Model of adaptations associated with the development of high-level β-lactam resistance. by Viralkumar V. Panchal (9167076)

“…<p>Strain <i>lysA</i>::p<i>mecA</i> (SJF4996) (left) expresses chromosomal <i>mecA</i>, with PBP2A protein (red hour glass) incorporated into the cell envelope. …”

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…The corresponding epigenetic functional cellular responses are observed: histone-3 acetylation, DNA hypomethylation, and decreased histone-3 methylation at lysine-9. These chemical probes, multitarget epigenetic inhibitors, were validated against the multiple myeloma cell line MM1.S, demonstrating promising <i>in vitro</i> activity of <b>12a</b> (CM-444) with GI₅₀ of 32 nM, an adequate therapeutic window (>1 log unit), and a suitable pharmacokinetic profile. …”

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…The corresponding epigenetic functional cellular responses are observed: histone-3 acetylation, DNA hypomethylation, and decreased histone-3 methylation at lysine-9. These chemical probes, multitarget epigenetic inhibitors, were validated against the multiple myeloma cell line MM1.S, demonstrating promising <i>in vitro</i> activity of <b>12a</b> (CM-444) with GI₅₀ of 32 nM, an adequate therapeutic window (>1 log unit), and a suitable pharmacokinetic profile. …”

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…The corresponding epigenetic functional cellular responses are observed: histone-3 acetylation, DNA hypomethylation, and decreased histone-3 methylation at lysine-9. These chemical probes, multitarget epigenetic inhibitors, were validated against the multiple myeloma cell line MM1.S, demonstrating promising <i>in vitro</i> activity of <b>12a</b> (CM-444) with GI₅₀ of 32 nM, an adequate therapeutic window (>1 log unit), and a suitable pharmacokinetic profile. …”

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…The corresponding epigenetic functional cellular responses are observed: histone-3 acetylation, DNA hypomethylation, and decreased histone-3 methylation at lysine-9. These chemical probes, multitarget epigenetic inhibitors, were validated against the multiple myeloma cell line MM1.S, demonstrating promising <i>in vitro</i> activity of <b>12a</b> (CM-444) with GI₅₀ of 32 nM, an adequate therapeutic window (>1 log unit), and a suitable pharmacokinetic profile. …”

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…The corresponding epigenetic functional cellular responses are observed: histone-3 acetylation, DNA hypomethylation, and decreased histone-3 methylation at lysine-9. These chemical probes, multitarget epigenetic inhibitors, were validated against the multiple myeloma cell line MM1.S, demonstrating promising <i>in vitro</i> activity of <b>12a</b> (CM-444) with GI₅₀ of 32 nM, an adequate therapeutic window (>1 log unit), and a suitable pharmacokinetic profile. …”

Krüppel-Like Transcription Factor KLF1 Is Required for Optimal γ- and β-Globin Expression in Human Fetal Erythroblasts by Divya S. Vinjamur (2141155)

“…KLF1 also regulates BCL11A, a known repressor of adult γ-globin expression. …”

Identification of Sex and Female’s Reproductive Stage in Commercial Fish Species through the Quantification of Ribosomal Transcripts in Gonads by Iratxe Rojo-Bartolomé (2502772)

“…<div><p>The estimation of maturity and sex of fish stocks in European waters is a requirement of the EU Data Collection Framework as part of the policy to improve fisheries management. …”

miR-223 Is a Coordinator of Breast Cancer Progression as Revealed by Bioinformatics Predictions by Eva Maria Pinatel (506111)

“…Among these genes, we showed that protein levels for STAT5A, ITGA3 and NRAS were modulated by miR-223. In addition, we proved that STAT5A is a direct miR-223 target and highlighted a possible correlation between miR-223 and STAT5A in migration and chemotherapy response. …”

Polycyclic Aromatic Hydrocarbons Reciprocally Regulate IL-22 and IL-17 Cytokines in Peripheral Blood Mononuclear Cells from Both Healthy and Asthmatic Subjects by Coline Plé (720516)

“…Diesel exhaust particle (DEP)-PAH and Benzo[a]Pyrene (B[a]P) stimulation further increased IL-22 but decreased IL-17A production in both groups. …”

Circadian properties of the mathematical model reproduce the RAS-mediated effect on the clock. by Rukeia El-Athman (4669210)

“…<p>(A) Simplified network representation of the mathematical model. …”

Gα-cAMP/PKA pathway positively regulates pigmentation, chaetoglobosin A biosynthesis and sexual development in <i>Chaetomium globosum</i> by Yang Hu (315392)

“…<i>g</i>. albino mycelium, significant restriction on perithecium development and decreased production of ChA. RNA-seq profiling and qRT-PCR verified significantly fall in expression of corresponding genes, <i>e</i>.…”

Transcriptional changes detected in fecal RNA of neonatal dairy calves undergoing a mild diarrhea are associated with inflammatory biomarkers by Fernanda Rosa (4801314)

“…The concentration of serum amyloid A decreased over time. The mRNA expression of the proinflammatory related genes <i>TLR4</i>, <i>TNFA</i>, <i>IL8</i>, and <i>IL1B</i> had a positive quadratic effect of time. …”

The flow cytometry analysis for Caco-2 cells which had been cultured for 24 hours (A–F), 48 hours (G–L), or 72 hours (M–R) in CM. by Kitjasit Promsut (18823872)

Hypomethylation control by MucR is conserved in α-proteobacteria. by Silvia Ardissone (3594635)

“…Expression of <i>mucR</i>^<i>Sm</i> from P_<i>van</i> on pMT335 decreases beta-galactosidase activity of P<i>a1635</i> and P<i>a2245</i>. …”

Cyano-Bridged Re₆Q₈ (Q = S, Se) Cluster-Cobalt(II) Framework Materials:  Versatile Solid Chemical Sensors by Laurance G. Beauvais (2505370)

“…Spectroscopic and magnetic data confirm the change in coordination geometry, and the trends in solvent responses (e.g., methanol < ethanol < <i>n</i>-propanol < <i>i</i>-propanol) are consistent with a decreased ability to support the bridging water ligands of the clusters as steric bulk increases. …”

Increased repression of mitotic exit genes by <i>yhp1-13A yox1-9A</i> improves the fitness of condensin mutants. by Michelle M. Conti (13514386)

Results of RNA-seq experiments following acute overexpression of Yhp1, Yhp1-13A, Yox1 and Yox1-9A. by Michelle M. Conti (13514386)

Upper panel: The minimum-norm solution for the difference between the Grand Means of the tinnitus and the control groups indicates a greater prefrontal activity (dark shading) in t... by Nathan Weisz (3118)

“…Lower Panel: Correlating relative frontal activity (as compared to temporal sources) of each individual with the source location of the regional source results in a quadratic trend that is more pronounced for the right hemisphere.…”

PM_2.5 variations by daily hour interval. by Daniele Pala (1524016)