Endothelin-1 Inhibits Prolyl Hydroxylase Domain 2 to Activate Hypoxia-Inducible Factor-1α in Melanoma Cells by Francesca Spinella (247034)

“…<div><h3>Background</h3><p>The endothelin B receptor (ET_BR) promotes tumorigenesis and melanoma progression through activation by endothelin (ET)-1, thus representing a promising therapeutic target. The stability of hypoxia-inducible factor (HIF)-1α is essential for melanomagenesis and progression, and is controlled by site-specific hydroxylation carried out by HIF-prolyl hydroxylase domain (PHD) and subsequent proteosomal degradation.…”

Image_1_Dietary α-Linolenic Acid-Rich Flaxseed Oil Exerts Beneficial Effects on Polycystic Ovary Syndrome Through Sex Steroid Hormones—Microbiota—Inflammation Axis in Rats.JPEG... by Ting Wang (16292)

“…A decrease in plasma lipopolysaccharide level and an increase in short-chain fatty acids, including acetic acid, propionic acid, butyric acid and pentanoic acid, were determined after dietary FO supplementation. …”

Table_3_Genes related to osmoregulation and antioxidation play important roles in the response of Trollius chinensis seedlings to saline-alkali stress.docx by Rongmiao Hou (14507159)

“…<p>Saline-alkali stress is one of the main abiotic stress factors affecting plant growth and development. Trollius chinensis is a perennial herbal medicinal plant with high values for garden application. …”

Analysis of 13,312 benthic invertebrate samples from German streams reveals minor deviations in ecological status class between abundance and presence/absence data by Dominik Buchner (8173911)

“…DNA-based tools, such as DNA metabarcoding, provide a new and precise method for species identification but cannot deliver robust abundance data. …”

Characterizing suboptimal child passenger safety practices in crashes with fatalities: Child, driver, vehicle, neighborhood, and policy factors by Arthi S. Kozhumam (14176683)

“…The strongest predictors of suboptimal practices were child age 4-7 years (OR 1.10, 95% CI 1.09-1.12) vs. <4 years and vehicle over capacity (OR 1.09, 95% CI 1.06-1.11). There was a decrease in suboptimal child passenger safety practices with increasing vehicle model year, COI level, fines, and law scores. …”

Image2_Peroxisomal Proliferator-Activated Receptor β/δ Deficiency Induces Cognitive Alterations.TIFF by Triana Espinosa-Jiménez (12504080)

“…Different techniques, such as GolgiStain kit or immunofluorescence, were used to evaluate the role of PPARβ/δ in memory dysfunction. Our results showed a decrease in dendritic spine density and synaptic markers in PPARβ/δ^-/- mice, which were corroborated in the NORT. …”

Competitive tuning: Competition's role in setting the frequency-dependence of Ca²⁺-dependent proteins by Daniel R. Romano (4574287)

“…Normally, proteins form networks that when activated produce persistent changes in a synapse’s molecular composition. In hippocampal neurons, calcium ion (Ca²⁺) flux through N-methyl-D-aspartate (NMDA) receptors activates Ca²⁺/calmodulin signal transduction networks that either increase or decrease the strength of the neuronal synapse, phenomena known as long-term potentiation (LTP) or long-term depression (LTD), respectively. …”

Data_Sheet_1_Initial Experience of Challenge-Free MRI-Based Oxygen Extraction Fraction Mapping of Ischemic Stroke at Various Stages: Comparison With Perfusion and Diffusion Mapping... by Shun Zhang (334141)

“…The OEF value of infarct core showed a trend of decrease from acute, to early subacute, and to late subacute stages of ischemic stroke. …”

Image_1_Immunosuppression Has Long-Lasting Effects on Circulating Follicular Regulatory T Cells in Kidney Transplant Recipients.TIF by Qian Niu (425660)

“…A history of alemtuzumab therapy did lead to a significant decrease in cTfr cells of 85.8% (median) compared with patients not treated with anti-rejection therapy (p < 0.0001). …”

DataSheet1_Biomass burning-agriculture coupling in the Orinoco savannas—Particulate matter emission scenarios.PDF by Rodrigo Jimenez (10999161)

“…<p>The Colombian Orinoco savannas (254 thousand km²), also known as Orinoquia or Llanos, have been steadily transformed into pastures for more than a century, and since the 1990s, into commodity crop intensified production. …”

Image_3_Dietary α-Linolenic Acid-Rich Flaxseed Oil Exerts Beneficial Effects on Polycystic Ovary Syndrome Through Sex Steroid Hormones—Microbiota—Inflammation Axis in Rats.JPEG... by Ting Wang (16292)

“…A decrease in plasma lipopolysaccharide level and an increase in short-chain fatty acids, including acetic acid, propionic acid, butyric acid and pentanoic acid, were determined after dietary FO supplementation. …”

MG-132 enhanced apoptosis induction and caspase-8 cleavage due to DX1 treatment in HL-60 cells. by Zhiying Yu (356965)

“…<p>(<b>A</b>) <b>Western blot analysis of PARP, caspase-8 and c-FLIP levels in HL-60 cells treated with MG-132.…”

Data_Sheet_2_Identification of Quantitative Trait Loci Associated With Iron Deficiency Tolerance in Maize.xlsx by Jianqin Xu (833917)

“…Compared with N1, N2 resulted in a 70.0% decrease of the root Fe concentration for Wu312 in the −Fe treatment, N2 treatment reduced the root Fe concentration of Ye478 by 55.8% in the −Fe treatment. …”

DataSheet1_Modified Baihu decoction therapeutically remodels gut microbiota to inhibit acute gouty arthritis.PDF by Xianyang Wang (2349529)

“…While the relative abundance of Lactobacillaceae, Erysipelotrichaceae, Ruminococcaceae, Prevotellaceae and Enterobacteriaceae showed a relative decrease in species abundance. Of these, the reduction in species abundance of Enterobacteriaceae was associated with a reduction in amino acid metabolism and environmental perception. …”

Cell-intrinsic sphingosine kinase 2 promotes macrophage polarization and renal inflammation in response to unilateral ureteral obstruction by Mallika Ghosh (742901)

“…These results demonstrate that reducing Sphk2 activity by genetic or pharmacological manipulation markedly decreases inflammatory and fibrotic responses to obstruction, resulting in diminished renal injury and supporting Sphk2 as a novel driver of the pro-inflammatory macrophage phenotype.…”

Prediction of Retention Time and Collision Cross Section (CCS_H+, CCS_H–, and CCS_Na+) of Emerging Contaminants Using Multiple Adaptive Regression Spl... by Alberto Celma (4092583)

“…Multivariate and univariate models were evaluated showing a better fit for univariate models to the experimental data. …”

Table_1_Supplemental Xylooligosaccharide Modulates Intestinal Mucosal Barrier and Cecal Microbiota in Laying Hens Fed Oxidized Fish Oil.DOCX by Jian-min Zhou (10175516)

“…The abundance of Erysipelatoclostridium decreased by XOS addition was negatively associated with ileal VH, VCR, ileal mucosal sIgA content, and the relative expression of zonula occludens-2, CLDN1, and CLDN5. …”

Exploiting Co-Benefits of Increased Rice Production and Reduced Greenhouse Gas Emission through Optimized Crop and Soil Management by Ning An (618997)

“…Advances in nitrogen, water and crop management (Best Management Practices—BMPs) helped closing existing yield gaps and resulted in a substantial reduction in CO₂-equivalent emission of rice farming despite a tradeoff of increase N₂O emission. …”

Epigenetic regulatory genes as putative cancer amplified driver genes. by Ying Chen (9697)

“…(B) <i>BRD4</i> and <i>YEATS4</i> shRNA activity in a panel of cancer cell lines (Project Achilles). shRNA score denotes the log2 based decrease in the representative shRNA compared to pooled shRNA in cancer cell lines after several rounds of proliferation post-shRNA <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0098293#pone.0098293-Cheung1" target="_blank">[11]</a>. …”

Table_4_Long Non-coding RNAs Rian and Miat Mediate Myofibroblast Formation in Kidney Fibrosis.xlsx by Roel Bijkerk (4662769)

“…In order to identify pericyte long non-coding RNAs (lncRNAs) that could serve as a target to decrease myofibroblast formation and counteract the progression of kidney fibrosis we employed two models of experimental kidney injury, one focused on kidney fibrosis (unilateral ureteral obstruction; UUO), and one focused on acute kidney injury that yields kidney fibrosis in the longer term (unilateral ischemia-reperfusion injury; IRI). …”