Image_2_Safety and Immunological Evaluation of Interleukin-21 Plus Anti-α4β7 mAb Combination Therapy in Rhesus Macaques.jpg by Maria Pino (109981)

“…<p>Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infections compromise gut immunological barriers, inducing high levels of inflammation and a severe depletion of intestinal CD4⁺ T cells. …”

Pathogenic <i>NLGN1</i> variants exhibit abnormal sub-localization and expression. by Moe Nakanishi (4392145)

“…<p>(A) Fluorescence images of COS7 cells transfected WT or mutant NLGN1 with HA-tag. …”

Table_1_Peppermint extract improves egg production and quality, increases antioxidant capacity, and alters cecal microbiota in late-phase laying hens.docx by Miaomiao Bai (9549833)

“…A total of 0.4% PE supplementation increased the cecal richness of gram-positive bacteria and decreased the richness of gram-negative and potentially pathogenic bacteria compared with the 0.1% PE group (P < 0.05). …”

<i>Leishmania donovani</i> induced Unfolded Protein Response delays host cell apoptosis in PERK dependent manner by Kumar Abhishek (848214)

“…<div><p>Background</p><p>Endoplasmic reticulum (ER) stress generated unfolded stress response (UPR) is a basic survival mechanism which protects cell under unfavourable conditions. …”

The animal experimental protocol. by Yuanqiang Lv (20623742)

“…</p><p>Results and conclusion</p><p>The results indicated that oxidative stress and immune response factor expressions quantity in Gallus gallus decreased significantly after 14 days of treatment, compared with model group, the low-dose treatment group’s SOD1, SOD3, GPX1, GPX2, GSR, H6DP, and HO-1 genes in liver were downregulated by 36.03%, 40.01%, 45.86%, 40.79%, 37.68%, 25.04%, and 29.89%, the IL-1, IL-2, IL-4, IL-6, IgA, IgM, and IgG genes in blood and spleen were downregulated by 26.59%, 34.19%, 21.19%, 28.18%, 35.93%, 12.67%, 21.81 and 35.93%, 22.85%, 21.19%, 28.78%, 35.93%, 15.36%, 29.73%. …”

Image_3_Tannic acid reduced apparent protein digestibility and induced oxidative stress and inflammatory response without altering growth performance and ruminal microbiota diversi... by Zuo Wang (8502849)

“…The increments of alanine aminotransferase (ALT), triglyceride (TG), cortisol (CORT), total antioxidant capacity (T-AOC), interleukin (IL)-1β, IL-6, and serumamyloid A (SAA), and decrements of globulin (GLB), immunoglobulin G (IgG), cholinesterase (CHE), glutathione reductase (GR), creatinine (CRE), growth hormone (GH), high-density lipoprotein cholesterol (HDLC), and insulin-like growth factor 1 (IGF-1) to different extents by TA addition were observed. …”

Data_Sheet_1_Association between environmental lead/cadmium co-exposure in drinking water and soil and type 2 diabetes mellitus/obesity in Southern China.docx by Zhi Qu (553547)

“…Besides, with ADDs of Pb exposure was increased by 1 μg/kg bw/d and WHR decreasing by 0.01–0.02, and WC decreasing by 2.22–4.67 cm. …”

Data Sheet 1_An integrative analysis of ASCL1 in breast cancer and inhibition of ASCL1 increases paclitaxel sensitivity by activating ferroptosis via the CREB1/GPX4 axis.docx by Xiaolu Yang (285041)

“…</p>Conclusions<p>ASCL1 exerts oncogenic effects in BC and represents a potential therapeutic target for intervention.…”

Image_1_Influences of Maternal Conjugated Linoleic Acid and Essential Fatty Acid Supply During Late Pregnancy and Early Lactation on T and B Cell Subsets in Mesenteric Lymph Nodes... by Wendy Liermann (9774182)

“…The current preliminary study investigated effects of a maternal fatty acid supplementation (MFAS) during late pregnancy and early lactation with coconut oil (CON, control), CLA (Lutalin®), or CLA + EFA (Lutalin® linseed oil; safflower oil) on plasma fatty acid composition and T and B cell subsets in mesenteric lymph nodes (MLN) and the small intestine of 5-day-old calves. …”

Glucose-Dependent Insulin Secretion in Pancreatic β-Cell Islets from Male Rats Requires Ca²⁺ Release via ROS-Stimulated Ryanodine Receptors by Paola Llanos (750250)

“…Addition of stimulatory glucose or H₂O₂ (in basal glucose) to β-cells disaggregated from islets increased RyR2 <i>S</i>-glutathionylation to similar levels, measured by a proximity ligation assay; in contrast, NAC significantly reduced the RyR2 <i>S</i>-glutathionylation increase produced by stimulatory glucose. …”

Table_4_Tannic acid reduced apparent protein digestibility and induced oxidative stress and inflammatory response without altering growth performance and ruminal microbiota diversi... by Zuo Wang (8502849)

“…The increments of alanine aminotransferase (ALT), triglyceride (TG), cortisol (CORT), total antioxidant capacity (T-AOC), interleukin (IL)-1β, IL-6, and serumamyloid A (SAA), and decrements of globulin (GLB), immunoglobulin G (IgG), cholinesterase (CHE), glutathione reductase (GR), creatinine (CRE), growth hormone (GH), high-density lipoprotein cholesterol (HDLC), and insulin-like growth factor 1 (IGF-1) to different extents by TA addition were observed. …”

Suppression of lncRNA GAS6-AS2 alleviates sepsis-related acute kidney injury through regulating the miR-136-5p/OXSR1 axis <i>in vitro</i> and <i>in vivo</i> by Hongrui Cui (12001906)

“…<p>Acute kidney injury (AKI) is a common complication of sepsis and increase morbidity and mortality. …”

Tetraspanin Family Member, CD82, Regulates Expression of EZH2 via Inactivation of p38 MAPK Signaling in Leukemia Cells by Chie Nishioka (1980676)

“…Real-time RT-PCR and western blot analysis were performed to examine the effect of CD82 knockdown on the expression of the polycomb group member, enhancer of zeste homolog 2 (EZH2), in leukemia cells. A chromatin immunoprecipitation assay was performed to examine the effect of CD82 expression on the amount of EZH2 bound to the promoter regions of tumor suppressor genes in leukemia cells. …”

Image_1_Grain Mineral Accumulation Changes in Chinese Maize Cultivars Released in Different Decades and the Responses to Nitrogen Fertilizer.jpeg by Song Guo (194234)

“…Here, field experiments were conducted at two locations in China over 2 years (2010 and 2011). Under a normal N application rate (240 kg N ha⁻¹), 24 maize cultivars that had been bred and released between 1930 and 2010 were evaluated for the elemental concentrations in the grains. …”

Table S1-S3; Figure S1-S13 from BET Bromodomain Inhibition Cooperates with PD-1 Blockade to Facilitate Antitumor Response in <i>Kras</i>-Mutant Non–Small Cell Lung Cancer by Dennis O. Adeegbe (11633683)

“…Tumor-infiltrating KLRG1+ CD4+Foxp3+ Tregs exhibit a highly activated profile but resemble natural peripheral Tregs. …”

Flowchart of the entire experimental process. by Jing Zhang (23775)

“…Dapagliflozin increased serum GSH-Px and SOD levels and decreased IL-1β, IL-6, TNF-α and MDA levels (P < 0.05) in a rabbit model of heart failure. …”

Integrin receptor-targeted, doxorubicin-loaded cerium oxide nanoparticles delivery to combat glioblastoma by Gayathri Koula (19338250)

“…</p> <p>The functionalization of nanoparticles with RGD peptide facilitated their translocation across the blood–brain barrier successfully.</p> <p>A three-fold increase in the survivability of mice with CeNP+Dox+RGD treatment was observed compared with control and other treated groups in the orthotopic mice glioma models.…”

Image_4_Tannic acid reduced apparent protein digestibility and induced oxidative stress and inflammatory response without altering growth performance and ruminal microbiota diversi... by Zuo Wang (8502849)

“…The increments of alanine aminotransferase (ALT), triglyceride (TG), cortisol (CORT), total antioxidant capacity (T-AOC), interleukin (IL)-1β, IL-6, and serumamyloid A (SAA), and decrements of globulin (GLB), immunoglobulin G (IgG), cholinesterase (CHE), glutathione reductase (GR), creatinine (CRE), growth hormone (GH), high-density lipoprotein cholesterol (HDLC), and insulin-like growth factor 1 (IGF-1) to different extents by TA addition were observed. …”

Data_Sheet_1_Altered intestinal microbiota composition with epilepsy and concomitant diarrhea and potential indicator biomarkers in infants.docx by Tingting Liu (267387)

“…The bacterial community network of the ED had a more compact local interconnection, which was in contrast to that of PT. …”

<b><i>Uterine Artery Bulk RNA sequencing and transcriptomics</i></b> from non-pregnant wild type, <i>Rgs</i>2 KO, <i>Rgs5 </i>KO, and <i>Rgs2/5 </i>double knockout mice by Bo Sun (18419375)

“…<p dir="ltr">G protein regulation by regulators of G protein signaling (RGS) proteins of the R4/B family plays a key role in vascular tone maintenance; However, the regulatory mechanisms are poorly understood. …”