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Divergent Biochemical Properties and Disparate Impact of Arrhythmogenic Calmodulin Mutations on Zebrafish Cardiac Function
Published 2024“…In cardiac muscle, CaM modulates directly or indirectly the activity of several proteins that play a key role in excitation-contraction coupling (ECC), such as ryanodine receptor type 2 (RyR2), l-type Ca2+ (Cav1.2), sodium (NaV1.5) and potassium (KV7.1) channels. Many recent clinical and genetic studies have reported a series of CaM mutations in patients with life-threatening arrhythmogenic syndromes, such as long QT syndrome (LQTS) and catecholaminergic polymorphic ventricular tachycardia (CPVT). …”
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VacoNet: Variable and connected architecture for data center networks
Published 2016“…In addition, VacoNet can reach even 50% in infrastructure cost reduction and the power consumption will be decreased with more than 50000 watt compared to all the previous architectures. …”
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467
Compressive And Tensile Strength Of Concrete Loaded And Soaked In Crude Oil
Published 2000“…Results show that the rate of crude oil absorption is high at early stages of soaking, but this rate decreases with time. There is a reduction in the absorption by 30 to 40 percent of ultimate strength in specimens exposed to instantaneous loading as compared with unloaded specimens. …”
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Detailed organic characterization of process water to evaluate reverse osmosis membrane fouling in industrial wastewater treatment
Published 2024“…After ACF treatment, the hydrophobic organics decreased to 0.65 mg/L, revealing that the ACF is removing >50 % of hydrophobic organics which are likely responsible for membrane fouling. …”
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Antimicrobial activity of amphiphilic nanomicelles loaded with curcumin against Pseudomonas aeruginosa alone and activated by blue laser light
Published 2021“…Among the three sublethal blue laser (λ 445 nm) protocols tested, the ones characterized by a fluence of 18 and 30 J/cm2 further decreased the antimicrobial concentration to 50 nM. …”
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The effect of acute ophiobolin A treatment on HO-mediated inflammatory processes
Published 2017“…After 24 h of the administrations, inflammatory mediators such as interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-) and myeloperoxidase (MPO) enzyme as well as heme oxygenase (HO) activity were measured in both plasma and cardiac tissue, along with serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST). We found that OPA caused a significant elevation in the concentrations of IL-6 and TNF-, increased MPO activity and decreased HO enzyme activity in the plasma. …”
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Therapeutic outcomes and biodistribution of gold nanoparticles in collagen-induced arthritis animal model
Published 2022“…CIA rats were then divided into five groups: CIA model (positive control), AuNPs treated- (sphere shape with size: 5, 25, and 75 nm), and methotrexate (MTX)-treated-rats. …”
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Burden of disease attributable to suboptimal diet, metabolic risks and low physical activity in Ethiopia and comparison with Eastern sub-Saharan African countries, 1990-2015: findi...
Published 2018“…While the age-adjusted proportion of all-cause mortality attributable to CMU decreased significantly between 1990 and 2015, it increased from 10.8% [95% UI: 8.8-13.3] to 14.5% [95% UI: 11.7-18.0] for dietary risks and from 17.0% [95% UI: 15.4-18.7] to 24.2% [95% UI: 22.2-26.1] for metabolic risks. …”
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Thermal and mechanical characterization of injection moulded high density polyethylene/paraffin wax blends as phase change materials
Published 2014“…The blends were prepared from 5 to 50vol. % of paraffin wax employing a twin-screw extruder. …”
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