Table_1_Empagliflozin suppresses mitochondrial reactive oxygen species generation and mitigates the inducibility of atrial fibrillation in diabetic rats.DOCX by Takuya Koizumi (2667574)

“…We aimed to further investigate this, and examine whether the SGLT2-i empagliflozin suppresses mitochondrial-ROS generation and mitigates fibrosis.</p>Methods<p>A high-fat diet and low-dose streptozotocin treatment were used to induce type-2 DM (T2DM) in Sprague-Dawley rats. …”

image2_Microbial Metabolite Sodium Butyrate Attenuates Cartilage Degradation by Restoring Impaired Autophagy and Autophagic Flux in Osteoarthritis Development.tif by Haikang Zhou (10575770)

“…<p>Osteoarthritis (OA) is a degenerative joint disease with multiple etiologies that affects individuals worldwide. …”

Table_1_Densification of the Ground-Based GNSS Observation Network in the Southwest Indian Ocean: Current Status, Perspectives, and Examples of Applications in Meteorology and Geod... by Olivier Bousquet (9342110)

“…At the seasonal scale, maximum IWV values are similar everywhere, minimum values decrease away from the equator and a sharp IWV gradient can be noticed during the wet–dry transition period. …”

Table_2_The Food Additive β-Caryophyllene Exerts Its Neuroprotective Effects Through the JAK2-STAT3-BACE1 Pathway.xlsx by Yujia Zhang (757462)

“…The cell morphology altered dramatically 72 h after transfection, becoming rounder, with a decrease in cell number. BCP exhibited the potential to dramatically increase PC-12 cell viability while protecting cell morphology. …”

Image_1_Pharmacological Disruption of Phosphorylated Eukaryotic Initiation Factor-2α/Activating Transcription Factor 4/Indian Hedgehog Protects Intervertebral Disc Degeneration via... by Junping Bao (10931142)

“…On the contrary, further activating p-eIF2α aggravated the NP cell degeneration, with amplification of ATF4/Ihh and a higher level of ROS and apoptosis. Additionally, applying cyclopamine (CPE) to suppress Ihh was efficient to prevent NP cell apoptosis but did not decrease the ROS level. …”

Targeted release of stromal cell-derived factor-1α by reactive oxygen species-sensitive nanoparticles results in bone marrow stromal cell chemotaxis and homing, and repair of vascu... by Fang He (43884)

“…This repair is achieved mainly via stromal cell-derived factor (SDF)-1α promoting the mobilization, chemotaxis, homing, and targeted differentiation of bone marrow mesenchymal stem cells (BMSCs) into endothelial cells. Forming a concentration gradient from the site of local damage in the circulation is essential to the role of SDF-1α. …”

Effect of Roux-en-Y Gastric Bypass on the NLRP3 Inflammasome in Adipose Tissue from Obese Rats by Andreea Oana Mocanu (803403)

“…These changes in gene expression were accompanied by a decrease in NLRP3, ASC, IL–18, caspase–1 and IL–1β protein expression in omental tissue. …”

Data_Sheet_2_Where does the time go? Temporal patterns of pumping behaviors in mothers of very preterm infants vary by sociodemographic and clinical factors.PDF by Aloka L. Patel (17549421)

“…After accounting for mothers who stopped pumping, there was a gradual decrease in daily pumping minutes between postpartum weeks 2 (89 min) and 10 (46 min). …”

Bak Compensated for Bax in p53-null Cells to Release Cytochrome c for the Initiation of Mitochondrial Signaling during Withanolide D-Induced Apoptosis by Susmita Mondal (174649)

“…<div><p>The goal of cancer chemotherapy to induce multi-directional apoptosis as targeting a single pathway is unable to decrease all the downstream effect arises from crosstalk. …”

RNAi knockdown of pex3 reduces peroxisome numbers and impairs viability. by Joseph E. Faust (580247)

“…<p>(<b>A</b>) A schematic of the pex3 genomic region shows the area targeted by the inverted repeat. …”

Induction of Heme Oxygenase-1 Can Halt and Even Reverse Renal Tubule-Interstitial Fibrosis by Matheus Correa-Costa (119464)

“…Heme-oxygenase-1 (HO-1) is a cytoprotective molecule that has been shown to be beneficial in various models of renal injury. …”

Image_1_Biocontrol potential of wine yeasts against four grape phytopathogenic fungi disclosed by time-course monitoring of inhibitory activities.pdf by Marcos Esteves (14727904)

“…More notably, the approach used allowed the detection of a wide array of yeast-induced mold response profiles encompassing, besides the decrease of mold growth, the inhibition or delay of spore germination and the complete arrest of mycelial extension, and even its stimulation at different phases. …”

Data_Sheet_1_Adiponectin Mediates the Protection of H2S Against Chronic Restraint Stress-Induced Cognitive Impairment via Attenuating Hippocampal Damage.ZIP by Qiong-Yan Tang (10748115)

“…In addition, Anti-Acrp30 blocked the protective effect of NaHS on hippocampal apoptosis in rats-subjected with CRS as evidenced by the pathological changes in hippocampus tissues in hematoxylin and eosin (HE) staining and the increases in the amount of the condensed and stained to yellowish-brown or brownish yellow neuron nucleuses in terminal deoxynucleotidyl transferase transfer-mediated dUTP nick end-labeling (TUNEL) staining as well as the expression of hippocampal pro-apoptotic protein (Bax), and a decrease in the expression of hippocampal anti-apoptotic protein (Bcl-2). …”

DataSheet_1_Evaluating the Microsatellite Instability of Colorectal Cancer Based on Multimodal Deep Learning Integrating Histopathological and Molecular Data.csv by Wenjing Qiu (315272)

“…However, traditional wet-lab experiment-based MSI detection is time-consuming and relies on experimental conditions. In addition, a comprehensive study on the associations between MSI status and various molecules like mRNA and miRNA has not been performed. …”

Image_2_Automated quantification of photoreceptor outer segments in developing and degenerating retinas on microscopy images across scales.tiff by Suse Seidemann (18608065)

“…The assessments showed an increase in POS number, volume, and membrane coherency during wild-type postnatal development, while a decrease in all three observables was detected in different retinal degeneration mouse models. …”

Image_5_Automated quantification of photoreceptor outer segments in developing and degenerating retinas on microscopy images across scales.TIFF by Suse Seidemann (18608065)

“…The assessments showed an increase in POS number, volume, and membrane coherency during wild-type postnatal development, while a decrease in all three observables was detected in different retinal degeneration mouse models. …”

Data_Sheet_1_Stroke Admissions, Stroke Severity, and Treatment Rates in Urban and Rural Areas During the COVID-19 Pandemic.DOCX by Hebun Erdur (4858576)

“…<p>Background: Many regions worldwide reported a decline of stroke admissions during the early phase of the coronavirus disease 2019 (COVID-19) pandemic. …”

GPR40 partial agonist MK-2305 lower fasting glucose in the Goto Kakizaki rat via suppression of endogenous glucose production by Corin Miller (4042664)

“…The decrease in EGP was not likely due to a direct effect on the liver, as isolated perfused liver studies showed no effect of MK-2305 <i>ex vivo</i> and GPR40 is not expressed in the liver. …”

<i>In vitro</i> and <i>in vivo</i> Bioactivity of Stomoxyn. by Erick O. Awuoche (4603582)

“…</b> Gene-silencing validation: The relative expression of <i>stomoxyn</i> was measured from dsGFP and dsStomoxyn<i>-</i>treated <i>Gff</i> flies, showing a significant decrease in expression (<i>p</i><0.0001) in the case of dsStomoxyn<i>-</i>treated group. …”

Raw experimental data Fig 3. by Feline F. W. Benavides (13694053)

“…Additionally, we detected increased microglial activation in the olfactory bulb and hippocampus, and a decrease in the astrocytic activation status in the white matter and hippocampus of SARS-CoV-2 inoculated ferrets. …”