Image_1_Cardioprotecive Properties of Known Agents in Rat Ischemia-Reperfusion Model Under Clinically Relevant Conditions: Only the NAD Precursor Nicotinamide Riboside Reduces Infa... by Yang Xiao (146335)

“…., opiates, benzodiazepines, P2Y₁₂ antagonist, propofol) need to be identified in preclinical models.</p><p>Methods: Here, we examined the efficacy of promising cardioprotective compounds [fingolimod (Fingo), empagliflozin (Empa), melatonin (Mela) and nicotinamide riboside (NR)] administered i.v. as bolus before start ischemia. …”

Effects of siRNA on RET/PTC3 Junction Oncogene in Papillary Thyroid Carcinoma: From Molecular and Cellular Studies to Preclinical Investigations by Hafiz Muhammad Ali (554920)

“…Our aim is to demonstrate <i>in vitro</i> and <i>in vivo</i> molecular and cellular effects of siRNA on <i>RET/PTC3</i> knockdown for therapeutic application.First, we established a novel cell line stably expressing <i>RET/PTC3</i> junction oncogene, named RP3 which was found tumorigenic in nude mice compared to NIH/3T3 mouse fibroblasts. …”

Data_Sheet_1_Cardioprotecive Properties of Known Agents in Rat Ischemia-Reperfusion Model Under Clinically Relevant Conditions: Only the NAD Precursor Nicotinamide Riboside Reduces... by Yang Xiao (146335)

“…., opiates, benzodiazepines, P2Y₁₂ antagonist, propofol) need to be identified in preclinical models.</p><p>Methods: Here, we examined the efficacy of promising cardioprotective compounds [fingolimod (Fingo), empagliflozin (Empa), melatonin (Mela) and nicotinamide riboside (NR)] administered i.v. as bolus before start ischemia. …”

Insights into the mechanism regulating the differential expression of the P28-OMP outer membrane proteins in obligatory intracellular pathogen <i>Ehrlichia chaffeensis</i> by Nan Duan (4837896)

Presentation 1_Telehealth coaching in older adults, behavior change, and impacts of the COVID-19 pandemic: analyses from The Brain Health Champion Study.pdf by Brittany McFeeley (21104825)

“…Study 1.0 participants indicated a decrease in cognitive activities since the start of COVID-19 restrictions, whereas those in Study 2.0 reported an increase in cognitive activities.…”

Validation of selected phages binding on RMS cells <i>in vivo</i> and <i>in vitro</i>. by Katarina Hajdin (249498)

“…Data are presented as percentage of maximal phage binding obtained in the absence of synthetic peptide. Error bars indicate mean ± SD from three independent experiments. Binding of phage RMS-P3 decreases significantly with increasing concentrations of synthetic peptide RMP-P3 (least-squares regression, N = 18, r² = 0.889, b = −17.5, p<0.0001), but not for control peptide (N = 18, r² = 0.0002, b = 0.055, p = 0.959).…”

Quantification of specific polyadenylated transcripts upon egg aging. by Anna Kosubek (239172)

“…The transcripts are named according to the corresponding gene symbols listed in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0013532#pone.0013532.s004" target="_blank">Table S1</a> and were selected based on their >4-fold decrease in the microarray upon egg aging. …”

Schematic depicting the effects of truncation on consensus sequence position relative to array surface. by Nicholas O. Fischer (94124)

“…Truncations from both termini (5′[1]3′[1], 5′[2]3′[1], and 5′[1]3′[2]) result in a combination of both effects.…”

Clathrin-dependent Endocytosis is required for removal of Robo from the surface. by Rebecca K. Chance (2207449)

“…S2R+ cells treated with CM from cells expressing Slit (B) as opposed to empty vector (A) show a decrease in surface levels of Robo, quantified in (G) as a percent decrease in average pixel intensity value of processes in (B) as compared to (A). …”

Prior entrainment conditions determine the rate of damping in cells expressing KaiC^EE. by Ximing Qin (247294)

“…<p>Cells were in LL at 30°C before and after the following entrainment conditions: (A) one 12 h dark pulse, (B) one 24 h dark pulse, (C) two 12 h dark pulses separated by one 12 h light pulse (i.e., 1.5 cycles of LD12:12), and (D) two 24 h dark pulses separated by one 24 h light pulse (i.e., 1.5 cycles of LD24:24). …”

Unrestrained Rac 1 activation in pRb-expressing osteoblasts mimics pRb loss by perturbing cell adhesion. by Bernadette Sosa-García (237746)

“…<p>Phase contrast photomicrographs at x10 (<b>A</b>) and growth curves (<b>B</b>) showing that pRb-expressing MC3T3 osteoblasts stably expressing RacV12 or dnCdk5 grow in culture to a higher density relative to pRb-expressing MC3T3 osteoblasts transfected with control vector (CV). …”

Post-injury berberine treatment attenuated brain edema, blood-brain barrier (BBB) permeability, matrix metalloproteinase (MMP)-9 enzymatic activity, neutrophil infiltration and ICA... by Chien-Cheng Chen (207053)

“…<p>Berberine (10 mg·kg⁻¹) significantly decreased (<b>A</b>) brain water content and (<b>B</b>) leakage of Evans Blue into the brain and in the ipsilateral hemisphere compared with the vehicle-treated mice. …”

Functional Trait Strategies of Trees in Dry and Wet Tropical Forests Are Similar but Differ in Their Consequences for Succession by Madelon Lohbeck (731258)

“…We evaluated whether multivariate plant strategies changed during succession, by calculating a ‘Community-Weighted Mean’ plant strategy, based on species scores on the first two PCA-axes. …”

GBP1 overexpression promotes formation and release of infectious viral particles. by Daniela Bender (12467944)

“…To better visualize the GBP1 distribution the signal of the red channel was decreased. Scale bar, 10 μm. The additional zoom factor was 3.5. …”

The <em>PNPLA3</em> rs738409 G-Allele Associates with Reduced Fasting Serum Triglyceride and Serum Cholesterol in Danes with Impaired Glucose Regulation by Nikolaj Thure Krarup (154013)

“…In Inter99, we analyzed associations of rs738409 with components of the WHO-defined metabolic syndrome (<em>n</em> = 5,847) and traits related to metabolic disease (<em>n</em> = 5,663). …”

Summary of model behaviour for internal noise amplitude and spectral slope estimation. by Daniel H. Baker (327642)

“…Noise with steeper slopes (ɑ = 1.5–2.0) increased mean dominance duration as a function of noise contrast, while noise with shallower slopes decreased mean dominance duration. …”

Age-dependent ASM at <i>MCHR1</i>. by Stefanie Stepanow (219536)

“…<b>B:</b> ASM in the intermediate group (40–50 years, n = 10; <i>P</i> = 0.053, <i>t</i>-test). The GT allele shows a mean methylation of 20.7±5.1% and the AC allele is 26.5±4.4% methylated. …”

DataSheet_1_Thalamocortical Hyperconnectivity and Amygdala-Cortical Hypoconnectivity in Male Patients With Autism Spectrum Disorder.doc by Tetsuya Iidaka (162492)

“…</p><p>Methods: To overcome this issue, we analyzed multisite neuroimaging data from a large sample (n = 626) of male participants aged between 5 and 29 years (mean age = 13 years). …”

Testing the “Read-across hypothesis” by investigating the effects of ibuprofen on fish. by Alpa Patel (2937030)

“…Results showed that PGEM levels in fish exposed to 370 and 470 µg ibuprofen/L were significantly decreased compared to control fish, when mean plasma ibuprofen concentrations were 1.8 to 5.6-fold below the C_max. …”

DataSheet_1_Thalamocortical Hyperconnectivity and Amygdala-Cortical Hypoconnectivity in Male Patients With Autism Spectrum Disorder.doc by Tetsuya Iidaka (162492)

“…</p><p>Methods: To overcome this issue, we analyzed multisite neuroimaging data from a large sample (n = 626) of male participants aged between 5 and 29 years (mean age = 13 years). …”