A Reappraisal of the Mechanism by Which Plant Sterols Promote Neutral Sterol Loss in Mice by Gemma Brufau (215229)

“…PS feeding resulted in a dose-dependent decrease of fractional cholesterol absorption (∼2–7-fold reduction) in wild-type mice and ∼80% reduction in Abcg5^-/- mice. …”

Sildenafil inhibits endothelin-induced vasoconstriction but not cellular proliferation in smooth muscle cells. a. by Yoshifumi Kawanabe (308848)

“…</b> To examine the roles of PDE5 in smooth muscle cells, we applied sildenafil on basilar arteries. …”

Effects of mismatched crRNAs on Cas12a-mediated phage defense. by Michael A. Schelling (15295682)

“…<p>(A) Schematic of crRNA expression and processing by FnCas12a and crRNA phage target locations. crRNA mismatches were introduced by mutating individual nucleotides in the spacer sequence. …”

Optimal Dose and Method of Administration of Intravenous Insulin in the Management of Emergency Hyperkalemia: A Systematic Review by Ziv Harel (2696983)

“…</p><p>Results</p><p>We identified eleven studies. In seven studies, 10 units of regular insulin was administered (bolus in five studies, infusion in two studies), in one study 12 units of regular insulin was infused over 30 minutes, and in three studies 20 units of regular insulin was infused over 60 minutes. …”

T cell receptor excision circles as a tool for evaluating thymic function in young children by A. Levy (3995762)

“…In order to evaluate thymic function in the first years of life, we propose measuring TRECs as a valuable tool. One hundred and three blood samples from children and adolescents between 3 months and 20 years of age were analyzed. …”

Human Engineered Heart Tissue as a Versatile Tool in Basic Research and Preclinical Toxicology by Sebastian Schaaf (200540)

“…However, high content experimental platforms are lacking that allow the function of hESC-derived cardiomyocytes to be studied under relatively physiological and standardized conditions. Here we describe a simple and robust protocol for the generation of fibrin-based human engineered heart tissue (hEHT) in a 24-well format using an unselected population of differentiated human embryonic stem cells containing 30–40% α-actinin-positive cardiac myocytes. …”

Model response characteristics produced as a result of adjusting AMPA and NMDA conductance levels. by Cal F. Rabang (191595)

“…<p>Y-axis values correspond to AMPA conductance (0 – 20 nS), X-axis values correspond to ratio of NMDA to AMPA conductance (0, .5, 1, 1.5, 2, 2.5, 3). Values of AMPA conductance and NMDA:AMPA ratio chosen for Large and Small IC inputs are identified by a white L and S on the 100 ms color plots, respectively. …”

Lovastatin treatment results in actin disorganization and inhibits VEGF induced rhoA activation. by Tong T. Zhao (361937)

“…<p>A, Actin cytoskeletal organization was visualized using rhodamine-conjugated phalloidin following 24 hr 0.5, 2 and 5 µM lovastatin treatments of HUVEC. …”

Data_Sheet_3_The chemical neighborhood of cells in a diffusion-limited system.pdf by Juliana Gesztesi (15308869)

“…However, we saw a synergistic effect with multiple cells near each other: multiple cells in close proximity decreased the surrounding concentration by almost 95% from the initial substrate concentration. …”

Data_Sheet_2_The chemical neighborhood of cells in a diffusion-limited system.xlsx by Juliana Gesztesi (15308869)

“…However, we saw a synergistic effect with multiple cells near each other: multiple cells in close proximity decreased the surrounding concentration by almost 95% from the initial substrate concentration. …”

Data_Sheet_1_The chemical neighborhood of cells in a diffusion-limited system.docx by Juliana Gesztesi (15308869)

“…However, we saw a synergistic effect with multiple cells near each other: multiple cells in close proximity decreased the surrounding concentration by almost 95% from the initial substrate concentration. …”

Anti-MUC1* antibodies are a novel surface coating that enables stem cell attachment and growth. by Benoit J. Smagghe (45223)

“…Anti-MUC1* antibody, but not the control antibody, enabled stem cell attachment and growth. BGO1V/hOG hES cells were cultured for 20 passages in NM23-H1-MM without a decrease in pluripotency or change in karyotype (data not shown). …”

Techno-Economic Assessment of Renewably Powered Electrocatalytic Nitrate Reduction for a Sustainable Nitrogen Cycle by Biyu Kang (20231622)

Ligand-dependent stability of a 240 kDa protein can be probed by FASTpp. by David Minde (470117)

“…A gradual decrease in the band intensity at higher temperatures indicates unfolding. …”

Incidence and survival of laryngeal cancer in Denmark: a nation-wide study from 1980 to 2014 by Arvin Nahavandipour (6415004)

“…Considering the anatomic location, we found that glottic cancer had a significantly better survival at five years compared to the other locations. …”

Supplementary Material for: Phacoemulsification with and without iStent: a systematic review and meta-analysis of comparative studies by Shokry A. Shokry (754648)

DataSheet1_Understanding the impact of radiotherapy fractionation on overall survival in a large head and neck squamous cell carcinoma dataset: a comprehensive approach combining m... by Igor Shuryak (337356)

“…Our previous analyses of radiotherapy-only HNSCC clinical trials data using mechanistically-motivated models of tumor repopulation and killing by radiotherapy predicted that hyperfractionation with twice-daily fractions, or hypofractionation involving increased doses/fraction and reduced treatment durations, both improve tumor control and reduce late normal tissue toxicity, compared with standard protocols using 35×2 Gy. Here we further investigated the validity of these conclusions by analyzing a large modern dataset on 3,346 HNSCC radiotherapy patients from the University Health Network in Toronto, Canada, where 42.5% of patients were also treated with chemotherapy.…”

Pancreatic Differentiation of Stem Cells Reveals Pathogenesis of a Syndrome of Ketosis-Prone Diabetes by Diane Yang (11198946)

“…Genetic analysis of an adult patient with an unusual course of Ketosis-Prone Diabetes (KPD) and lacking islet autoantibodies demonstrated a nucleotide variant in the<i> </i>5’-UTR of <i>PDX1</i>, a beta-cell development gene. …”

A COX inhibitor does not prevent the development of tactile allodynia after nerve injury. by Shigeo Hasegawa (249454)

“…The COX-1 inhibitor SC-560 (20 nmol/10 µl) administered through a catheter whose tip was positioned near the L5 DRG once daily for 14 days did not suppress the development of nerve injury-induced a decrease in the paw withdrawal threshold of tactile stimulation using von Frey filaments. …”

A Bibliometric Analysis of Articles Published in Brazilian Dental Journal over 30 years by Rafael Ratto de Moraes (5790326)

“…Most articles had origin in Brazil (90%), followed by USA (4.6%) and UK (1.5%). Aside from BDJ, Journal of Endodontics (3.5%) and International Endodontic Journal (2.2%) were journals that most often cited BDJ. …”