Loss of Fnip1 synergizes with loss of TSC1 resulting in accelerated PKD and mTOR activation. by Ryan Centini (5390768)

“…<p>(A) Kidney-to-brain ratio graph comparing double null (<i>Tsc1</i>^<i>fl/fl</i><i>Mb1</i>Cre⁺<i>Fnip1</i>^<i>-/-</i>), <i>Fnip1</i>^<i>-/-</i> (<i>Fnip1</i>^<i>-/-</i><i>Tsc1</i>^<i>fl/+</i> <i>Mb1</i>Cre-), <i>Tsc1</i> null (<i>Fnip1</i>^<i>-/+</i> <i>Tsc1</i>^<i>fl/fl</i><i>Mb1</i>Cre⁺), and heterozygous (<i>Fnip1</i>^<i>-/+</i> <i>Tsc1</i>^<i>fl/+</i> <i>Mb1Cre</i>^-) mice at 5 weeks of age, showing an increase in kidney size of double null mice at an early age. …”

<i>hse-5 loss of function</i> restores synaptic transmission in TDP-43 tg <i>C</i>. <i>elegans</i>. by Nicole F. Liachko (669572)

“…<p>(<i>A</i>) To assess neurodegeneration, GFP-labeled D-type GABAergic motor neurons were counted at L4 stage <i>in vivo</i> in living worms. …”

Increased lipid availability for three days reduces whole body glucose uptake, impairs muscle mitochondrial function and initiates opposing effects on PGC-1α promoter methylation i... by Roy Eldor (380760)

Table_2_SRSF1 acts as an IFN-I-regulated cellular dependency factor decisively affecting HIV-1 post-integration steps.docx by Helene Sertznig (9649127)

“…Type I interferons (IFN-I) play a crucial role in the innate immunity against HIV-1 by inducing the expression of IFN-stimulated genes (ISGs) including potent host restriction factors. …”

Table1_Research on the quality markers of antioxidant activity of Kai-Xin-San based on the spectrum–effect relationship.DOCX by Xiaoxiao Shan (8627850)

“…Combined with the results of GRA and OPLS-DA, peaks 1, 3, 5 (Sibiricose A6), 6, 13 (Ginsenoside Rg1), 15, and 24 in the fingerprints were screen out as the potential Q-makers of KXS for antioxidant effect. …”

Image_1_Lipidomics profiles of human spermatozoa: insights into capacitation and acrosome reaction using UPLC-MS-based approach.pdf by Xiaohong Cheng (275970)

“…While capacitation and the acrosome reaction, key processes before fertilization, involve substantial lipidomic alterations, a comprehensive understanding of the changes in human spermatozoa's lipidomic profiles during these processes remains unknown. …”

Image3_ATF4-dependent and independent mitokine secretion from OPA1 deficient skeletal muscle in mice is sexually dimorphic.tif by Jennifer Streeter (19729264)

“…</p>Methods<p>We generated mice with homozygous floxed Opa1 and Atf4 alleles and a tamoxifen-inducible Cre transgene controlled by the human skeletal actin promoter to enable simultaneous depletion of OPA1 and ATF4 in skeletal muscle (mAO DKO). …”

PGJ₂ inhibits WM related NFκB activity. by James D. Nicholson (292697)

“…<p>A. Ni-DAB quenched fluorescence analysis of NFκB expression and nuclear localization. …”

Gorlin syndrome-derived induced pluripotent stem cells are hypersensitive to hedgehog-mediated osteogenic induction by Daigo Hasegawa (4439164)

“…<div><p>Gorlin syndrome is an autosomal dominant inherited syndrome that predisposes a patient to the formation of basal cell carcinomas, odontogenic keratocysts, and skeletal anomalies. …”

DataSheet_1_Jianpi Huayu Decoction Attenuates the Immunosuppressive Status of H22 Hepatocellular Carcinoma-Bearing Mice: By Targeting Myeloid-Derived Suppressor Cells.pdf by Yingjie Xie (8459550)

“…Therefore, that the proportion of CD11b⁺Gr-1⁺ cells increased in the spleen of tumor-bearing hosts may not be villainy after treatment, when these drugs suppress the immunosuppressive ability of CD11b⁺Gr-1⁺ cells and promote it mature to replenish dendritic cell, at the same time. Generally, JHD may be a complementary and alternative drug for attenuating the immunosuppressive status induced by hepatocellular carcinoma, possibly by promoting differentiation and inhibiting the immunosuppressive activity of MDSCs.…”

Table_1_Brain Volumetric Alterations in Preclinical HIV-Associated Neurocognitive Disorder Using Automatic Brain Quantification and Segmentation Tool.DOCX by Ruili Li (470065)

“…No significant difference was found among preclinical HAND subgroups in all indices, and the difference between the individual groups (Not reach ANI and Cognitive integrity groups) and NCs was also insignificant. However, there was a significant difference between ANI and NCs in the relative volumes of the bilateral caudate and lateral ventricle.…”

Table_1_Healthy Serum-Derived Exosomes Improve Neurological Outcomes and Protect Blood–Brain Barrier by Inhibiting Endothelial Cell Apoptosis and Reversing Autophagy-Mediated Tight... by Lin-Yan Huang (6274160)

“…Intravenous serum-derived exosome treatment may, therefore, provide a novel clinical therapeutic strategy for ischemic stroke.…”

Table2_Isoquercitrin alleviates pirarubicin-induced cardiotoxicity in vivo and in vitro by inhibiting apoptosis through Phlpp1/AKT/Bcl-2 signaling pathway.XLSX by Lei Wang (6656)

“…Isoquercitrin (IQC) is a natural flavonoid with anti-oxidant and anti-apoptosis properties. …”

Data_Sheet_1_Sexual Dimorphisms of Protein-Coding Gene Profiles in Placentas From Women With Systemic Lupus Erythematosus.PDF by Hui-hui Li (12242504)

“…The results suggest that the SLE-dysregulated protein-coding genes in placentas may contribute to the pathophysiological progress of SLE pregnancies in a fetal sex-specific manner, leading to adverse pregnancy outcomes.…”

Video_7_Additional Improvement of Respiratory Technique on Vascular Function in Hypertensive Postmenopausal Women Following Yoga or Stretching Video Classes: The YOGINI Study.MOV by Cláudia Fetter (9315074)

“…</p><p>Study Design: Hypertensive postmenopausal women were recruited and randomized for 12 weeks, twice a week, of supervised yoga or stretching video classes of 75 min for 12 weeks associated or not with respiratory technique. …”

Different subregional metabolism patterns in patients with cerebellar ataxia by ¹⁸F-fluorodeoxyglucose positron emission tomography by Minyoung Oh (3639496)

“…<div><p>We evaluated cerebellar subregional metabolic alterations in patients with cerebellar ataxia, a representative disease involving the spinocerebellum. …”

Minimum data set used in the article. by Shizhen Xu (4474321)

“…It analyzed variation patterns of soil carbon, nitrogen, and phosphorus across different land-use types in the study area and explored the impacts of land-use types and seasonal climate fluctuations on these soil elements, aiming to provide a scientific basis for soil management. Results showed that during 2018–2019, the average organic carbon content in forestland soil (48.82 g/kg) was higher than that in grassland (38.32 g/kg) and cropland (30.80 g/kg). …”

Imaging c-Met expression using 18F-labeled binding peptide in human cancer xenografts by Weihua Li (144468)

“…<div><p>Objectives</p><p>c-Met is a receptor tyrosine kinase shown inappropriate expression and actively involved in progression and metastasis in most types of human cancer. …”

Table_2_Impact of BAFF Blockade on Inflammation, Germinal Center Reaction and Effector B-Cells During Acute SIV Infection.DOCX by Gwenoline Borhis (8518077)

“…From day 2 post-infection (dpi), Treated macaques received one weekly injection of BR3-Fc molecule, a soluble BAFF antagonist, for 4 weeks. Whereas, the kinetics of CD4⁺ T-cell loss and plasma viral loads were comparable in both groups, BAFF blockade delayed the peak of inflammatory cytokines (CXCL10, IFNα), impaired the renewal of plasmacytoid dendritic cells and fostered the decline of plasma CXCL13 titers after 14 dpi. …”

Image_1_Long Noncoding RNA X-Inactive-Specific Transcript Promotes the Secretion of Inflammatory Cytokines in LPS Stimulated Astrocyte Cell Via Sponging miR-29c-3p and Regulating N... by Mengqi Zhang (1580830)

“…</p>Results<p>XIST expression and NFAT5 protein level was increased, whereas miR-29c-3p expression was decreased in the epilepsy rat model and LPS-treated CTX-TNA2 cells. …”