Dynorphin Neuropeptides Decrease Apparent Proton Affinity of ASIC1a by Occluding the Acidic Pocket by Lilia Leisle (11356934)

“…We confirmed experimentally that the interaction is predominantly driven by electrostatic forces, and using noncanonical amino acids as photo-cross-linkers, we identified 16 residues in ASIC1a contributing to Big Dyn binding. Covalently tethering Big Dyn to its ASIC1a binding site dramatically decreased the proton sensitivity of channel activation, suggesting that Big Dyn stabilizes a resting conformation of ASIC1a and dissociates from its binding site during channel opening.…”

Dynorphin Neuropeptides Decrease Apparent Proton Affinity of ASIC1a by Occluding the Acidic Pocket by Lilia Leisle (11356934)

“…We confirmed experimentally that the interaction is predominantly driven by electrostatic forces, and using noncanonical amino acids as photo-cross-linkers, we identified 16 residues in ASIC1a contributing to Big Dyn binding. Covalently tethering Big Dyn to its ASIC1a binding site dramatically decreased the proton sensitivity of channel activation, suggesting that Big Dyn stabilizes a resting conformation of ASIC1a and dissociates from its binding site during channel opening.…”

GluN2A(D731N) decreases current amplitudes and shortens synaptic-like response time course. by Kai Gao (120150)

Subjects:

siRNA knockdown of PP6R1 or PP6c decreases repair of DNA double-strand breaks and sensitizes glioblastoma cells to radiation. by Jun Mi (374600)

Mutation of vOPG147 F55, T116 and T117 does not affect replication and production of VACV. by Xue-Mei Yi (18851202)

Subjects:

Pharmacologic blockade of 5LO modulates tau metabolism, ameliorates synaptic integrity and decreases neuroinflammation in the 3×Tg mice. by Jin Chu (358006)

Fibγ^Δ5 mice display decreased survival following <i>S. aureus</i> peritonitis. by Oscar Negrón (11965511)

Decreased activity of FASII favors the cold growth of the <i>ΔcshA</i> strain. by Vanessa Khemici (814639)

“…<p><b>(A)</b><i>fapR</i> mRNA levels decrease in ACC and biotin related suppressor strains. …”

JNK inhibitor AS601245 decreased levels of Bim and CC3 proteins and reduced neuronal apoptosis and brain infarct volume in P7 rat after HI. by Deyuan Li (769599)

“…The infarct volume in the AS601245-treated brain was decreased by 58% compared with the DMSO controls (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0132998#pone.0132998.g004" target="_blank">Fig 4I</a>).…”

Keap1-Knockdown Decreases Fasting-Induced Fatty Liver via Altered Lipid Metabolism and Decreased Fatty Acid Mobilization from Adipose Tissue by Jialin Xu (40952)

“…</p> <p>Conclusion</p><p>Enhanced Nrf2 activity via Keap1-KD decreased fasting-induced steatosis, pointing to an important function of Nrf2 on lipid metabolism under the condition of nutrient deprivation.…”

Altered energy expenditure and decreased respiratory exchange ratio in Y1Y5^−/− mice on chow. by Amy D. Nguyen (153830)

Assays of TUNEL revealed a decreased number of apoptotic cell after oroxylin A treatment. by Shu-Fang Lin (4167091)

Decreased production of antiviral factors in patients infected with SARS-CoV-2 due to reduced TLR7 expression by Julia Cataldo Lima (22811497)

“…<p>The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic presents a major global health challenge. …”

Toca-1 recruitment around wild-type bacteria is associated with decreased recruitment of LC3 and autophagy markers. by Leigh A. Baxt (550378)

The <i>virB</i> promoter activity is decreased in the <i>lovhk</i>::<i>km</i> mutant in <i>B</i>. <i>abortus</i>. by Gabriela Sycz (741267)

(A) Maximum percent decrease in FEV for each patient from postdose/pre-challenge after treatment with placebo (DB-placebo) or levalbuterol (DB-levalbuterol) during the double-blind period for each patient by D.S. Pearlman (92703)

VEGFR2/VEGF-A ligand binding decreased ranibizumab and aflibercept mediated CCL2, CCL5, and CX3CL1 mRNA and protein levels in HCAECs. by Clare Arnott (2557705)

IL-8 secretion decreased from TLR5 silenced (siRNA) Caco-2BBe cells exposed to flagellin. by Tonyia Eaves-Pyles (344135)

“…<p><b>A. </b><i>S. dublin</i> flagellin was added to the AP or BL surface of polarized Caco-2BBe cells where TLR5 was knocked down using siRNA. …”

The effect of instilling the ophthalmic solution on the LF/HF ratio and typical cases of fluctuations in the LF/HF ratio over time in the DE and non-DE groups. by Minako Kaido (309626)

Subjects:

DPOAE responses are decreased one week after treatment with 8,000 mg/kg HPβCD. by Mark A. Crumling (107429)