Data_Sheet_1_TLR4-Dependent DUOX2 Activation Triggered Oxidative Stress and Promoted HMGB1 Release in Dry Eye.PDF by Bowen Wang (526637)

“…Interestingly, after ablated DUOX2 expression by siRNA, we found a remarkable decrease of ROS level and recovered MMP in HCE cells. …”

Table 2_Global burden of low back pain attributable to smoking in 204 countries and territories in 1990–2021.xls by Baodong Wang (3359171)

“…Background<p>Smoking has a major influence on the development and worsening of low back pain (LBP). …”

Table_1_Reactive oxygen species-responsive supramolecular deucravacitinib self-assembly polymer micelles alleviate psoriatic skin inflammation by reducing mitochondrial oxidative s... by Leiqing Yao (18533049)

“…Car@Deu@PEPS inhibited STAT3 signaling cascade with a corresponding decrease in the levels of the differentiation and proliferative markers Keratin 17 and Cyclin D1, respectively. …”

Image_4_Dual Effect of Bleomycin on Histopathological Features of Lungs and Mediastinal Fat-Associated Lymphoid Clusters in an Autoimmune Disease Mouse Model.tif by Yaser Hosny Ali Elewa (5130725)

“…<p>Mediastinal fat-associated lymphoid clusters (MFALCs) are novel immune clusters that function in the pathogenesis of bleomycin (BLM)-induced pneumonitis in a C57BL/6 mouse model. However, we lack literature on the effects of BLM in an autoimmune disease mouse model (AIDM). …”

Differential Expression of microRNAs in <i>Francisella tularensis</i>-Infected Human Macrophages: miR-155-Dependent Downregulation of MyD88 Inhibits the Inflammatory Response by Sarmistha Bandyopadhyay (641461)

“…<div><p><i>Francisella tularensis</i> is a Gram-negative, facultative intracellular pathogen that replicates in the cytosol of macrophages and is the causative agent of the potentially fatal disease tularemia. …”

DataSheet_1_Cytopenia after chimeric antigen receptor T cell immunotherapy in relapsed or refractory lymphoma.docx by Jin Zhou (90734)

“…However, this treatment is linked to a high frequency of adverse events (AEs), such as cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS), and hematologic toxicity. …”

Image_5_Pharmacological Disruption of Phosphorylated Eukaryotic Initiation Factor-2α/Activating Transcription Factor 4/Indian Hedgehog Protects Intervertebral Disc Degeneration via... by Junping Bao (10931142)

“…On the contrary, further activating p-eIF2α aggravated the NP cell degeneration, with amplification of ATF4/Ihh and a higher level of ROS and apoptosis. Additionally, applying cyclopamine (CPE) to suppress Ihh was efficient to prevent NP cell apoptosis but did not decrease the ROS level. …”

Immune Checkpoint Inhibitors and Risk of Type 1 Diabetes by Xuan Chen (158617)

“…<b>Background:</b> Type 1 diabetes mellitus (T1DM) is a rare, irreversible immune-related adverse event reported in patients receiving treatment with immune-checkpoint inhibitors (ICI). …”

Data Sheet 1_Global, regional and national burden of neck pain in children and adolescents: GBD 2021 systematic analysis.pdf by Chao Sun (139686)

“…The global incidence of NP among children and adolescents increased from 3.17 million cases in 1990 to 3.82 million in 2021, while the age-standardized incidence rate showed a minimal decrease (AAPC −0.02%). The burden of NP in terms of YLDs increased from 0.89 million in 1990 to 1.08 million in 2021, although the age-standardized YLD rate remained stable (AAPC 0%). …”

Table3_Revealing the Mechanism of Huazhi Rougan Granule in the Treatment of Nonalcoholic Fatty Liver Through Intestinal Flora Based on 16S rRNA, Metagenomic Sequencing and Network... by Yingying Liu (360782)

“…Analysis of intestinal flora showed that HRG changed the composition of intestinal flora, which was characterized by a decrease in the Firmicutes/Bacteroidetes ratio. …”

DataSheet_3_Anti-Rheumatic Properties of Gentiopicroside Are Associated With Suppression of ROS-NF-κB-NLRP3 Axis in Fibroblast-Like Synoviocytes and NF-κB Pathway in Adjuvant-Induc... by Meiling Wang (808623)

“…Consistent with such suppression, Gent led to a significant decrease in IL-1β secretion by treated cells. …”

Image_6_Automated quantification of photoreceptor outer segments in developing and degenerating retinas on microscopy images across scales.TIFF by Suse Seidemann (18608065)

“…The assessments showed an increase in POS number, volume, and membrane coherency during wild-type postnatal development, while a decrease in all three observables was detected in different retinal degeneration mouse models. …”

Table_2_Impaired Cytotoxic Response in PBMCs From Patients With COVID-19 Admitted to the ICU: Biomarkers to Predict Disease Severity.docx by Lorena Vigón (7325558)

“…<p>Infection by novel coronavirus SARS-CoV-2 causes different presentations of COVID-19 and some patients may progress to a critical, fatal form of the disease that requires their admission to ICU and invasive mechanical ventilation. …”

Image 1_Screening of LAB strains and their co-culture fermentation with Bacillus subtilis of Cili fruit substrate: impact on γ-aminobutyric acid enrichment, key enzyme activities,... by Angelo Uriho (20992232)

“…Compared to B. subtilis fermented substrate (Bs), a significant decrease in pH (4.89, except BsLf), increase in TTA (19.30–29.20 mL) was observed after co-culture fermentation of Cili fruit. …”

Image_3_Automated quantification of photoreceptor outer segments in developing and degenerating retinas on microscopy images across scales.TIFF by Suse Seidemann (18608065)

“…The assessments showed an increase in POS number, volume, and membrane coherency during wild-type postnatal development, while a decrease in all three observables was detected in different retinal degeneration mouse models. …”

CONSORT flow chart of included patients. by Zhiwei Li (131853)

“…Furthermore, PCV-VG was associated with an increased center of ventilation (45.1 ± 3.7 vs. 41.7 ± 3.5, P < 0.05), a decrease in global inhomogeneity (GI) (0.85 ± 0.16 vs. 1.06 ± 0.30, P < 0.05), and a reduction in regional ventilation delay index (RVDI) (10.5 ± 4.5 vs. 15.9 ± 5.3, P < 0.05), when compared to VCV. …”

Table 4_The burden and etiologies of diarrhea in Asia and its countries from 1990 to 2021 and the forecast to 2040: analyses informed by the global burden of disease study 2021.doc... by Shan Liu (193759)

“…Based on the BAPC model analysis, the ASIR and the age-standardized prevalence rate of diarrhea in Asia are predicted to decrease initially and then increase. The age-standardized DALY rate (ASDR) and the age-standardized mortality rate (ASMR) of diarrhea in Asia are predicted to demonstrate a consistent declining trend. …”

Image_2_Genetic Diversity in the Italian Holstein Dairy Cattle Based on Pedigree and SNP Data Prior and After Genomic Selection.TIF by Michela Ablondi (7402970)

“…The pattern of the effective population size based on pedigree and SNP data was similar although different in scale, with a constant decrease within the last five generations. …”

Image 3_Clinical isolates of Providencia rettgeri and Providencia Stuartii evades neutrophil-mediated killing by subverting neutrophil-extracellular traps.tif by Joselyn E. Castro (22355326)

“…This decrease was abolished by fixed bacteria, and was dependent on the release of a DNase activity. …”

Differentially Expressed Plasma MicroRNAs and the Potential Regulatory Function of Let-7b in Chronic Thromboembolic Pulmonary Hypertension by Lijuan Guo (404771)

“…The results showed that 1) thirty five microRNAs were differentially expressed in CTEPH patients, among which, a signature of 17 microRNAs, which was shown to be related to the disease pathogenesis by <i>in silico</i> analysis, gave diagnostic efficacy of both sensitivity and specificity >0.9. 2) Let-7b, one of the down-regulated anti-oncogenic microRNAs in the signature, was validated to decrease to about 0.25 fold in CTEPH patients. 3) ET-1 and TGFBR1 were direct targets of let-7b. …”