Antiviral therapies and viral strain affect COVID-19 severity. by Chrysovalantis Voutouri (612840)

“…<p><u>D</u>iagrams of peak viral load (A) and minimum oxygen saturation (SpO₂) (B) caused by viral infection as a function of viral immune evasion and relative decrease of virus replication rate, K_in, with antiviral drugs. ’Favorable’ outcomes for viral load correspond to low concentrations, while ’unfavorable’ outcomes relate to high concentrations. …”

Time-dependence of the HMGB1-induced suppression of cellular bioenergetics in RAW 264.7 macrophages. by Domokos Gerö (422086)

“…<b>A:</b> Time-dependent decrease in basal cellular respiration (Oxygen Consumption Rate, OCR). …”

Data_Sheet_1_Transformation of Plant to Resource Acquisition Under High Nitrogen Addition Will Reduce Green Roof Ecosystem Functioning.docx by Qinze Zhang (12554101)

“…We highlight that there is a trade-off between the survival of green roof species and keeping the ecosystem functioning well in the future N deposition. …”

Neonatal Maternal Deprivation Response and Developmental Changes in Gene Expression Revealed by Hypothalamic Gene Expression Profiling in Mice by Feng Ding (33360)

“…Unlike in adult rodents, expression levels of <em>Nanos2</em> and <em>Pdk4</em> were increased, and those of <em>Pgpep1</em>, <em>Ndp</em>, <em>Brms1l</em>, <em>Mett10d</em>, and <em>Snx1</em> were decreased after neonatal deprivation. In addition, we compared hypothalamic gene expression profiles at postnatal days 5 and 13 and observed significant developmental changes. …”

Lhx1 controls the differential expression of Dab1 in LMC neurons. by Elena Palmesino (179868)

“…<p>(A–N) e12.5 lumbar spinal cord Dab1 protein (A–H) and mRNA (I–N) expression in LMCl (Isl1⁻ Foxp1⁺) is decreased in <i>Lhx1^COND</i> mutants (E–H, L–N) compared to control embryos (A–D, I–K). …”

Working memory impairment, which is not delay-dependent in chronic PCP-treated mice. by Yosefu Arime (470391)

“…<p>(A) Experimental schedules for the discrete paired-trial variable-delay task in T-maze and the drug treatments. …”

1561_pHW_Perth09-HA-G78D-T212I.gb by Valerie Le Sage (10669206)

“…Mutations in the HA head at positions 78 and 212 of A/Perth/16/2009 (H3N2), which were selected after cell culture adaptation, decreased the acid stability of the virus from pH 5.5 (WT) to pH 5.8 (mutant). …”

Lysosomal BK channels facilitate silica-induced inflammation in macrophages by Rebekah L. Kendall (14605289)

Data_Sheet_1_Chronic Δ9-tetrahydrocannabinol impact on plasticity, and differential activation requirement for CB1-dependent long-term depression in ventral tegmental area GABA neu... by Isaac Ostlund (14349531)

“…In young mice, VTA GABA cells exhibit a form of synaptic plasticity known as long-term depression (LTD) that is dependent on cannabinoid 1 (CB1) receptors preceded by metabotropic glutamate receptor 5 (mGluR5) signaling to induce endocannabinoid production. …”

Image_1_Identification of Immune-Related Gene Signature and Prediction of CeRNA Network in Active Ulcerative Colitis.tif by Mengmeng Xu (1696420)

“…RT-PCR revealed that andrographolide (AGP) significantly inhibited the expression of hub genes. Finally, we identified XIST and three miRNAs (miR-9-5p, miR-129-5p, and miR-340-5p) as therapeutic targets.…”

Data_Sheet_1_Identification of Biologically Active Ganoderma lucidum Compounds and Synthesis of Improved Derivatives That Confer Anti-cancer Activities in vitro.docx by Michelle M. Martínez-Montemayor (383853)

“…Three of the seven compounds (ergosterol, 5,6-dehydroergosterol and ergosterol peroxide) exhibited significant in vitro anti-cancer activities, while we report for the first time the structure elucidation of 5,6-dehydroergosterol from Ganoderma lucidum. …”

Overlap of epigenetic signatures and Hi-C contacts. by Ittai E. Eres (7010684)

“…<p>(A) Hi-C loci that do not make contact with promoters are ranked in order of decreasing DC FDR (x-axis). …”

Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis by Lorena Fernandez-Mosquera (5077820)

“…</p> <p><b>Abbreviation</b>: ΔΨ_m: mitochondrial transmembrane potential; AMP: adenosine monophosphate; AMPK: AMP-activated protein kinase; ATG5: autophagy related 5; ATP: adenosine triphosphate; ATP6V0A1: ATPase, H+ transporting, lysosomal, V0 subbunit A1; ATP6V1A: ATPase, H+ transporting, lysosomal, V0 subbunit A; BSA: bovine serum albumin; CCCP: carbonyl cyanide-m-chlorophenylhydrazone; CREB1: cAMP response element binding protein 1; CTSD: cathepsin D; CTSF: cathepsin F; DMEM: Dulbecco’s modified Eagle’s medium; DMSO: dimethyl sulfoxide; EBSS: Earl’s balanced salt solution; ER: endoplasmic reticulum; FBS: fetal bovine serum; FCCP: carbonyl cyanide-p-trifluoromethoxyphenolhydrazone; GFP: green fluorescent protein; GPN: glycyl-L-phenylalanine 2-naphthylamide; LAMP1: lysosomal associated membrane protein 1; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; MCOLN1/TRPML1: mucolipin 1; MEF: mouse embryonic fibroblast; MITF: melanocyte inducing transcription factor; ML1N*2-GFP: probe used to detect PtdIns(3,5)P₂ based on the transmembrane domain of MCOLN1; MTORC1: mechanistic target of rapamycin kinase complex 1; NDUFS4: NADH:ubiquinone oxidoreductase subunit S4; OCR: oxygen consumption rate; PBS: phosphate-buffered saline; pcDNA: plasmid cytomegalovirus promoter DNA; PCR: polymerase chain reaction; PtdIns3P: phosphatidylinositol-3-phosphate; PtdIns(3,5)P₂: phosphatidylinositol-3,5-bisphosphate; PIKFYVE: phosphoinositide kinase, FYVE-type zinc finger containing; P/S: penicillin-streptomycin; PVDF: polyvinylidene fluoride; qPCR: quantitative real time polymerase chain reaction; RFP: red fluorescent protein; RNA: ribonucleic acid; SDS-PAGE: sodium dodecyl sulfate polyacrylamide gel electrophoresis; shRNA: short hairpin RNA; siRNA: small interfering RNA; TFEB: transcription factor EB; TFE3: transcription factor binding to IGHM enhancer 3; TMRM: tetramethylrhodamine, methyl ester, perchlorate; ULK1: unc-51 like autophagy activating kinase 1; ULK2: unc-51 like autophagy activating kinase 2; UQCRC1: ubiquinol-cytochrome c reductase core protein 1; v-ATPase: vacuolar-type H+-translocating ATPase; WT: wild-type</p>…”

NDPK stimulates growth in liquid medium. by Sarah J. Annesley (202479)

“…<p>The generation time for wild type and NDPK transformants was measured in three independent experiments and the mean for each transformant was plotted against the NDPK expression index (defined as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026024#pone-0026024-g005" target="_blank">Fig. 5</a>). …”

Loss of Circulating CD4 T Cells with B Cell Helper Function during Chronic HIV Infection by Kristin L. Boswell (517523)

“…In co-culture experiments we confirmed CXCR5+ cells from HIV-uninfected donors provide help to B cells and more specifically, we identified a CCR7^highCXCR5^highCCR6^highPD-1^high CD4 T cell population that secretes IL-21 and enhances isotype-switched immunoglobulin production. …”

Steady-state and dynamic FRET analysis of TRPV1-Caveolin-1 interaction. by Barbara Storti (193389)

“…(a) Donor (Caveolin-EGFP) emission image; (b) acceptor (TRPV1-RFP) emission image; (c) SE-FRET intensity image (scale bar: 5 μm); (d) zoom of a cellular region where FRET-<i>i</i>MSD analysis is later performed; (e) donor-normalized apparent FRET efficiency <i>E</i><sub><i>D</i>.…”

Image_2_Menthol Flavor in E-Cigarette Vapor Modulates Social Behavior Correlated With Central and Peripheral Changes of Immunometabolic Signalings.TIFF by Zhibin Xu (288627)

“…Multiple sera cytokines including C5, TIMP-1, and CXCL13 were decreased accordingly as per their peripheral immunometabolic responses to menthol flavor in the nicotine vapor. …”

Image_1_Menthol Flavor in E-Cigarette Vapor Modulates Social Behavior Correlated With Central and Peripheral Changes of Immunometabolic Signalings.TIFF by Zhibin Xu (288627)

“…Multiple sera cytokines including C5, TIMP-1, and CXCL13 were decreased accordingly as per their peripheral immunometabolic responses to menthol flavor in the nicotine vapor. …”

The Involvement of Oxytocin in the Subthalamic Nucleus on Relapse to Methamphetamine-Seeking Behaviour by Sarah Jane Baracz (784523)

“…We found that local administration of the highest oxytocin dose (3.6 pmol) into the STh decreased METH-induced reinstatement and desGly-NH2,d(CH2)5[D-Tyr2,Thr4]OVT had a non-specific effect on lever press activity. …”

Image_2_Menthol Flavor in E-Cigarette Vapor Modulates Social Behavior Correlated With Central and Peripheral Changes of Immunometabolic Signalings.TIFF by Zhibin Xu (288627)

“…Multiple sera cytokines including C5, TIMP-1, and CXCL13 were decreased accordingly as per their peripheral immunometabolic responses to menthol flavor in the nicotine vapor. …”