Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Minocycline preserves neuronal integrity and decreases astrogliosis. by Eva-Maria Ratai (353640)

“…<b><i>Horizontal bars within boxes represent mean values; height of each box corresponds to a factor of 1.5 times standard deviation. * indicates a significant difference (p≤0.05) between groups.…”

Chronic RAS blockade decreases oxidative stress. by Lai Ming Yung (353970)

VAMP2 decreases 5-HT uptake and SERT cell surface expression in HEK-293 MSR cells by reducing the delivery rate of the transporter to the plasma membrane. by Heidi Kaastrup Müller (570207)

Mean <i>μ</i>_<i>i</i> and standard deviation <i>σ</i>_<i>i</i> of <i>i</i> = [0%, 1%, 2.5%, 5%] concentration datasets. by Ishriak Ahmed (14265562)

Plume encounters are preceded by increased amplitude of head-pitch motion in the active search (5–14 Hz) band, and immediately followed by decreased head-pitch motion. by Mohammad F. Tariq (10727478)

Hsp90 depletion decreases stress resistance. by Michelle D. Leach (108675)

The characterization and the decreased toxicity of liposomal SANT75. by Yike Yuan (396954)

Calpeptin treatment decreases cell density and proliferation. by Daniela M. Santos (211055)

Increased oxidative stress, viral load and decreased survivability of N2a following RIG-I ablation. by Arshed Nazmi (215284)

“…<p>Flow cytometric analysis carried out from cells of all treatment groups to detect intracellular JEV antigen showed significant increase post RIG-I ablation when compared to only JEV-infected or JEV+ScMO groups. The mean fluorescence intensities obtained from each group are depicted in the figure. (1-Unstained, 2-Mock-infected; 3-JEV-infected, 4-JEV+Sc-MO, 5-JEV+rMO) (A). …”

Increase of mitochondrial dysfunction and glycolysis by decreased NEFH. by Myoung Sook Kim (91321)

Regenerating axons are increased by ATRA and decreased by clodronate. by Valeria De La Rosa-Reyes (6658613)

Decrease of receptor detectibility following CRAD replication in a small fraction of cells. by Johan Rebetz (255622)

Effect of MA-5 on mitochondrial respiration. by Yoshitsugu Oikawa (9721356)

Magnetic field setups in zero field (a) and vertically alternating field (b). by Xuegang Mao (599968)

Subjects:

NSAIDs decrease the viability of ovarian cancer cells in a dose-dependent manner. by Blanca L. Valle (406582)

Tranilast decreases OC formation induced by RANKL. by Tien Van Phan (583324)

RGS5 deletion resulted in decreased peripheral insulin sensitivity and suppressed the Akt/GSK3β signaling pathway in mice fed an HF for 24 weeks. by Wei Deng (17330)

Phosphorus application reduces aluminum toxicity in two <i>Eucalyptus</i> clones by increasing its accumulation in roots and decreasing its content in leaves - Fig 5 by Weichao Teng (4760163)