Image2_ATF4-dependent and independent mitokine secretion from OPA1 deficient skeletal muscle in mice is sexually dimorphic.tif by Jennifer Streeter (19729264)

“…</p>Methods<p>We generated mice with homozygous floxed Opa1 and Atf4 alleles and a tamoxifen-inducible Cre transgene controlled by the human skeletal actin promoter to enable simultaneous depletion of OPA1 and ATF4 in skeletal muscle (mAO DKO). …”

DataSheet1_Shuangyu Tiaozhi decoction alleviates non-alcoholic fatty liver disease by improving lipid deposition, insulin resistance, and inflammation in vitro and in vivo.ZIP by Guoliang Yin (11894894)

“…Our findings reveal that SYTZD could alleviate NAFLD through a multi-component, multi-target, and multi-pathway mechanism of action.…”

Synthesis of Bis-β-Diketonate Lanthanide Complexes with an Azobenzene Bridge and Studies of Their Reversible Photo/Thermal Isomerization Properties by Cai-Ye Fu (7360043)

“…The ligand, bis-β-diketone with an azobenzene bridge (4,4′-(4,4,4-trifluoro-1,3-butanedione)­azobenzene, <b>H</b>_<b>2</b><b>L</b>), was prepared for the synthesis of a series of dinuclear lanthanide complexes with the formula <b>[Ln</b>_<b>2</b><b>L</b>_<b>3</b><b>(DMSO)</b>_<b>4</b><b>]</b> (Ln = Eu³⁺, Gd³⁺, Tb³⁺, and DMSO = dimethyl sulfoxide). …”

DataSheet_4_Jianpi Huayu Decoction Attenuates the Immunosuppressive Status of H22 Hepatocellular Carcinoma-Bearing Mice: By Targeting Myeloid-Derived Suppressor Cells.pdf by Yingjie Xie (8459550)

“…Therefore, that the proportion of CD11b⁺Gr-1⁺ cells increased in the spleen of tumor-bearing hosts may not be villainy after treatment, when these drugs suppress the immunosuppressive ability of CD11b⁺Gr-1⁺ cells and promote it mature to replenish dendritic cell, at the same time. Generally, JHD may be a complementary and alternative drug for attenuating the immunosuppressive status induced by hepatocellular carcinoma, possibly by promoting differentiation and inhibiting the immunosuppressive activity of MDSCs.…”

DataSheet3_Epigenetic Modifier Supplementation Improves Mitochondrial Respiration and Growth Rates and Alters DNA Methylation of Bovine Embryonic Fibroblast Cells Cultured in Diver... by Matthew S. Crouse (11446869)

“…Therefore, the experimental design was a 2 (levels of glucose) × 4 (levels of EM) factorial arrangement of treatments. …”

Table 4_Combined inhibition of dopamine D1/D2 receptors induces cognitive and emotional dysfunction through oxidative stress and dopaminergic neuron damage.xls by Xue Li (285380)

“…Immunofluorescence and WB confirmed a reduction in the dopaminergic neuron count after co-DR1/2I.…”

Data_Sheet_1_Birth outcomes, puberty onset, and obesity as long-term predictors of biological aging in young adulthood.PDF by Martin Jáni (3968681)

“…</p>Methods<p>We have conducted a second follow-up of the Czech part of the European Longitudinal Study of Pregnancy and Childhood (ELSPAC-CZ) prenatal birth cohort in young adulthood (52% male; age 28–30; n = 262) to determine the role of birth outcomes, pubertal timing, BMI, and body fat on biological aging. …”

Image4_The Prognostic Significance of RIMKLB and Related Immune Infiltrates in Colorectal Cancers.TIF by Yinghao Cao (456724)

“…In conclusion, RIMKLB expression is associated with survival outcomes and TIICs levels in patients with CRC, and therefore, might be a potential novel prognostic biomarker that reflects the immune infiltration status.…”

Table 2_Combined inhibition of dopamine D1/D2 receptors induces cognitive and emotional dysfunction through oxidative stress and dopaminergic neuron damage.xls by Xue Li (285380)

“…Immunofluorescence and WB confirmed a reduction in the dopaminergic neuron count after co-DR1/2I.…”

Data_Sheet_1_The temporal trend of disease burden attributable to metabolic risk factors in China, 1990–2019: An analysis of the Global Burden of Disease study.DOCX by Yingzhao Jin (14325774)

“…The AAPC value in rate of DALYs and death were higher in male patients than in female patients across 20 age groups. A double-peak pattern was observed for AAPC in the rate of DALYs and death, peaking at age 20–49 and at age 70–95 plus. …”

DataSheet_1_SRSF1 acts as an IFN-I-regulated cellular dependency factor decisively affecting HIV-1 post-integration steps.pdf by Helene Sertznig (9649127)

“…Type I interferons (IFN-I) play a crucial role in the innate immunity against HIV-1 by inducing the expression of IFN-stimulated genes (ISGs) including potent host restriction factors. …”

Sleep phenotypes of flies with higher expression of <i>dbt</i>^K/R mutant only during adulthood. by Jialin Wang (490082)

“…<p>(A) Sleep profile of flies with adult specific expression of <i>dbt</i>^K/R. …”

Concentrations of C, N, and P in time change. by Shizhen Xu (4474321)

“…It analyzed variation patterns of soil carbon, nitrogen, and phosphorus across different land-use types in the study area and explored the impacts of land-use types and seasonal climate fluctuations on these soil elements, aiming to provide a scientific basis for soil management. Results showed that during 2018–2019, the average organic carbon content in forestland soil (48.82 g/kg) was higher than that in grassland (38.32 g/kg) and cropland (30.80 g/kg). …”

S1 Dataset - by Emmanuel Kobina Mesi Edzie (14804111)

“…</p><p>Conclusion</p><p>The incidence rate of uterine fibroids increased as the years progressed and it is mostly high in 35–39 years age category, with a decreasing annual mean age trend indicative of early diagnosis.…”

Supplementary Material for: Incidence of Hyper Progressive Disease in Combination Immunotherapy and Anti-Programmed Cell Death Protein 1/Programmed Death-Ligand 1 Monotherapy for U... by Aoki T. (5246708)

“…<b><i>Methods:</i></b> This was a prospective and retrospective cohort study which enrolled 198 patients with unresectable HCC from January 2015 to December 2021 at the Kindai University Hospital. …”

DataSheet_3_Jianpi Huayu Decoction Attenuates the Immunosuppressive Status of H22 Hepatocellular Carcinoma-Bearing Mice: By Targeting Myeloid-Derived Suppressor Cells.pdf by Yingjie Xie (8459550)

“…Therefore, that the proportion of CD11b⁺Gr-1⁺ cells increased in the spleen of tumor-bearing hosts may not be villainy after treatment, when these drugs suppress the immunosuppressive ability of CD11b⁺Gr-1⁺ cells and promote it mature to replenish dendritic cell, at the same time. Generally, JHD may be a complementary and alternative drug for attenuating the immunosuppressive status induced by hepatocellular carcinoma, possibly by promoting differentiation and inhibiting the immunosuppressive activity of MDSCs.…”

DataSheet_2_Jianpi Huayu Decoction Attenuates the Immunosuppressive Status of H22 Hepatocellular Carcinoma-Bearing Mice: By Targeting Myeloid-Derived Suppressor Cells.pdf by Yingjie Xie (8459550)

“…Therefore, that the proportion of CD11b⁺Gr-1⁺ cells increased in the spleen of tumor-bearing hosts may not be villainy after treatment, when these drugs suppress the immunosuppressive ability of CD11b⁺Gr-1⁺ cells and promote it mature to replenish dendritic cell, at the same time. Generally, JHD may be a complementary and alternative drug for attenuating the immunosuppressive status induced by hepatocellular carcinoma, possibly by promoting differentiation and inhibiting the immunosuppressive activity of MDSCs.…”

Data Sheet 4_Cardioprotective effect of Yiqi Huoxue decoction on post-myocardial infarction injury mediated by Ca2+ flux through MAMs.pdf by Yufei Li (433737)

“…Yiqi Huoxue decoction (YQHX), a Traditional Chinese Medicine formula, shows potential for myocardial infarction (MI) prevention and treatment. …”

Presentation 1_Investigating the mechanisms of Sini San in alleviating inflammatory responses via multi-omics and the BDNF/TrkB/PI3K/AKT signaling pathway in depressive model rats.... by Jia-Wei Zeng (17670369)

“…Studies have shown that the inflammatory response is not merely a concomitant feature of depression but actively contributes to its pathogenesis via neuroimmune mechanisms. …”

DataSheet1_Isoquercitrin alleviates pirarubicin-induced cardiotoxicity in vivo and in vitro by inhibiting apoptosis through Phlpp1/AKT/Bcl-2 signaling pathway.CSV by Lei Wang (6656)

“…Isoquercitrin (IQC) is a natural flavonoid with anti-oxidant and anti-apoptosis properties. …”