Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3‑Oxo-3,4-dihydro‑2<i>H</i>‑ben... by Shuhei Ikeda (2380180)

Subjects:

Total Mechanical Unloading Minimizes Metabolic Demand of Left Ventricle and Dramatically Reduces Infarct Size in Myocardial Infarction by Keita Saku (714525)

“…The purpose of this study was to evaluate the differential impact of the support level of LVAD on MVO₂ and infarct size in a canine model of ischemia-reperfusion.</p><p>Methods</p><p>In 5 normal mongrel dogs, we examined the impact of LVAD on MVO₂ at 3 support levels: Control (no LVAD support), p-LVAD and t-LVAD. …”

RDA analysis of environmental factors and fungal community composition (A), diversity (B). by Xiaoqing Li (186909)

50 year old female with Libman-Sacks endocarditis complicated with an acute transient ischemic attack, past stroke, and seizure disorder. by Carlos A. Roldan (10151007)

SIRT5 deficiency suppresses mitochondrial ATP production and promotes AMPK activation in response to energy stress by Mengli Zhang (6331172)

“…In light of the SIRT5's roles in regulating mitochondrion function, we show here that SIRT5 deficiency leads to suppression of mitochondrial NADH oxidation and inhibition of ATP synthase activity. …”

Zileuton, 5-Lipoxygenase Inhibitor, Acts as a Chemopreventive Agent in Intestinal Polyposis, by Modulating Polyp and Systemic Inflammation by Elias Gounaris (52393)

“…Here we report that Zileuton, a specific 5-LO inhibitor, can prevent polyp formation by efficiently reducing the tumor-associated and systemic inflammation in APC^Δ468 mice.…”

Raw data 1–5. by Fateme Khorramroo (18086501)

Supplementary Material for: Allopregnanolone and Pregnanolone Are Reduced in the Hippocampus of Epileptic Rats, but Only Allopregnanolone Correlates with Seizure Frequency by Lucchi C. (9255995)

“…<b><i>Results:</i></b> Decreased allopregnanolone (–50%; <i>p</i> < 0.05, Mann-Whitney test) and pregnanolone levels (–64%; <i>p</i> < 0.01) were found in the hippocampus, whereas pregnenolone sulfate, pregnenolone, progesterone, and 5α-dihydroprogesterone were nonsignificantly reduced. …”

LPS administration demonstrated a significant decrease in the protein expression of both claudin-1 and occludin in BF fed mice as compared to control mice. by Valentina Di Caro (510473)

Plausibility of the zebrafish embryos/larvae as an alternative animal model for autism: A comparison study of transcriptome changes by Sangwoo Lee (1727713)

“…Specifically, we exposed zebrafish to valproic acid (0, 12.5, 25, 50, or 100 μM), which is a chemical known to induce autism-like effects. …”

Leptin deficit hypoxia exposed-MSCs failed to limit cardiac fibroblast activation, through TGF-β/Smad2 and MRTF-A. by Panpan Chen (307628)

A-C. Inhibitors of cell death (zVAD-fmk and Nec-1) do not rescue the BMP2-induced decrease in cell numbers. by Charlotte Lagler (4017212)

Effect of MF (2 MT, 50 Hz) on VEGFR expression and activation. by Simona Delle Monache (402973)

“…<p>Protein of equal quantity was separated by 8% SDS-page and electroblotted on to a PVDF membrane. Representative blots show effects exerted by MF (2 mT, 50 Hz) on VEGFR2 total expression and phosphorylation after 1 h, 6 h and 12 h of exposure A). …”

ChemRich enrichment of the top 50 most changed metabolites for SCD. by Juliette Cooke (11402543)

A small group of plains zebra taken at a real-world equivalent of 16.4 m as they may appear to a human (a,c,e) and lion (b,d,f) under photopic (bright; daylight), mesopic (dim; dus... by Amanda D. Melin (270203)

50% reduction of kinesin-1 or dynein is sufficient to perturb neuronal growth. by Gary J. Iacobucci (192833)

“…<p>(<b>A</b>) Representative neuronal cultures expressing APP-YFP and APP-YFP with 50% genetic reduction of either kinesin-1 or dynein are shown at day 1 and day 2. …”

Dependence of seizure transition times on (<i>dν</i>_<i>se</i>/<i>dt</i>)^−1/2 with the default parameters as in Table 1 and Δ ranges from 2 s to 50 s. by F. Deeba (8661837)

Neural networks classify states which differ in neuronal activity levels using ensembles of neurons that increase/decrease their activity in each state. by Nicholas A. Frost (10739821)

“…As a result, there is an increase (neurons 51:100) or decrease (neurons 1:50) in activity levels in State B compared to State A. …”

<i>Vps34</i> KO MEFs show a decrease in LC3 conjugation and LC3 puncta formation upon starvation. by Kelly Devereaux (466106)

Supplemental data_Role of transient receptor potential vanilloid 4 in therapeutic anti-fibrotic effects of pirfenidone by Koji Kuronuma (9638138)