AMPK activation reversed drug-induced hepatocellular injury. by Sun Woo Sophie Kang (3280878)

“…<p>Rat hepatocytes were treated with 10mM acetaminophen (APAP) or 250μM diclofenac (Diclo) for a period of 8 hours. Viabilities were measured every hour and time-courses of viability were analysed for (<b>A</b>) acetaminophen, and (<b>B</b>) diclofenac. …”

Downregulation of COP9 signalosome subunits differentially affects the CSN complex and target protein stability-5 by Andreas Peth (85734)

“…Whereas the anti-CSN5 antibody revealed a reduction to 23% as compared to the control, there was no decrease of the CSN complex observed with the anti-CSN8 antibody. …”

Data_Sheet_1_Hydroxyurea Scavenges Free Radicals and Induces the Expression of Antioxidant Genes in Human Cell Cultures Treated With Hemin.DOCX by Sânzio Silva Santana (9136571)

“…Significant increases in expression were observed in genes with kinase activity: protein kinase C beta (PRKCB), zeta (PRKCZ) and phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta (PIK3C2B). HU also induced a significant increase in expression of the gene p62/sequestosome (p62/SQSTM1) and a significant decrease in the expression of the transcriptional factor BACH1 in HUVECs. …”

Table 1_National estimates of mortality of unintentional drowning in China from 1990 to 2021 and its predicted level in the next decade: results from the global burden of disease s... by Liuqing You (8778278)

“…Epidemiological changes were the primary contributors to the observed decline in unintentional drowning deaths (decreased by 124985.81). The ASMR of unintentional drowning would continue to decrease slowly at the national level and that the decreasing trends would be stable in the future.…”

Table_2_Global burden of drug use disorders by region and country, 1990–2021.docx by Shuyan Zhang (426593)

“…</p>Results<p>The global ASIR of DUDs showed a slight downward trend (EAPC = −0.26). The age-standardized DALY rate (per 100,000) significantly declined from 1990 to 2021 (EAPC = −1.44). …”

Sex hormone stimulation of CRISPR-modified HepG2 cells alters alpha-1 antitrypsin production by Emma Leacy (11872358)

“…</p><p dir="ltr"><b>Results:</b> Both hormones significantly reduced intracellular AAT (Figure 1A), even at low concentrations. There was also a dose-dependent decrease in AAT release, particularly in oestrogen-treated cells (Figure 1C). …”

Table_1_Chromatic pupillometry isolation and evaluation of intrinsically photosensitive retinal ganglion cell-driven pupillary light response in patients with retinitis pigmentosa.... by He Zhao (754174)

“…We aimed to isolate ipRGC-driven pupil responses using chromatic pupillometry and to determine the effect of advanced retinitis pigmentosa (RP) on ipRGC function.</p>Methods<p>A total of 100 eyes from 67 patients with advanced RP and 18 healthy controls (HCs) were included. …”

Table_1_The spatial and temporal distribution of China’s forest carbon.DOCX by Fushan Cheng (14648102)

“…Introduction<p>China’s forests have sequestrated a significant amount of carbon over the past two decades. …”

Image_2_Clinical study on sequential treatment of severe diarrhea irritable bowel syndrome with precision probiotic strains transplantation capsules, fecal microbiota transplantati... by Linling Lv (12261320)

“…</p>Results<p>It was found that the IBS-SSS score of patient case 1 decreased by 175 points and that of patient case 2 decreased by 100 points after treatment of precision probiotic strains transplantation capsules. …”

Presentation_1_Stay-at-home and face mask policy intentions inconsistent with incidence and fatality during the US COVID-19 pandemic.pdf by Samuel X. Wu (13954158)

“…States with SAH orders showed a potential 50–60% decrease in infection and fatality during the SAH period (about 45 days). …”

Data_Sheet_1_Novel Quorum Quenching YtnP Lactonase From Bacillus paralicheniformis Reduces Pseudomonas aeruginosa Virulence and Increases Antibiotic Efficacy in vivo.pdf by Lidija Djokic (12716498)

“…<p>Bacterial infections have become increasingly difficult to treat due to the occurrence of antibiotic-resistant strains. A promising strategy to increase the efficacy of therapy is to combine antibacterials with agents that decrease pathogen virulence via the modulation of the quorum sensing (QS). …”

Intestinal Microbial Metabolites Are Linked to Severity of Myocardial Infarction in Rats by Vy Lam (274720)

“…Hierarchical clustering of dissimilarities separated the levels of 284 identified metabolites from treated vs. untreated rats; 193 were altered by the antibiotic treatments with a tendency towards decreased metabolite levels. …”

Table_1_Global burden of drug use disorders by region and country, 1990–2021.docx by Shuyan Zhang (426593)

“…</p>Results<p>The global ASIR of DUDs showed a slight downward trend (EAPC = −0.26). The age-standardized DALY rate (per 100,000) significantly declined from 1990 to 2021 (EAPC = −1.44). …”

Shannon Diversity Scores. by Brittany E. Goldberg (765746)

“…Most patients had scores greater than 5.6. The sole exception was patient 12, who was the only patient under age five. …”

Evolution of the fraction of global infection with a non-linear trade-off. by Koich Saeki (4797375)

“…<p>(a) A linear trade-off between the degree of global infection <i>G</i> (horizontal axis) and that of local infection <i>L</i> (vertical axis) assumed so far (dashed curve), and a non-linear trade-off examined here (solid curve), where the local infection decreases in proportional to . (b) Pairwise invasibility plot with <i>x</i>_<i>C</i> = 0.5, <i>p</i>_<i>CC</i> = 0.4, <i>α</i> = 1, <i>β</i>_<i>G</i> = <i>β</i>_<i>L</i> = 10. …”

Figure 4. Transcriptional effects of SOX15 perturbation. by Merrick Pierson Smela (7036586)

<i>Spathiphyllum</i> dark adaptation filter wheel spectral analysis. by Carl L. Oros (5395787)

“…Solid black line is the non-normalized, 5-point smoothed adjacent average photocount data. …”

Carnosine treatment has sub-maximal effect in counteracting memory deficits in 3xTg-AD mice. by Carlo Corona (354704)

“…All the three groups showed no short-term memory impairment as assessed by MWM performance at 1.5 h. When tested for long-term memory deficits at 24 h, untreated 3xTg-AD mice exhibited a significant deficit in their performance as assessed by the marked increase in the time (latency) they employed to reach the point where the platform used to be. …”

DataSheet_1_Pro- and Anti-Inflammatory Responses in Severe COVID-19-Induced Acute Respiratory Distress Syndrome—An Observational Pilot Study.docx by Quirin Notz (4269991)

“…This coincided with a slight increase in anti-SARS-CoV-2-Spike-RBD immunoglobulin (Ig) G and a decrease in anti-SARS-CoV-2-Spike-RBD IgM. …”

Hypokalemia, Its Contributing Factors and Renal Outcomes in Patients with Chronic Kidney Disease by Hsiao-Han Wang (429124)

“…Hyperkalemia defined as sK >5 mEq/L conferred 1.6-fold (95% CI,1.09–2.34) increased risk of ESRD compared with sK = 4.5–5 mEq/L. …”