Meta-analysis was performed using the random effects model, heterogeneity was assessed using the I2 index, and publication bias was evaluated using Begg’s test. …”

Data_Sheet_2_Sestrin2-Mediated Autophagy Contributes to Drug Resistance via Endoplasmic Reticulum Stress in Human Osteosarcoma.ZIP by Zhen Tang (2977569)

“…Therefore, our results explain one underlying mechanism of increasing the sensitivity of osteosarcoma to chemotherapy and suggest that Sestrin2 is a promising gene target.</p>…”

Diagram of the freezing front. by Hang Mu (133804)

“…Additionally, under alternating hot and cold cycles, a temperature lag occures at the lower sensors. …”

Carbosiloxane Bottlebrush Networks for Enhanced Performance and Recyclability by Taejun Eom (17300332)

“…The recovered monomer was successfully repolymerized through anionic ring-opening polymerization with no decrease in structural fidelity or activity. In summary, this combination of unique (macro)monomer design and bottlebrush architecture creates new opportunities in sustainable practices by offering a robust, recyclable alternative to commercial silicone-based materials.…”

Glial fibrillary acid protein (GFAP)-positive Müller glial cells (MCGs) in resveratrol (RSV)-treated choroidal neovascularization (CNV)-induced eyes. by Tomoka Ishida (4394335)

“…<p>Activated MGCs were labeled with anti-GFAP antibody (×200). (A and B) On day 1, GFAP-positive MGCs were not present. …”

Image_5_Sestrin2-Mediated Autophagy Contributes to Drug Resistance via Endoplasmic Reticulum Stress in Human Osteosarcoma.TIF by Zhen Tang (2977569)

“…Therefore, our results explain one underlying mechanism of increasing the sensitivity of osteosarcoma to chemotherapy and suggest that Sestrin2 is a promising gene target.</p>…”

Table_3_The Aging Features of Thyrotoxicosis Mice: Malnutrition, Immunosenescence and Lipotoxicity.xlsx by Qin Feng (147009)

“…The results of routine blood tests and flow cytometry showed that immunosenescence occurred in thyrotoxicosis mice, which was characterized by a significant decrease in neutrophils, lymphocytes, CD4+/CD8+ and CD4+IFN-γ+ lymphocytes. …”

DataSheet_2_Erwinia asparaginase (crisantaspase) increases plasma levels of serine and glycine.pdf by Dominique Bollino (14245121)

“…In addition to the expected decrease of plasma glutamine and asparagine, we observed a significant increase in plasma serine and glycine post-crisantaspase. …”

DataSheet1_Yangjing capsule improves oligoasthenozoospermia by promoting nitric oxide production through PLCγ1/AKT/eNOS pathway.docx by Weimin Deng (613914)

“…Yangjing capsule (YC), a traditional Chinese preparation, displays beneficial effects on male infertility. …”

Table_1_Metabolomics and Microbiomics Reveal Impacts of Rhizosphere Metabolites on Alfalfa Continuous Cropping.xls by Ruiting Wang (6830171)

“…<p>Alfalfa long-term continuous cropping (CC) can pose a serious threat to alfalfa production. However, the mechanism of alfalfa CC obstacle is unclear as of today. …”

Data_Sheet_1_Transcriptomics and Metabolomics Changes Triggered by Inflorescence Removal in Panax notoginseng (Burk.).docx by Yu Bai (258833)

“….), in which saponins are the major active components, is a famous traditional Chinese medicine used to stop bleeding and to decrease inflammation and heart disease. …”

Geography, Trajectories, and Controls of Coastal Water Quality: More Rapid Improvement in the Shallow Zone of the Chesapeake Bay by Qian Zhang (49333)

“…In addition, the attainment trajectory has been affected by mainly external drivers (i.e., nutrient reductions) and, to a lesser extent, internal drivers (i.e., water temperature and stratification). …”

Table_2_Lactitol Supplementation Modulates Intestinal Microbiome in Liver Cirrhotic Patients.XLSX by Haifeng Lu (465603)

“…<p>Background: Cirrhosis is a common chronic liver disease characterized by irreversible diffuse liver damage. …”