PRISMA flow diagram for selection of studies. by Haribalakrishna Balasubramanian (21865971)

“…Compared to co-located care, transfer for surgery did not increase the odds of risk-adjusted and crude mortality in neonates with congenital diaphragmatic hernia [adjusted odds ratio (aOR):0.86 (0.49 to 1.49), 5 studies, 8366 infants; crude OR:0.68 (0.51 to 0.91, i.e., decreased mortality), 22 studies, 12970 infants], critical congenital heart disease [aOR:0.79 (0.42 to 1.48), 3 studies, 13485 infants; OR:1.04 (0.66 to 1.64), 10 studies, 14447 infants], surgical necrotizing enterocolitis [aOR:0.99 (0.61 to 1.61), 4 studies, 5891 infants; OR:1.03 (0.64 to 1.65), 5 studies, 5915 infants], gastroschisis [aOR:1.07 (0.68 to 1.68), 2 studies, 5294 infants; OR:0.80 (0.48 to 1.35), 11 studies, 8708 infants], tracheo-oesophageal fistula [aOR:0.97 (0.39 to 2.39), 1 study, 937 infants; OR:0.62 (0.37 to 1.04), 4 studies, 4050 infants], congenital or perinatal intestinal conditions [OR:2.69 (0.26 to 28.34), 4 studies, 1799 infants]. …”

Funnel plot for assessment of publication bias. by Haribalakrishna Balasubramanian (21865971)

“…Compared to co-located care, transfer for surgery did not increase the odds of risk-adjusted and crude mortality in neonates with congenital diaphragmatic hernia [adjusted odds ratio (aOR):0.86 (0.49 to 1.49), 5 studies, 8366 infants; crude OR:0.68 (0.51 to 0.91, i.e., decreased mortality), 22 studies, 12970 infants], critical congenital heart disease [aOR:0.79 (0.42 to 1.48), 3 studies, 13485 infants; OR:1.04 (0.66 to 1.64), 10 studies, 14447 infants], surgical necrotizing enterocolitis [aOR:0.99 (0.61 to 1.61), 4 studies, 5891 infants; OR:1.03 (0.64 to 1.65), 5 studies, 5915 infants], gastroschisis [aOR:1.07 (0.68 to 1.68), 2 studies, 5294 infants; OR:0.80 (0.48 to 1.35), 11 studies, 8708 infants], tracheo-oesophageal fistula [aOR:0.97 (0.39 to 2.39), 1 study, 937 infants; OR:0.62 (0.37 to 1.04), 4 studies, 4050 infants], congenital or perinatal intestinal conditions [OR:2.69 (0.26 to 28.34), 4 studies, 1799 infants]. …”

Sensitivity analysis. by Haribalakrishna Balasubramanian (21865971)

“…Compared to co-located care, transfer for surgery did not increase the odds of risk-adjusted and crude mortality in neonates with congenital diaphragmatic hernia [adjusted odds ratio (aOR):0.86 (0.49 to 1.49), 5 studies, 8366 infants; crude OR:0.68 (0.51 to 0.91, i.e., decreased mortality), 22 studies, 12970 infants], critical congenital heart disease [aOR:0.79 (0.42 to 1.48), 3 studies, 13485 infants; OR:1.04 (0.66 to 1.64), 10 studies, 14447 infants], surgical necrotizing enterocolitis [aOR:0.99 (0.61 to 1.61), 4 studies, 5891 infants; OR:1.03 (0.64 to 1.65), 5 studies, 5915 infants], gastroschisis [aOR:1.07 (0.68 to 1.68), 2 studies, 5294 infants; OR:0.80 (0.48 to 1.35), 11 studies, 8708 infants], tracheo-oesophageal fistula [aOR:0.97 (0.39 to 2.39), 1 study, 937 infants; OR:0.62 (0.37 to 1.04), 4 studies, 4050 infants], congenital or perinatal intestinal conditions [OR:2.69 (0.26 to 28.34), 4 studies, 1799 infants]. …”

Certainty of Evidence. by Haribalakrishna Balasubramanian (21865971)

“…Compared to co-located care, transfer for surgery did not increase the odds of risk-adjusted and crude mortality in neonates with congenital diaphragmatic hernia [adjusted odds ratio (aOR):0.86 (0.49 to 1.49), 5 studies, 8366 infants; crude OR:0.68 (0.51 to 0.91, i.e., decreased mortality), 22 studies, 12970 infants], critical congenital heart disease [aOR:0.79 (0.42 to 1.48), 3 studies, 13485 infants; OR:1.04 (0.66 to 1.64), 10 studies, 14447 infants], surgical necrotizing enterocolitis [aOR:0.99 (0.61 to 1.61), 4 studies, 5891 infants; OR:1.03 (0.64 to 1.65), 5 studies, 5915 infants], gastroschisis [aOR:1.07 (0.68 to 1.68), 2 studies, 5294 infants; OR:0.80 (0.48 to 1.35), 11 studies, 8708 infants], tracheo-oesophageal fistula [aOR:0.97 (0.39 to 2.39), 1 study, 937 infants; OR:0.62 (0.37 to 1.04), 4 studies, 4050 infants], congenital or perinatal intestinal conditions [OR:2.69 (0.26 to 28.34), 4 studies, 1799 infants]. …”

Characteristics of included studies. by Haribalakrishna Balasubramanian (21865971)

“…Compared to co-located care, transfer for surgery did not increase the odds of risk-adjusted and crude mortality in neonates with congenital diaphragmatic hernia [adjusted odds ratio (aOR):0.86 (0.49 to 1.49), 5 studies, 8366 infants; crude OR:0.68 (0.51 to 0.91, i.e., decreased mortality), 22 studies, 12970 infants], critical congenital heart disease [aOR:0.79 (0.42 to 1.48), 3 studies, 13485 infants; OR:1.04 (0.66 to 1.64), 10 studies, 14447 infants], surgical necrotizing enterocolitis [aOR:0.99 (0.61 to 1.61), 4 studies, 5891 infants; OR:1.03 (0.64 to 1.65), 5 studies, 5915 infants], gastroschisis [aOR:1.07 (0.68 to 1.68), 2 studies, 5294 infants; OR:0.80 (0.48 to 1.35), 11 studies, 8708 infants], tracheo-oesophageal fistula [aOR:0.97 (0.39 to 2.39), 1 study, 937 infants; OR:0.62 (0.37 to 1.04), 4 studies, 4050 infants], congenital or perinatal intestinal conditions [OR:2.69 (0.26 to 28.34), 4 studies, 1799 infants]. …”

Risk of bias assessment. by Haribalakrishna Balasubramanian (21865971)

“…Compared to co-located care, transfer for surgery did not increase the odds of risk-adjusted and crude mortality in neonates with congenital diaphragmatic hernia [adjusted odds ratio (aOR):0.86 (0.49 to 1.49), 5 studies, 8366 infants; crude OR:0.68 (0.51 to 0.91, i.e., decreased mortality), 22 studies, 12970 infants], critical congenital heart disease [aOR:0.79 (0.42 to 1.48), 3 studies, 13485 infants; OR:1.04 (0.66 to 1.64), 10 studies, 14447 infants], surgical necrotizing enterocolitis [aOR:0.99 (0.61 to 1.61), 4 studies, 5891 infants; OR:1.03 (0.64 to 1.65), 5 studies, 5915 infants], gastroschisis [aOR:1.07 (0.68 to 1.68), 2 studies, 5294 infants; OR:0.80 (0.48 to 1.35), 11 studies, 8708 infants], tracheo-oesophageal fistula [aOR:0.97 (0.39 to 2.39), 1 study, 937 infants; OR:0.62 (0.37 to 1.04), 4 studies, 4050 infants], congenital or perinatal intestinal conditions [OR:2.69 (0.26 to 28.34), 4 studies, 1799 infants]. …”

MIF induces proliferation of gastric and colon carcinoma cells. by Katherine T. Morris (286978)

“…<p>Tumor-derived gastric and colon supernatants induced proliferation of N87 and Caco-2 cells, which was decreased upon adding A) anti-MIF neutralizing antibodies or anti-CD74 blocking antibodies. …”

Tetracycline inhibiting the DNA binding activity of NF-κB. by Yongjun Jiang (122936)

“…(B) Levels of NF-κB DNA binding activity expressed as arbitrary densitometric units (A.U.) using Image J. Compared to the control group, NF-κB binding activity was significantly decreased in the tetracycline group. …”

NDPK stimulates growth in liquid medium. by Sarah J. Annesley (202479)

“…<p>The generation time for wild type and NDPK transformants was measured in three independent experiments and the mean for each transformant was plotted against the NDPK expression index (defined as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026024#pone-0026024-g005" target="_blank">Fig. 5</a>). …”

H₂S prevents pulmonary hypertension associated with O₂-induced lung injury. by Arul Vadivel (424484)

“…Representative echo Doppler and mean PAAT/RVET showing a characteristic notch indicating PHT (<b>arrow</b>) in hyperoxic-exposed rat pups and a significantly decreased PAAT/RVET as compared with rat pups housed in room air. …”

Navigational performance and reward checking during the auditory and visual virtual spatial navigation tasks. by Jesse D. Cushman (479673)

“…Two way ANOVA for effect target vs. other quadrants and auditory vs. visual trial types: Effect of quadrant F(1,8)  = 95.16, p< 0.001, Effect of task type: F(1,8)  = 2.08, p<0.001, Interaction of quadrant and task type: F(1,8)  = 2.08, p = 0.002; Effect of quadrant for auditory task: p = 0.097, target quadrant percentage occupancy: 23.9±0.5% vs. mean non-target occupancy: 25.36±0.17%, note that occupancy is slightly decreased in the target quadrant as animals entering the reward zone are teleported out; for visual task: p<0.001, target quadrant percentage occupancy: 59.6±1.15% vs. mean non-target occupancy: 13.5±0.38%, N = 5. …”

ESCRT-III constructs lead to inhibition of GLUT4 translocation to the cell surface of rat adipose cells. by Françoise Koumanov (305551)

“…(C) The PIKfyve inhibitor YM201636 decreases GLUT4 translocation to the cell surface in a dose dependent manner. …”

DataSheet1_Exposure-response analyses of efzofitimod in patients with pulmonary sarcoidosis.docx by Gennyne Walker (17085118)

“…</p><p>Results: In patients with pulmonary sarcoidosis, as efzofitimod exposure increased, the mean daily OCS dose decreased, and ppFVC and KSQ-Lung score improved over baseline. …”

Effects of medial ganglionic eminence (MGE) transplantation on seizure susceptibility and behavior in GAD65^-/- mice. by Jin Qi (206988)

“…Error bar = Mean ±SD. <b>C, D.</b> Latency to stress-induced seizures (sum of latencies at weeks 1–3 after transplantation) in mice that received MGE cell transplants was significantly correlated with total integration score (C, <i>r =</i> 0.025) and percentage area of GFP+ within the hippocampus (D, <i>r</i> = 0.007), suggesting a relationship between the success of the graft and decreased seizure susceptibility. …”

Comparison of differentially expressed genes. by Yongzhi Guo (295416)

“…Significant mean positive log2 fold changes corresponds to increased expression, whereas negative values corresponds to decreased expression. …”

Synergy between GPER1 and n-3 PUFAs in increasing MCF-7 cell cAMP-PKA signaling. by WenQing Cao (107805)

“…<p><b>A</b>. E2 increased intracellular cAMP in n-3 PUFA-treated MCF-7 cells. …”

CREB2 and LTM-dependent CAMEL activity. by Dominique Siegenthaler (7313987)

“…<p>(A) Expression of an inhibitory CREB2 isoform (CREB2b) significantly decreased the number of labeled CAMEL neurons (<i>n</i> ≥ 143). …”

Data_Sheet_1_Distribution of Polychlorinated Naphthalenes in Sediment From Industrialized Coastal Waters of Korea With the Optimized Cleanup and GC-MS/MS Methods.docx by Ha-Hyun Lee (11801360)

“…A clear decreasing gradient was observed for the sedimentary PCNs from inner to outer parts of the bays, streams, and rivers. …”

Table S1, S2, S3 and S4; Figure S1, S2,and S3 from An Allosteric PRC2 Inhibitor Targeting EED Suppresses Tumor Progression by Modulating the Immune Response by Hongping Dong (327340)

“…Primers used for quantitative Real-time RT-PCR; Supplementary Table 3. BR-A selectivity across a panel of kinases; Supplementary Table 4. …”

Diffusion Tensor Metrics as Biomarkers in Alzheimer's Disease by Julio Acosta-Cabronero (121892)

“…<div><h3>Background</h3><p>Although diffusion tensor imaging has been a major research focus for Alzheimer’s disease in recent years, it remains unclear whether it has sufficient stability to have biomarker potential. …”