Table 2_Dietary retinoic acid improved the growth, lipid metabolism and immune status in Macrobrachium rosenbergii.docx by Qin-Cheng Huang (20944886)

“…Additionally, 296 mg/kg dietary RA increased the protein expression of RXR, CAMKKβ and phospho-AMPK. A dietary RA level of 296 mg/kg could decrease oxidative stress by upregulating the expression of peroxiredoxin 5 (prx5) and improve immunity by upregulating expression of toll-like receptor 2 (toll2), myeloid differentiation factor 88 (myd88) and dosal in the hepatopancreas. …”

Image_1_Empagliflozin suppresses mitochondrial reactive oxygen species generation and mitigates the inducibility of atrial fibrillation in diabetic rats.TIF by Takuya Koizumi (2667574)

“…We aimed to further investigate this, and examine whether the SGLT2-i empagliflozin suppresses mitochondrial-ROS generation and mitigates fibrosis.</p>Methods<p>A high-fat diet and low-dose streptozotocin treatment were used to induce type-2 DM (T2DM) in Sprague-Dawley rats. …”

Presentation_1_Thyroid hormone elicits intergenerational epigenetic effects on adult social behavior and fetal brain expression of autism susceptibility genes.pdf by Maria Elena Martinez (3910087)

“…<p>Genetic mutations identified in genome-wide association studies can only explain a small percentage of the cases of complex, highly heritable human conditions, including neurological and neurodevelopmental disorders. …”

Table1_Revealing the Mechanism of Huazhi Rougan Granule in the Treatment of Nonalcoholic Fatty Liver Through Intestinal Flora Based on 16S rRNA, Metagenomic Sequencing and Network... by Yingying Liu (360782)

“…Analysis of intestinal flora showed that HRG changed the composition of intestinal flora, which was characterized by a decrease in the Firmicutes/Bacteroidetes ratio. …”

Data_Sheet_1_Deregulation of mTORC1-TFEB axis in human iPSC model of GBA1-associated Parkinson’s disease.docx by Fahad Mubariz (16010003)

“…Using PD patients’ induced-pluripotent stem cells (iPSCs), we examined TFEB activity and regulation of the ALP in dopaminergic neuronal cultures generated from iPSC lines harboring heterozygous GBA1 mutations and the CRISPR/Cas9-corrected isogenic controls. Our data showed a significant decrease in TFEB transcriptional activity and attenuated expression of many genes in the CLEAR network in GBA1 mutant neurons, but not in the isogenic gene-corrected cells. …”

Data_Sheet_1_Perovskite Photodetectors Based on p-i-n Junction With Epitaxial Electron-Blocking Layers.PDF by Yubing Xu (8877134)

“…This Au-MAPbI₃-MAPbBr₃-MAPbBr_2.5Cl_0.5PSCs-C60-PCBM-Ag heterostructure can be used as excellent X-ray photodetector (XPD) due to its low dark current density of 6.97 × 10⁻¹¹ A cm⁻² at −0.5 V bias, high responsivity of 870 mA/W at −100 V bias and X-ray sensitivity as high as 59.7 μC mGy⁻¹ cm⁻² at −50 V bias.…”

The changes in the expression of downstream molecules of each compound. by Yuya Fujii (7326947)

“…Axin2, downstream molecule of Wnt/β-catenin pathway; LTBP1, downstream molecule of TGF-β pathway; Id, downstream molecule of BMP pathway; DLL1, downstream molecule of the Notch pathway (n = 5). All data are presented as the mean ± SEM. *p < 0.05, as per Wilcoxon rank sum test.…”

ACE effectors in the heart and lung tissues. by Victoria E. Tikhomirova (829899)

“…<p>Conformational fingerprinting of heart and lung ACEs was performed with a set of 17 mAbs to ACE as in the legend to <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0181976#pone.0181976.g003" target="_blank">Fig 3</a>. …”

Pediatric enteral nutrition therapy for burn victims: when should it be initiated? by Mariéle Valentini (7502039)

“…There was a higher incidence of diarrhea and vomiting and decreased intestinal permeability in the early group. …”

Intrinsic properties of CNNs. by Cathrin B. Canto (3350390)

“…Therefore, values above 1 indicate post-inhibitory rebound, while values lower than 1 indicate a decreased firing rate after the inhibition. The color coding in B-F corresponds to the neurons presented in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0165887#pone.0165887.g001" target="_blank">Fig 1A</a> (different colours of purple; dots are also encircled), to the neurons presented in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0165887#pone.0165887.g002" target="_blank">Fig 2B</a> (red, black and blue neuron; crosses are encircled), and finally all morphologically identified neurons presented in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0165887#pone.0165887.g003" target="_blank">Fig 3</a> (the colours of the dots have the same colour as the reconstructions of the neurons). …”

Simulated dependence of [Ca²⁺] on electrical coupling following modulation of other K_ATP parameters. by Aleena M. Notary (625801)

“…<b>F).</b> Mean [Ca²⁺] duty cycle upon decreased <i>p</i>^<i>’</i>_<i>o</i> values at <i>k</i>^<i>’</i>_<i>1/2</i> = 6, as in E. …”

Defective optineurin causes autophagy failure. by Masaya Fukushi (216872)

“…(E) Autophagy flux after infection is shown as a decreased GFP/RFP ratio in parental (<i>n</i> = 4) and two <i>Optn</i>-KO clones (<i>n</i> = 4 each) of GFP-LC3-RFP-LC3ΔG MEFs infected with SeV (Cantell strain). …”

Characterization of Heterogeneity and Dynamics of Lysis of Single Bacillus subtilis Cells upon Prophage Induction During Spore Germination, Outgrowth, and Vegetative Growth Using R... by Mei-yan Wu (9921201)

“…Major findings of this work are as follows: (i) After addition of xylose to trigger prophage induction, the intensities of Raman spectral bands associated with nucleic acids of single cells in induced cultures gradually fell to zero, in contrast to the much smaller changes in protein band intensities and no changes in nucleic acid bands in uninduced cultures; (ii) the nucleic acid band intensities from an individual induced cell exhibited a rapid decrease, following a long lag period; (iii) after the addition of nutrient-rich medium with xylose, single spores underwent a long period (228 ± 41.4 min) for germination, outgrowth, and vegetative growth, followed by a short period of cell burst in 1.5 ± 0.8 min at a cell length of 8.2 ± 5.5 μm; (iv) the latent time (<i>T</i>_latent) between the addition of xylose and the start of cell burst was heterogeneous in cell populations; however, the period (Δ<i>T</i>_burst) from the latent time to the completion of cell lysis was quite small; (v) in a poor medium with l-alanine alone, addition of xylose caused prophage induction following spore germination but with longer <i>T</i>_latent and Δ<i>T</i>_burst times and without cell elongation; (vi) spontaneous prophage induction and lysis of individual cells from spores in a minimal nutrient medium were observed without xylose addition, and cell length prior to cell lysis was ∼4.1 μm, but spontaneous prophage induction was not observed in a rich medium; (vii) in a rich medium, addition of xylose at a time well after spore germination and outgrowth significantly shortened the average <i>T</i>_latent time. …”

Characterization of Heterogeneity and Dynamics of Lysis of Single Bacillus subtilis Cells upon Prophage Induction During Spore Germination, Outgrowth, and Vegetative Growth Using R... by Mei-yan Wu (9921201)

“…Major findings of this work are as follows: (i) After addition of xylose to trigger prophage induction, the intensities of Raman spectral bands associated with nucleic acids of single cells in induced cultures gradually fell to zero, in contrast to the much smaller changes in protein band intensities and no changes in nucleic acid bands in uninduced cultures; (ii) the nucleic acid band intensities from an individual induced cell exhibited a rapid decrease, following a long lag period; (iii) after the addition of nutrient-rich medium with xylose, single spores underwent a long period (228 ± 41.4 min) for germination, outgrowth, and vegetative growth, followed by a short period of cell burst in 1.5 ± 0.8 min at a cell length of 8.2 ± 5.5 μm; (iv) the latent time (<i>T</i>_latent) between the addition of xylose and the start of cell burst was heterogeneous in cell populations; however, the period (Δ<i>T</i>_burst) from the latent time to the completion of cell lysis was quite small; (v) in a poor medium with l-alanine alone, addition of xylose caused prophage induction following spore germination but with longer <i>T</i>_latent and Δ<i>T</i>_burst times and without cell elongation; (vi) spontaneous prophage induction and lysis of individual cells from spores in a minimal nutrient medium were observed without xylose addition, and cell length prior to cell lysis was ∼4.1 μm, but spontaneous prophage induction was not observed in a rich medium; (vii) in a rich medium, addition of xylose at a time well after spore germination and outgrowth significantly shortened the average <i>T</i>_latent time. …”

Characterization of Heterogeneity and Dynamics of Lysis of Single Bacillus subtilis Cells upon Prophage Induction During Spore Germination, Outgrowth, and Vegetative Growth Using R... by Mei-yan Wu (9921201)

“…Major findings of this work are as follows: (i) After addition of xylose to trigger prophage induction, the intensities of Raman spectral bands associated with nucleic acids of single cells in induced cultures gradually fell to zero, in contrast to the much smaller changes in protein band intensities and no changes in nucleic acid bands in uninduced cultures; (ii) the nucleic acid band intensities from an individual induced cell exhibited a rapid decrease, following a long lag period; (iii) after the addition of nutrient-rich medium with xylose, single spores underwent a long period (228 ± 41.4 min) for germination, outgrowth, and vegetative growth, followed by a short period of cell burst in 1.5 ± 0.8 min at a cell length of 8.2 ± 5.5 μm; (iv) the latent time (<i>T</i>_latent) between the addition of xylose and the start of cell burst was heterogeneous in cell populations; however, the period (Δ<i>T</i>_burst) from the latent time to the completion of cell lysis was quite small; (v) in a poor medium with l-alanine alone, addition of xylose caused prophage induction following spore germination but with longer <i>T</i>_latent and Δ<i>T</i>_burst times and without cell elongation; (vi) spontaneous prophage induction and lysis of individual cells from spores in a minimal nutrient medium were observed without xylose addition, and cell length prior to cell lysis was ∼4.1 μm, but spontaneous prophage induction was not observed in a rich medium; (vii) in a rich medium, addition of xylose at a time well after spore germination and outgrowth significantly shortened the average <i>T</i>_latent time. …”

Integrity of AWC cilia structure is critical for proper localization of EGL-4. by Damien M. O'Halloran (185919)

“…Calcium levels in AWC have been shown to decrease after ligand binding <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000761#pgen.1000761-Chalasani1" target="_blank">[13]</a>. …”

Reversal of ROS induced autophagic vacuole formation in F-HABP07 upon polymeric HA supplementation. by Paramita Saha (473954)

“…<p>[<b>A to D</b>] <b><i>Polymeric </i><i>HA </i><i>supplementation </i><i>restores </i><i>cellular </i><i>homeostasis </i><i>in </i><i>F-HABP07 </i><i>cells</i></b>-- As a result of significant reduction in ROS generation as evident from the decreased fluorescence intensity upon H₂DCFDA treatment (<b>A</b> and <b>B</b>); about 25% revival of growth was observed in F-HABP07 cells (<b>C</b>). …”

Proof of Concept, Randomized, Placebo-Controlled Study of the Effect of Simvastatin on the Course of Age-Related Macular Degeneration by Robyn H. Guymer (168403)

“…<i>Intent to treat</i> multivariable logistic regression analysis, adjusted for age, sex, smoking and baseline AMD severity, showed a significant 2-fold decrease in the risk of progression in the simvastatin group: OR 0.43 (0.18–0.99), p = 0.047. …”

Data_Sheet_1_Coordinated Reset Vibrotactile Stimulation Induces Sustained Cumulative Benefits in Parkinson’s Disease.pdf by Kristina J. Pfeifer (10095703)

“…EEG recordings observed from study 1 indicated a significant decrease in off-medication cortical sensorimotor high beta power (21—30 Hz) at rest after 3 months of daily noisy vCR therapy. …”

Image_1_Defective Autophagy in T Cells Impairs the Development of Diet-Induced Hepatic Steatosis and Atherosclerosis.TIF by Jacob Amersfoort (6075341)

“…Taken together, T cell-specific deficiency of Atg7 resulted in a decrease in hepatic steatosis and limited inflammatory potency in the (naïve) T cell compartment in peripheral lymphoid tissues, which was associated with a strong reduction in experimental atherosclerosis.…”