Data_Sheet_3_Tfam Knockdown Results in Reduction of mtDNA Copy Number, OXPHOS Deficiency and Abnormalities in Zebrafish Embryos.PDF by Auke B. C. Otten (8965244)

“…Morphant embryos displayed abnormal development of the eye, brain, heart, and muscle, as well as a 50 ± 22% decrease in ATP production. Transcriptome analysis revealed a decrease in protein-encoding transcripts from the heavy strand of the mtDNA, and down-regulation of genes involved in haem production and the metabolism of metabolites, which appear to trigger increased rRNA and tRNA synthesis in the nucleoli. …”

Data_Sheet_2_Tfam Knockdown Results in Reduction of mtDNA Copy Number, OXPHOS Deficiency and Abnormalities in Zebrafish Embryos.pdf by Auke B. C. Otten (8965244)

“…Morphant embryos displayed abnormal development of the eye, brain, heart, and muscle, as well as a 50 ± 22% decrease in ATP production. Transcriptome analysis revealed a decrease in protein-encoding transcripts from the heavy strand of the mtDNA, and down-regulation of genes involved in haem production and the metabolism of metabolites, which appear to trigger increased rRNA and tRNA synthesis in the nucleoli. …”

Data_Sheet_4_Tfam Knockdown Results in Reduction of mtDNA Copy Number, OXPHOS Deficiency and Abnormalities in Zebrafish Embryos.PDF by Auke B. C. Otten (8965244)

“…Morphant embryos displayed abnormal development of the eye, brain, heart, and muscle, as well as a 50 ± 22% decrease in ATP production. Transcriptome analysis revealed a decrease in protein-encoding transcripts from the heavy strand of the mtDNA, and down-regulation of genes involved in haem production and the metabolism of metabolites, which appear to trigger increased rRNA and tRNA synthesis in the nucleoli. …”

Inhibition of Cav3 binding affects Ca²⁺ homeostasis, cytoskeletal-membrane interactions and MSC activity. by Haixia Huang (452278)

“…Addition of 5 mM MβCD did not induce a Ca²⁺ response. …”

S1 File - by Idika E. Okorie (11350612)

Disruption of EAE pathogenesis by B cell depletion. by Nancy L. Monson (121113)

“…Disease course of WTLM and hCD20Tg mice, EAE onset and severity was monitored using a 5-point scale. Shown are the mean clinical score +/− SEM. …”

Time (seconds) needed to complete one update of all coordinates and to reach convergence in sets of gene expression data from blood disorders. by Leo Taslaman (300585)

Figure S1 - Contingent Kernel Density Estimation by Scott Fortmann-Roe (24544)

“…A uniform contingency distribution was assumed for each point with radiuses of, respectively, 1, 2, 0.3, 4 and 2.5. …”

Intracellular perfusion of astrocyte with inhibitors of vesicular transport of ATP selectively affects slower purinergic EPSCs. by Ulyana Lalo (506296)

“…Each dot shows the average amplitude and frequency of spontaneous currents recorded in a 1 min time window in the pyramidal neurons during perfusion of astrocyte with AlexaFluor 488 only (contro) and AlexaFluor and AP3A; data are presented as mean ± SD for five neurons. …”

Depletion of TGF-β alters morbidity in HK/486-infected mice. by Christina M. Carlson (240307)

“…<p>Six hours before infection, BALB/c mice were treated with a TGF-β neutralizing antibody (1D11) or an isotype control antibody (IgG) at a dose of 0.5 mg/mouse and subsequently inoculated with PBS (control) or 10⁵ TCID₅₀ units of HK/486 virus (n = 15). …”

Changes in cell adhesion and in neuronal morphology induced by sAPPα, sAPPβ and sAPP-Fc added to neurons after 1 DIV. by Stéphanie Chasseigneaux (231744)

“…(<b>C–E</b>) Morphometric analysis 96 hours after the addition of sAPPs (50 to 150 nM) to 1DIV primary neurons. (C) At 50 and 100 nM sAPPα and sAPPβ induce a significant decrease of primary dendrite length while at 150 nM, the decrease in primary dendrite length is still significant for sAPPβ only (50 nM: control (Ctrl) vs sAPPα: p<0.0001, control vs sAPPβ: p<0.0001; 100 nM: control vs sAPPα: p<0.0001, control vs sAPPβ: p<0.0001; 150nM: control vs sAPPα: NS, control vs sAPP-Fc: NS, sAPPα vs sAPP-Fc: NS, control vs sAPPβ: p<0.0001). …”

Supplementary Material for: Selective Serotonin Reuptake Inhibitors and Serotonin Noradrenaline Reuptake Inhibitors withdrawal changes DSM presentation of mental disorders: Results... by Cosci F. (4134769)

“…Using a new nosographic classification of withdrawal syndromes due to SSRI/SNRI decrease or discontinuation (by Chouinard and colleagues), we explored whether DSM is adequate to identify DSM disorders when withdrawal occurs. …”

Soy isoflavones genistein and daidzein protect primary cortical cultures from Tat neurotoxicity. by Sheila M. Adams (322032)

“…Live/Dead ratios were determined after 48 hr (<b>A-C</b>) or 5 days (<b>D-F</b>) of the continuous exposure to Tat or equal volume of vehicle in cell culture groups that were treated or not treated with estrogen, GEN, or DAI. …”

Supplementary Material for: Clinical Utility of KidneyIntelX in Early Stages of Diabetic Kidney Disease in the CANVAS Trial by Lam D. (11931392)

“…During a mean follow-up of 5.6 years, 131 participants (9.9%) experienced the composite kidney outcome. …”

Effect of the manipulation of host cell TfR1 expression on <i>E</i>. <i>hellem</i> infection. by Bing Han (38992)

“…A significant decrease in infection was observed in HFF treated with human TfR1.…”

<b>Study of the best prediction model for the effectiveness of subcutaneous immunotherapy in childhood asthma patients</b> by Qiuyan Yang (14760943)

“…The average accuracy reduction of the random decision forest model at the 9th month for DMS (mean decrease in accuracy, MDA) was 11.77, and the model importance for VAS score in 9th month in the XG-Boost model was 0.121. …”

Determination of the CbiY flavin midpoint redox potentials. by Hannah F. Collins (282149)

“…Panel B show a data fit at the sq/hq isosbestic point (430 nm), yielding a value of <i>E</i>₁ = −92±5 mV, while panel D shows the respective data fit at the ox/sq isosbestic point (487 nm), yielding a value of <i>E</i>₂ = −149±3 mV.…”

VEGFR1 and VEGFR2 Involvement in Extracellular Galectin-1- and Galectin-3-Induced Angiogenesis by Nicky D'Haene (422477)

Parasympathetic blockade by methylatropine prevents bradycardia during seizure and in the immediate post-ictal period. by William P. Schilling (7522238)

“…<b>D:</b> The change in heart rate for individual mice in the absence of methylatropine is shown. Note the rapid decrease in heart rate in the clonic period with a further decrease by the end of the tonic period. …”

Figure CSA-2 4.12 by CIMR project (7352015)

“…<div><br></div><div>These panels show a comparison of mean error between "perfect" (no added error) all IR sensor data (red) and IR + CIMR data (blue) for a 15-day period in January compared with a "truth" model dataset.…”