Discovery of an Orally Active PDE1 Inhibitor for Disease-Modifying Treatment of Postmenopausal Osteoporosis via Dual Anabolic-Antiresorptive Mechanisms by Farman M. Abbasi (22318766)

Subjects:

Discovery of an Orally Active PDE1 Inhibitor for Disease-Modifying Treatment of Postmenopausal Osteoporosis via Dual Anabolic-Antiresorptive Mechanisms by Farman M. Abbasi (22318766)

Subjects:

Hydrogen-Bonding Trends in a Bithiophene with 3- and/or 4‑Pyridyl Substituents by Alison M. Costello (16456762)

“…We found that with the 5-(3-pyridyl)-5′-(4-pyridyl)-isomer, the 4-pyridyl ring interacted with electrophiles and protons more strongly. …”

Hydrogen-Bonding Trends in a Bithiophene with 3- and/or 4‑Pyridyl Substituents by Alison M. Costello (16456762)

“…We found that with the 5-(3-pyridyl)-5′-(4-pyridyl)-isomer, the 4-pyridyl ring interacted with electrophiles and protons more strongly. …”

GAS5 levels are decreased in bladder cancer. by Zhihong Liu (112690)

Scara5 expression decreased during retinopathy. by Luísa Mendes-Jorge (635136)

“…C: The immunolabeling of paraffin-embedded retinal sections with anti-Scara5 antibody confirmed that Scara5 expression decreased throughout the parenchyma. …”

Resistance to Pap-A correlates with decreases in PS. by Chelsi D. Cassilly (2793433)

FGF8b decreased GnRH mRNA in GT1-7 cells. by Natasha N. Mott (341221)

Claudin V is decreased following infection with Mtb. by Amanda S. Latham (12093638)

“…<p>Immunofluorescent staining of guinea pig brain tissue for DAPI (blue) and claudin V (cyan) in vessels was performed. Representative images of the frontal cortex (A–D), cerebral nuclei (F–I), brain stem (K–N), thalamus (P–S), and hippocampus (U–X) 15 days post-infection are shown. …”

Diannexin attenuates release of MPs after hepatic IRI and decreases their pro-inflammatory and deleterious potential. by Narci C. Teoh (629957)

Clinical and genetic characteristics of 5 patients harboring mutations in the <i>NR5A1</i> gene. by Jana Malikova (615672)

Subjects:

Decreasing Fires in Mediterranean Europe - Fig 5 by Marco Turco (3178641)

SKO mice demonstrate increased cholesterol efflux in whole skin, and decreased cholesterol levels in plasma. by Sabrina N. Dumas (5474456)

Decreased growth rate and lack of tunicamycin sensitivity of <i>ΔgbcO</i> mutant. by Élise Caliot (158922)

Transfection of human primary adipocytes in suspension with siRNA is associated with decreased expression of targeted proteins. by Gail Kilroy (370499)

PLD1 inhibition decreases the c-Myc-dependent dNTP biosynthetic transcriptional program. by Harry E. Taylor (596259)

The role of AGEs in high glucose-induced voltage-gated K⁺ (K_v) channels dysfunction in vascular smooth muscle cells (VSMCs). by Wen Su (332346)

“…B: I-V relationships of K_v current density in VSMCs. …”

WT1 (+KTS) decreases basal and GnRH-stimulated LHβ promoter activity. by Debalina Bagchi (686046)

Gene ontology biological processes overrepresented among genes exhibiting decreased expression in human psoriasis. by William R. Swindell (175427)

“…<p>A total of 3540 transcripts were identified as significantly decreased in psoriatic plaques obtained from human patients relative to normal skin obtained from control subjects (FDR-adjusted P<0.05 and log₂-transformed fold-change less than -0.50). …”

Table 1_Increased frequencies of human Th-17 CD4+ T-cells and decreased T-regulatory cells in patients with early and advanced metabolic dysfunction-associated steatotic liver dise... by Elżbieta Supruniuk (16736637)