MicroRNA-3148 Modulates Allelic Expression of Toll-Like Receptor 7 Variant Associated with Systemic Lupus Erythematosus by Yun Deng (67804)

“…These data establish rs3853839 of <i>TLR7</i> as a shared risk variant of SLE in 22,613 subjects of Asian, EA, AA, and Amerindian/Hispanic ancestries (<i>P_meta</i> = 2.0×10⁻¹⁹, OR = 1.25 [1.20–1.32]), which confers allelic effect on transcript turnover via differential binding to the epigenetic factor miR-3148.…”

Bortezomib reduced viral load and signs of dengue pathology in C57BL/6 mice. by Milly M. Choy (790882)

“…On the other hand, no significant changes were observed for the platelet count 24–72 hpi, and hematocrit levels 0–72 hpi in mice after bortezomib treatment, suggesting the efficiency of bortezomib in alleviating disease symptoms. Mean ± SEM. N = 4–5. Student’s t test, *p<0.05, ****p<0.0001. (F-G) DENV2-infected vehicle control displayed an increased systemic level of MCPT1, indicative of mast cell activation, in mouse serum and spleen when compared to bortezomib treated mice at all time-points. …”

Late Mesozoic tectonic affinity of the Tengchong Block and southward extension of the Bangong-Nujiang Suture: constraints from Early Cretaceous granitic rocks in western Yunnan, SW... by Chen Wang (88408)

“…Nb, Ta, P, Ti), and have negative apatite ε_Nd(t) values (−10.4 to −6.7) and negative zircon ε_Hf(t) values (−11.7 to −1.2). …”

Model Studies of Methacrylate Chain Transfer Polymerization Mediated by Cationic Zirconocene <i>tert</i>-Butyl Enolate by Bing Lian (1915672)

“…In this case, a moderate decrease in the molecular weight of the PMMAs is observed. …”

Table_1_ECG-Based Indices to Characterize Persistent Atrial Fibrillation Before and During Stepwise Catheter Ablation.docx by Anna McCann (10495724)

“…Temporal evolution of these measures was assessed using a statistical test for mean value transitions, as an indicator of changes in AF organization. …”

Rhabdomeral localization of Rh1 and TRP is not affected in the <i>ttd14</i>^<i>P75L</i> mutant. by Alexander C. Cerny (819175)

“…<p>(A) Water immersion microscopy images of the Rh1-eGFP and TRP-eGFP fluorescence in the eyes of wild type flies (wild type) and <i>ttd14</i>^<i>P75L</i> mutant eye clones (<i>ttd14</i>^<i>P75L</i>). …”

Dibucaine lessens dendritic beading induced by spontaneous spreading depolarizations (SDs) in penumbra. by W. Christopher Risher (213699)

“…Densities were assessed from random 30 µm segments of 3 dendrites in each imaging field as observed in maximum intensity projections of three-dimensional stacks in 5 control and 8 dibucaine treated mice. Data points (representing averages taken from individual dendrites) were only used when an image was taken near the peak of a recorded spreading depolarization. …”

Table_1_Neutrophil Extracellular Traps in SARS-CoV2 Related Pneumonia in ICU Patients: The NETCOV2 Study.DOCX by Mathieu Godement (10180910)

“…The blood level of NETs significantly decreased between day-1 and day-3 in patients who survived (59.5 [30.5, 116.6] to 47 [33.2, 62.4] p = 0.006; 8.6 [3.4, 18.0] to 4 [1.4, 10.7] p = 0.001 and 7.4 [4.0, 16.7] to 2.6 [1.0, 8.3] p = 0.001 for MPO+, Cit-H3+, and MPO+ Cit-H3+ NETs, respectively) while it remained stable in patients who died (38.4 [26.0, 54.8] to 44.5 [36.4, 77.7] p = 0.542; 4.9 [1.3, 13.0] to 5.5 [2.8, 6.9] p = 0.839 and 4 [1.3, 13.6] to 2.7 [1.4, 4.5] p = 0.421 for MPO+, Cit-H3+, and MPO+ Cit-H3+ NETs, respectively). …”

Data_Sheet_1_Fully Integrated PET/MR Imaging for the Assessment of the Relationship Between Functional Connectivity and Glucose Metabolic Rate.PDF by Lalith Kumar Shiyam Sundar (8622243)

“…Discussion: Measurement of functional connectivity within established brain networks did not provide a means to decrease the inter- or intrasubject variability of CMRGlc values. …”

Red Blood Cell Transfusion and Mortality in Trauma Patients: Risk-Stratified Analysis of an Observational Study by Pablo Perel (102217)

“…For this analysis the exposure considered was RBC transfusion, and the main outcome was death from all causes at 28 days. A total of 10,227 patients (50.8%) received at least one transfusion. …”

Formation of ¹O₂ and H₂O₂ during experiments in 2006, 2008 and 2009. by Stefanie P. Glaeser (542828)

“…A. 12^nd July 2006: a clear sky during the afternoon led to a steady decrease in [¹O₂]_SS concentrations from noon to late afternoon. …”

Primary and secondary outcomes. by Axel Cosmus Pyndt Diederichsen (3134508)

“…<div><p>Background</p><p>The Danish cardiovascular screening (DANCAVAS) trial, a nationwide trial designed to investigate the impact of cardiovascular screening in men, did not decrease all-cause mortality, an outcome decided by the investigators. …”

Safety outcomes. by Axel Cosmus Pyndt Diederichsen (3134508)

“…<div><p>Background</p><p>The Danish cardiovascular screening (DANCAVAS) trial, a nationwide trial designed to investigate the impact of cardiovascular screening in men, did not decrease all-cause mortality, an outcome decided by the investigators. …”

Enrolment, randomisation, and follow-up. by Axel Cosmus Pyndt Diederichsen (3134508)

“…<div><p>Background</p><p>The Danish cardiovascular screening (DANCAVAS) trial, a nationwide trial designed to investigate the impact of cardiovascular screening in men, did not decrease all-cause mortality, an outcome decided by the investigators. …”

Mild hyperthermia treatment enhances particle inflow and localization in breast tumor models. by Dickson K. Kirui (523816)

“…<p>A) SEM micrograph of porous MSVs (1000×400 nm) that allow therapeutic loading; B, C) Time-lapse quantification analyses of fluorescently-labeled MSVs in tumor vasculature showing increased initial and total number MSVs in tumors receiving MHT treatment versus control groups. 5-fold enhancement was observed in SUM159 and 3-fold for MCF7; D) Representative time-lapse images from videos acquired over 60 min, showed decreased number of MSVs with time and adherent particles shown after 60 min. …”

File contains the zipped set of figures for this paper in PNG format. by Piotr Borkowski (15195012)

“…S4_14_Fig.png: Effects of similarity perturbation within a class of data. Upper line represents the maximal quotient and the lower line represents the minimal quotient of eigenvalues after and before perturbing the similarity matrix, as described in the text, depending on the maximal similarity decrease factor. …”

iNTS_QECH_2011-2019_aggregate_age.docx by Catherine Wilson (8586315)

“…Between 2011-2019 there was a substantial decrease in proportion of <i>S.</i> Typhimurium (78.5% to 27.7%) and <i>S. …”

<i>Oxtr</i> promoter methylation changes <i>in vivo</i>. by Shimrat Mamrut (283008)

“…<b>C</b>) The mean difference in the methylation of the seven examined CpG sites, between early postpartum and virgin females. A general increase is observed in the mammary glands while a general decrease is evident in the uterus. …”

Table_1_Canagliflozin alters the gut, oral, and ocular surface microbiota of patients with type 2 diabetes mellitus.docx by Limin Wang (87511)

“…</p>Clinical parameters<p>A significant decrease in fasting plasma glucose (8.22 ± 2.19 vs 6.87 ± 1.09 mmol/L), glycated serum protein [291.00 (264.00, 353.00) vs 275.00 (251.00, 342.50) μmol/L], hemoglobin A1c (7.39 ± 1.18 vs 7.12 ± 1.33%), body mass index (25.32 ± 2.99 vs 24.83 ± 2.95 kg/m²), systolic blood pressure (129.05 ± 17.51 vs 123.43 ± 14.82 mmHg), and urinary creatinine [158.40 (74.75, 219.15) vs 79.70 (56.25, 138.10) μmmol/kg] levels was noted after 30-day Cana monotherapy (P < 0.05).…”

Related to Fig 3. Neither <i>Catalase</i> nor <i>Sod1</i> overexpression restore cytoskeletal loops to <i>NDUFS7</i>-deficient animals. by Bhagaban Mallik (12459375)

“…Raw data for this figure are available in the <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3003388#pbio.3003388.s003" target="_blank">S2 Data</a> Excel file, tab S9 Fig.…”