The Wobbler Mouse Model of Amyotrophic Lateral Sclerosis (ALS) Displays Hippocampal Hyperexcitability, and Reduced Number of Interneurons, but No Presynaptic Vesicle Release Impair... by Karina D. Thielsen (496092)

“…This study reveals that the wobbler mouse model of ALS exhibits hippocampal hyperexcitability. We suggest that the hyperexcitability could be caused by increased excitatory synaptic transmission and a concomitant reduced inhibition due to a decreased number of parvalbumin positive interneurons. …”

Data Sheet 1_Long-term outcomes according to absolute value vs. percentage reduction in low-density lipoprotein cholesterol levels after acute myocardial infarction.pdf by Kyung Hoon Cho (12176516)

“…In the analysis of the percentage LDL-C reduction from baseline, greater reductions were associated with lower MACE risk. In a multivariable Cox time-to-event analysis with LDL-C < 50% reduction from baseline as the reference, ≥50% LDL-C reduction from baseline was independently associated with a decreased incidence of MACE (adjusted hazard ratio, 0.76; 95% confidence interval, 0.62–0.92).…”

Data Sheet 1_Exploratory study on the ascending pain pathway in patients with chronic neck and shoulder pain based on combined brain and spinal cord diffusion tensor imaging.docx by Zhiqiang Qiu (4603993)

“…</p>Results<p>Compared to HCs, CNSP patients showed decreased mean FA values and increased mean MD values in bilateral intracranial STT compared to the HC group, but two-sample t-test results indicated no statistically significant differences (p > 0.05). …”

Modeling Electrophysiological Coupling and Fusion between Human Mesenchymal Stem Cells and Cardiomyocytes by Joshua Mayourian (3148134)

“…The third family of hMSCs (Type C), absent of hEAG1 activity, led to smaller single-cell action potential alterations during coupling and fusion, translating to longer tissue-level mean action potential wavelength. In a simulated 2-D monolayer of cardiac tissue, re-entry vulnerability with low (5%) hMSC insertion was approximately eight-fold lower with Type C hMSCs compared to hEAG1-functional hMSCs. …”

HCl-gas etching behavior of (001) β-Ga₂O₃ under oxygen supply by Yuichi Oshima (19232291)

“…At 747°C, the planar etch rate (PER) exhibited a slight decrease with increasing <i>P</i>⁰(O₂). …”

Data_Sheet_3_Cardiorespiratory Alterations in a Newborn Ovine Model of Systemic Inflammation Induced by Lipopolysaccharide Injection.PDF by Stéphanie Nault (846680)

“…LPS injection decreased locomotor activity (p = 0.03) and active wakefulness (p = 0.01) compared to the CTRL. …”

Effects of azilsartan compared with telmisartan on insulin resistance in patients with essential hypertension and type 2 diabetes mellitus: An open-label, randomized clinical trial by Mitsuhide Naruse (6551468)

“…Only one drug-related TEAE (mild decrease in blood pressure) was reported in one patient in the azilsartan group.…”

Serum IL-1Ra from intra-colonic inhibits IL-1-induced thymocyte proliferation by Stefano Porzio (5085)

“…Results are presented as mean ± SEM of triplicate cultures within single representative experiments. …”

Data_Sheet_1_Preclinical Studies Comparing Efficacy and Toxicity of DNA Repair Inhibitors, Olaparib, and AsiDNA, in the Treatment of Carboplatin-Resistant Tumors.pdf by Nirmitha I. Herath (7848288)

“…</p><p>Results: Olaparib or AsiDNA monotherapies decreased tumor growth and increased mean survival of grafted animals. …”

Averaged 24-activity profiles for all control and MPTP-treated monkeys with individual traces for all recordings (n = 39 assays) in LD (upper panel) and in LL (lower panel) conditi... by Karim Fifel (208382)

“…The reduction of TH immunostaining in the mesencephalon of MPTP-treated monkeys (<b>C₅</b>, 65%, <b>C₆</b>, 72%, <b>C₇</b>, >80%) compared to a control (<b>C₄</b>). a: Substantia nigra (SN); b: Ventral tegmental area (VTA), Scale bar: 1000 µm.…”

Image_1_Ten-Year Legacy Effects of Three Eight-Month Exercise Training Programs on Cardiometabolic Health Parameters.JPEG by Johanna L. Johnson (6591113)

“…Original participation in either the moderate intensity exercise or control group resulted in a 10.5% decrease in peak VO₂ over the ensuing 10 years. …”

Image_1_Effects of a Short-Term Resistance-Training Program on Heart Rate Variability in Children With Cystic Fibrosis—A Randomized Controlled Trial.tif by Agustín Jesús Estévez-González (10495067)

“…Individuals in the EX group completed an individualized guided resistance program (5-RM—60–80%) for 8 weeks (3 sessions of 60 min/week). …”

Localization of anti-TG2 scFvs after intraventricular delivery and footprint analysis. by Sabrina Boscolo (251883)

“…Mice treated with monoclonal antibodies were tested at 5 h, after antibody injection for gait imbalance with footprint analysis. …”

dCas9-KR induced DNA damage does not increase INDELs or mutations. by Nealia C. M. House (9867105)

“…Template integrity after illumination is expressed as a percent decrease in the quantified qPCR signal from paired, unilluminated cells. …”

Table_1_Estimation of climate-induced increased risk of Centaurea solstitialis L. invasion in China: An integrated study based on biomod2.DOCX by Tao Jia (756099)

“…</p>Methods<p>In this study, based on 5,969 valid occurrence records of C. solstitialis and 33 environmental variables, we constructed an ensemble model to predict suitable habitats for C. solstitialis under climate change scenarios.…”

Supplementary file 1_Efficacy and safety of Chinese herbal medicine for multiple sclerosis: a systematic review and meta-analysis of randomized controlled trials.docx by Xiaorui Guan (13542919)

“…This was evidenced by a decrease in the EDSS (mean difference (MD) = −0.65; 95% confidence interval (CI): −0.96, −0.35; P < 0.0001; MD = −0.65, ARR (relative risk (RR) = 0.48; 95% CI: 0.31, 0.73; P = 0.0007), neurological signs scores (MD = −2.96; 95% CI: −4.52, −1.39; P = 0.0002), and MFIS (MD = −8.55; 95% CI: −10.20, −6.89; P < 0.00001). …”

DataSheet1_Soil Surface Micro-Topography by Structure-from-Motion Photogrammetry for Monitoring Density and Erosion Dynamics.docx by Annelie Ehrhardt (11954732)

“…The micro-topographical changes resulting from rainfall–induced soil mass redistribution within the plots were determined from the differences in SfM maps before and after rain. The largest decrease in mean soil surface elevation and roughness was observed after rain for the middle slope plot and primarily in initially less compacted regions. …”

Supplementary materials: Impact of surgical complications on hospital costs and revenues: retrospective database study of Medicare claims by Samer Haidar (18368156)

“…</li><li><b>Table A2: </b>Matched dataset balance diagnostics. Standardized mean differences. No complications (control) versus complications.…”

S1 File - An updated vocal repertoire of wild adult bonobos (<i><i>Pan paniscus</i></i>) by Franziska Wegdell (9736095)

“…Unsupervised random forest approach. S4 Fig. Influence (mean decrease accuracy) each acoustic parameter has on the random forest model. …”

The Effect of a Physical Activity Program on the Total Number of Primary Care Visits in Inactive Patients: A 15-Month Randomized Controlled Trial by Maria Giné-Garriga (424793)

“…One hundred and eighty-three patients (n = 183; mean (SD); 68.3 (8.8) years; 118 women) were randomly allocated to the physical activity program (IG). …”