Biomarkers and overall survival in patients with advanced hepatocellular carcinoma treated with TGF-βRI inhibitor galunisertib by Gianluigi Giannelli (94866)

“…In AFP responders (21% of patients in Part A with decrease of >20% from baseline) versus non-responders, median OS was 21.5 months versus 6.8 months (p = 0.0015). …”

Table 3_Quantitative N-glycoproteomic analysis reveals glycosylation signatures of plasma immunoglobulin G in systemic sclerosis.xlsx by Lu Cheng (141959)

“…The correlation of specific intact N-glycopeptides with the clinical features of SSc patients was analyzed. The results revealed a notable increase in the levels of 6 intact N-glycopeptides (IgG2-N3H3F1, IgG2-N3H4F1, IgG2-N4H4F1, IgG2-N4H5F1, IgG2-N5H4F1, and IgG2-N5H5F1) and a decrease in the levels of another set of 6 intact N-glycopeptides (IgG1-N4H3F1, IgG2-N3H6F1A1, IgG2-N4H4F1A1, IgG2-N5H3F1, IgG3-N4H3F1, and IgG3-N4H4F1). …”

Rictor down-regulation sensitizes chemoresistant OVCA cells to CDDP-induced apoptosis by facilitating Akt proteasomal degradation. by Akechai Im-aram (5656237)

“…Rictor knock-down significantly enhanced CDDP-induced apoptosis in chemoresistant OVCA cells (P<0.01 and P<0.001, respectively) and this effect was rescued by epoxomycin (P<0.05 and p<0.001, respectively) Total-Akt was significantly decreased during rictor silencing with CDDP treatment (P<0.05) and a massive increase in the ratio between phospho-Akt (Ser473) and total-Akt was also observed, which significantly decreased when epoxomycin was added (P<0.001 and P<0.05, respectively) Results are presented as mean ± SEM of three independent experiments. …”

Bariatric surgery and the coronary artery calcium score. by Daniel da Costa Lins (6879683)

“…The mean CACS increased significantly at the late postoperative period, going from 8.5 to 33.1. …”

Chlorogenic Acid Prevents Osteoporosis by Shp2/PI3K/Akt Pathway in Ovariectomized Rats by Rong Ping Zhou (3607778)

“…Sixty female Sprague-Dawley rats were divided randomly among a sham-operated group and five ovariectomy (OVX) plus treatment subgroups: saline vehicle, 17α-ethinylestradiol (E2), or CGA at 9, 27, or 45 mg/kg/d. …”

Table_1_Characterization of the Teleneurology Patients at the Hospital Las Higueras de Talcahuano—Chile.XLSX by Freddy Constanzo (6882176)

“…The patients were referred to a neurologist in the teleneurology program from different primary healthcare centers (93.5%) and tertiary healthcare centers (6.5%). …”

Data_Sheet_1_Cold Acclimation and Deacclimation of Two Garden Rose Cultivars Under Controlled Daylength and Temperature.docx by Lin Ouyang (8466462)

“…Increasing the temperature after a cold period resulted in fast deacclimation as found by the downregulation of RhDHN5 and RhBAM3, the decrease of raffinose and stachyose. …”

Endoglin Requirement for BMP9 Signaling in Endothelial Cells Reveals New Mechanism of Action for Selective Anti-Endoglin Antibodies by Olivier Nolan-Stevaux (106964)

“…<em>ENG</em> and <em>ACVRL1</em> are both required for angiogenesis and mutations in either gene are associated with Hereditary Hemorrhagic Telangectasia, a rare genetic vascular disorder. ENG and ALK1 function in the same genetic pathway but the relative contribution of TGFβ and BMP9 to SMAD1/5/8 activation and the requirement of ENG as a co-mediator of SMAD phosphorylation in endothelial cells remain debated. …”

Greater accumulation of exopolymeric matrix on Asc10⁺<i>E. faecalis</i> biofilms, in comparison to Asc10⁻ biofilms. by Olivia N. Chuang-Smith (160012)

“…<p>Scanning electron micrographs of <i>E. faecalis</i> Asc10⁺ OG1SSp (pCF10) incubated 0.5 h (<b>A</b>) and 2 h (<b>B</b>) showing typical comparatively smooth appearance of the bacterial surface at early incubation times (<b>A</b>) compared to the fibrillar strands that became more evident over time (<b>B</b>). …”

Supplementary Material for: Influence of Antipsychotic Agents on Heart Rate Variability in Male WKY Rats: Implications for Cardiovascular Safety by Wang Y.-C. (4132195)

“…<b><i>Conclusion:</i></b> Taking this evidence as a whole, we conclude that haloperidol has a better level of cardiovascular safety than either risperidone or clozapine. …”

Robust Superhydrophobic Surface Based on Multiple Hybrid Coatings for Application in Corrosion Protection by Yaya Zhou (6278546)

“…It does not only show a large water contact angle (ca. 174.5°) but also a slight decrease (ca. 6.4%) of water contact angle after 100 mechanical abrasion cycles. …”

Antioxidants Abrogate Alpha-Tocopherylquinone-Mediated Down-Regulation of the Androgen Receptor in Androgen-Responsive Prostate Cancer Cells - Fig 2 by Alexandra M. Fajardo (3176451)

“…(D) Determination of LNCaP growth foci following treatment with either 10 μM AT or 10 μM TQ for 5 d. (E) Viability analysis in DU145, LAPC4 and LNCaP cells at 5, 10, and 25 μM TQ for 48 h with no decrease in cell viability. …”

Data_Sheet_1_Characterization of the Teleneurology Patients at the Hospital Las Higueras de Talcahuano—Chile.PDF by Freddy Constanzo (6882176)

“…The patients were referred to a neurologist in the teleneurology program from different primary healthcare centers (93.5%) and tertiary healthcare centers (6.5%). …”

Misregulation of Foxe3 expression in c-myc-deficient lens. by Gabriel R. Cavalheiro (439798)

“…<p><b>(A–B)</b> Representative confocal pictures of an immunofluorescence for Foxe3 performed in control (<i>c-myc^Ctrl</i>) (<b>A</b>) and c-myc-deficient (<i>c-myc^Le-Cre</i>) (<b>B</b>) lens sections at E13.5 followed by sytox green nuclear counterstaining. …”

Table 1_Potential shared gene signatures and molecular mechanisms between recurrent pregnancy loss and ovarian cancer.docx by Yan Wang (15435)

“…Then stepAIC analysis was performed to simplify the model and decrease the number of genes, which yielded a final set of 5 prognostic genes with coefficients to construct a prognostic risk scoring system. …”

Ocular delivery of moxifloxacin-loaded liposomes by Kaline Sandrelli Amorim Ferreira (5835818)

“…The results of an in vivo release study of liposomes containing moxifloxacin, showed that the maximum moxifloxacin concentration was achieved within the first 2 h after administration (5.27 ± 1.09 mg/mL) and was followed by a decrease in intracameral concentration (0.35 ± 0.05 mg/mL) until the 24 h mark. …”

Bladder hyper-permeability is present in the URO-MCP-1 IC mouse model. by Nataliya Smith (40735)

“…(D) Trans-epithelial electrical resistance (TEER) (Ω.cm²) of mouse bladders (<i>ex vivo</i>) that were either treated with saline (open squares; n = 5) or LPS (closed triangles; n = 5). There was a significant decrease in TEER in LPS-treated URO-MCP-1 mice, compared to saline-treated mice (**p<0.01). …”

The Diversity and Abundance of Insects in Danby Woods Based on the Moisture Levels of the Soil by Keerthana Ledchumykanthan (794790)

“…We planned on taking 60 quadrats, for a total of 120, per day and looking at each quadrat for 5 minutes. …”

Dosimetry in CBCT with Different Protocols: Emphasis on Small FOVs Including Exams for TMJ by Helena Aguiar Ribeiro Nascimento (4654531)

“…CBCT scans were obtained on OP300 Maxio unit varying scanning mode (standard, high and endo) as well as size (5x5, 6x8 and 8x15 cm) and positioning of FOV. With a small FOV, different areas were scanned (maxilla or mandible, anterior or posterior and TMJ). …”

Data_Sheet_1_Contribution of Fluorescence Techniques in Determining the Efficiency of the Non-thermal Plasma Treatment.docx by Gaëlle Carré (4183618)

“…FC and CLSM highlight that O₂ and Ar NTP treatments were the most attractive processes. Indeed, a 5 min of Ar NTP generated a high destruction of the structure of bacteria and a 120 min of O₂ NTP treatment led to the higher decrease of the total damaged bacteria population. …”