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non decrease » point decrease (Expand Search), note decreased (Expand Search), fold decrease (Expand Search)
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225961
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225962
DataSheet1_α-Mangostin Alleviated Inflammation in Rats With Adjuvant-Induced Arthritis by Disrupting Adipocytes-Mediated Metabolism-Immune Feedback.PDF
Published 2025“…<p>A previously identified anti-rheumatic compound α-mangostin (MAN) possesses notable metabolism regulatory properties. …”
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225963
Data_Sheet_1_Intraocular complement activation is related to retinal vascular and neuronal degeneration in myopic retinopathy.docx
Published 2023“…The levels of complement proteins including C1q, C3, C3b/iC3b, C4, CFB, CFH, C2, C4b, C5, C5a, CFD, MBL and CFI in the aqueous humour were measured using the Luminex Multiplexing system. …”
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225964
Downregulation of cancer-associated fibroblast exosome-derived miR-29b-1-5p restrains vasculogenic mimicry and apoptosis while accelerating migration and invasion of gastric cancer...
Published 2023“…<p><b>Background:</b> Cancer-associated fibroblast (CAF) exosomal miRNAs have gradually a hot spot in cancer therapy. This study mainly explores the effect of CAF-derived exosomal miR-29b-1-5p on gastric cancer (GC) cells.…”
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225965
Table_1_Sex-Differences and Associations Between Complement Activation and Synovial Vascularization in Patients with Late-Stage Knee Osteoarthritis.docx
Published 2022“…Additionally, males with high C5 had a higher synovial fluid concentration of sC5b-C9 compared to males with low C5. …”
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225966
Proposed model for extracellular/intracellular Gal-9 <i>trans</i> and <i>cis</i> association with Tim-3 in regulation of monocyte inflammatory cytokine expressions through TLR sign...
Published 2013“…Intracellular Gal-9 also inhibits STAT3 but not STAT-1 phosphorylation, leading to increased IL-12 and decreased IL-23 gene transcriptions. However, intracellular Gal-9 appears to reduce Tim-3 cell surface expression by two distinct mechanisms: <i>cis</i> association/internalization and transcriptional inhibition, through a STAT-3-independent but possibly T-bet-dependent pathway (10). …”
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225967
Twsg1 null mice were resistant to podocyte injury.
Published 2014“…<p>(<b>A</b>) Twsg1<sup>+/+</sup>:NEP25 and Twsg1<sup>LacZ/LacZ</sup>:NEP25 mice were injected with immunotoxin and analyzed seven days later. …”
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225968
Initial assessment of βHB treatment effects.
Published 2024“…<p>A) In experiment 1, body weight was reduced on day 1 after ICH (day 1, p<0.0001), and the βHB group weighed more than the VEH group on day 1 (p = 0.0250). …”
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225969
Image_2_Phenotypic changes of γδ T cells in Plasmodium falciparum placental malaria and pregnancy outcomes in women at delivery in Cameroon.jpeg
Published 2024“…This study sought to investigate the involvement of γδ T cells and its subsets in placental Plasmodium falciparum malaria.</p>Methods<p>In a case-control study conducted in Yaoundé, Cameroon from March 2022 to May 2023, peripheral, placental and cord blood samples were collected from 50 women at delivery (29 PM negative: PM- and 21 PM positive: PM+; as diagnosed by light microscopy). …”
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225970
Image_4_Organelle Crosstalk Regulators Are Regulated in Diseases, Tumors, and Regulatory T Cells: Novel Classification of Organelle Crosstalk Regulators.tif
Published 2021“…<p>To examine whether the expressions of 260 organelle crosstalk regulators (OCRGs) in 16 functional groups are modulated in 23 diseases and 28 tumors, we performed extensive -omics data mining analyses and made a set of significant findings: (1) the ratios of upregulated vs. downregulated OCRGs are 1:2.8 in acute inflammations, 1:1 in metabolic diseases, 1:1.2 in autoimmune diseases, and 1:3.8 in organ failures; (2) sepsis and trauma-upregulated OCRG groups such as vesicle, mitochondrial (MT) fission, and mitophagy but not others, are termed as the cell crisis-handling OCRGs. …”
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225971
Image_9_Phenotypic changes of γδ T cells in Plasmodium falciparum placental malaria and pregnancy outcomes in women at delivery in Cameroon.jpeg
Published 2024“…This study sought to investigate the involvement of γδ T cells and its subsets in placental Plasmodium falciparum malaria.</p>Methods<p>In a case-control study conducted in Yaoundé, Cameroon from March 2022 to May 2023, peripheral, placental and cord blood samples were collected from 50 women at delivery (29 PM negative: PM- and 21 PM positive: PM+; as diagnosed by light microscopy). …”
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225972
Image_2_Organelle Crosstalk Regulators Are Regulated in Diseases, Tumors, and Regulatory T Cells: Novel Classification of Organelle Crosstalk Regulators.tif
Published 2021“…<p>To examine whether the expressions of 260 organelle crosstalk regulators (OCRGs) in 16 functional groups are modulated in 23 diseases and 28 tumors, we performed extensive -omics data mining analyses and made a set of significant findings: (1) the ratios of upregulated vs. downregulated OCRGs are 1:2.8 in acute inflammations, 1:1 in metabolic diseases, 1:1.2 in autoimmune diseases, and 1:3.8 in organ failures; (2) sepsis and trauma-upregulated OCRG groups such as vesicle, mitochondrial (MT) fission, and mitophagy but not others, are termed as the cell crisis-handling OCRGs. …”
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225973
DataSheet_1_TLR2/TLR4-Enhanced TIPE2 Expression Is Involved in Post-Hemorrhagic Shock Mesenteric Lymph-Induced Activation of CD4+T Cells.doc
Published 2022“…</p>Conclusion<p>TIPE2 improves the PHSML-mediated CD4<sup>+</sup>T cells dysfunction by regulating TLR2/TLR4 pathway, providing a new intervention target following hemorrhagic shock-induced immune dysfunction.…”
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225974
Table4_The correlation between Diabetes and age-related degeneration and the static and dynamic 3D mechanical distribution of different plantar regions.docx
Published 2024“…</p>Materials and methods<p>A total of 20 HY adults, 16 HO adults and 15 diabetic patients were included. …”
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225975
Data_Sheet_1_City-level meteorological conditions modify the relationships between exposure to multiple air pollutants and the risk of pediatric hand, foot, and mouth disease in th...
Published 2023“…</p>Methods<p>For each of the 17 cities in the Sichuan Basin, we obtained estimates of the relationship between exposures to multiple air pollutants and childhood HFMD risk by using a unified distributed lag nonlinear model (DLNM). …”
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225976
Data_Sheet_1_Anti-hyperuricemic and Anti-inflammatory Effects of Marantodes pumilum as Potential Treatment for Gout.docx
Published 2020“…The anti-hyperuricemic activity was initially assessed by XO inhibition with a spectrophotometric in vitro assay. The most active extract was further investigated on hyperuricemic rat model induced by potassium oxonate to determine serum uric acid levels and liver XO effect. …”
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225977
<i>Hirsutella sinensis</i> Attenuates Aristolochic Acid-Induced Renal Tubular Epithelial-Mesenchymal Transition by Inhibiting TGF-β1 and Snail Expression
Published 2016“…These results suggest Snail might be a potential target of HS effect.</p><p>Conclusion</p><p>HS is able to antagonize, to some extent, tubular EMT and renal interstitial fibrosis caused by AA, which might be related to its inhibitory effects on the TGF-β1 and Snail expression.…”
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225978
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225979
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225980
DataSheet_1_Suppression of microRNA-222-3p ameliorates ulcerative colitis and colitis-associated colorectal cancer to protect against oxidative stress via targeting BRG1 to activat...
Published 2023“…Recent studies have indicated that microRNA-222-3p (miR-222-3p) is increased in colon of UC and colorectal cancer (CRC) patients, and miR-222-3p is a crucial regulator of oxidative stress. However, whether miR-222-3p influences IEC oxidative stress in UC and CAC remains unknown. …”