PKCε activation induces aggrecan gene expression, decreases ADAMTS5, and detection of ADAMTS-5-depended cleavage of ECM aggrecan through upregulation of hsa-miR-377 expression. by Emmanouella Tsirimonaki (490707)

“…<p>(<b>A</b>) RT-PCR detected the relative expression of ACAN, MKI67, ADAMTS5 after treatment of NP cells with 1 μM ψεRACK (or vehicle) for indicated times and revealed that time-dependent activation of PKCε significantly increased the mRNA expression for aggrecan, while in an opposing manner decreased ADAMTS5; mRNA levels of the proliferation marker Ki67 became barely detectable after 8 hours of PKCε activation. …”

Effects of a DCL on the number of 50-kHz USVs induced by rhythmic stroking. by Rie Shimoju (20940045)

Image_1_IL-12p40/IL-23p40 Blockade With Ustekinumab Decreases the Synovial Inflammatory Infiltrate Through Modulation of Multiple Signaling Pathways Including MAPK-ERK and Wnt.TIF by Renée H. Fiechter (10230473)

“…</p><p>Objectives: To investigate the cellular and molecular pathways affected by IL-12p40/IL-23p40 blockade with ustekinumab in the synovium of PsA patients.</p><p>Methods: Eleven PsA patients with at least one inflamed knee or ankle joint were included in a 24-week single-center open-label study and received ustekinumab 45 mg/sc according to standard care at week 0, 4, and 16. …”

Scallop fishery landings from RCP8.5 (top panel) and RCP4.5 (bottom panel) under the highest management strategy (catch limits, variable reference points, and 10% area closure) with varying ocean acidification impacts: Decreased larval survival (L), reduced growth rates (L+G), and increased predation on small scallops (L+G+P). by Jennie E. Rheuban (735526)

Cytotoxicity (as of %Control) IC₅₀ value (mean ±SD in µM) of the tested compounds vs. positive controls Cisplatin and doxorubicin against other malignancy’ cell lines ad... by MohammedBashar Al-Qazzan (22439236)

Time dependent activation of the pulmonary inflammatory response. by Marc-Alexander Oestreich (13961375)

Fig 2 - by Lukas E. Brümmer (11269299)

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Dehydrozingerone Improves Mood and Memory in Diabetic Mice via Modulating Core Neuroimmune Genes and Their Associated Proteins by Anuradha Kesharwani (21386000)

Subjects:

PRISMA flow diagram. by Lukas E. Brümmer (11269299)

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Typical fit of V Kα spectrum using only five scaling parameters, yielding two calibration points (V Kα₁ and V Kα₂ which constrain the spectrometer dispersion... by C T Chantler (557430)

“…</strong> Typical fit of V Kα spectrum using only five scaling parameters, yielding two calibration points (V Kα₁ and V Kα₂ which constrain the spectrometer dispersion function). …”

The %change in GABA level had a trend correlation with MEP amplitude in the left sensorimotor area (R = −0.43002, R2 = 0.1849, t = 1.844717, p = 0.082575). by Hiroyuki Matsuta (13250169)

Quantification of <i>ATP5B</i> mRNA and β-F1-ATPase protein expression shows decreased protein translation in obesity. by Lee Tran (2106961)

Pretreatment of Huh-7.5.1 cells with PF-429242 results in a dose-dependent decrease in intracellular DENV-2 NS1 protein abundance and a 3-log decrease in extracellular viral titer. by Anastasia Hyrina (3860455)

Decreasing cell adhesion decreases [Ca²⁺]_i oscillation frequency. by Charles Godbout (540424)

Decreased Aβ oligomer immunoreactivity in APPxPS1 mice after treatment with hNGFP61S/R100E: polyclonal pAb A11 antibody. by Simona Capsoni (161132)

Overidentification test results. by Pu Miao (12886949)

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L-[1-¹⁴C]Met oxidation as a percentage of dose, representing the change in Cys synthesis, in enterally fed piglets receiving graded levels of Cys and 0.25 g kg<sup>-1</s... by Anna K. Shoveller (6208457)

Occurrences of the hemoglobin safety composite endpoint (hemoglobin decrease of ≥40 g/L or ≥40% versus baseline or hemoglobin <50 g/L or blood transfusion) by G6PD genotype in the... by Zul Premji (215008)

Intracellular elemental composition of <i>S</i>. <i>cerevisiae</i> BH8 before (a) and after (b) cultivated in MSM with 1.50 mM Cu²⁺ for 48h. by Xiang-yu Sun (748032)

To be funny or not to be funny: Gender differences in student perceptions of instructor humor in college science courses by Katelyn M. Cooper (5634851)

“…<div><p>For over 50 years instructor humor has been recognized as a way to positively impact student cognitive and affective learning. …”